List of works - Haopeng Sun

A Mild and Direct C(sp3)-S Cross-Coupling of Oxindoles with Thiols: Synthesis of Unsymmetrical 3-Thiooxindoles

scientific article published on 16 October 2019

Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors

scientific article published on 31 May 2019

Anti-angiogenic and anticancer effects of baicalein derivatives based on transgenic zebrafish model

scientific article published on 23 July 2018

Bioactivity-based analysis and chemical characterization of hypoglycemic and antioxidant components from Artemisia argyi

scientific article published on 12 September 2019

CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors

scientific article published on 21 December 2018

Characterization, quantitation, similarity evaluation and combination with Na+,K+-ATPase of cardiac glycosides from Streblus asper

scientific article published on 19 March 2019

Combination of pharmacophore model development and binding mode analyses: identification of ligand features essential for IκB kinase-beta (IKKβ) inhibitors and virtual screening based on it

scientific article published on June 25, 2011

Convenient Method of Synthesizing Aryloxyalkyl Esters from Phenolic Esters Using Halogenated Alcohols.

scientific article published on 13 July 2018

Current Development of ROS-Modulating Agents as Novel Antitumor Therapy

scientific article published on 16 February 2016

Degradation of proteins by PROTACs and other strategies

scientific article published on 13 August 2019

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors

scientific article published on 31 August 2013

Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells

scientific article published on 02 December 2019

Design of Multi-Target Agents for the treatment of Alzheimer's Disease Based on Tacrine

scientific article

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy

scientific article published on 6 December 2017

Design, synthesis and evaluation of tacrine–flurbiprofen–nitrate trihybrids as novel anti-Alzheimer’s disease agents ⬇️

scientific article published on March 13, 2013

Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors

scientific article published on 23 September 2019

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease

scientific article published on 01 December 2020

Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening

scientific article published on 17 July 2015

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis

scientific article

Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening

scientific article published on 19 September 2019

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

scientific article published on 13 September 2018

Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors

scientific article published on 7 October 2013

Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation

scientific article published on 10 March 2022

Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation

scientific article published on 21 December 2018

Gamma secretase inhibitors: a patent review (2013 - 2015).

scientific article published on 28 March 2017

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening

scientific article published on 21 March 2014

Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening ⬇️

scientific article published on April 2, 2013

Influence of c-Src on hypoxic resistance to paclitaxel in human ovarian cancer cells and reversal of FV-429.

scientific article published on 11 January 2018

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation

scientific article

Insights into targeting NEMO for pharmacological regulation

scientific article published on January 2014

Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.

scientific article published on 13 February 2018

Key Role of Nuclear Factor-κB in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2 ⬇️

scientific article published on June 27, 2012

LYG-202 Augments Tumor Necrosis Factor-α-Induced Apoptosis via Attenuating Casein Kinase 2-Dependent Nuclear Factor-κB Pathway in HepG2 Cells ⬇️

scientific article published on August 21, 2012

NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity ⬇️

scientific article published on April 10, 2013

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

scientific article published on 19 October 2018

Pharmacophore‐Based Drug Design and Biological Evaluation of Novel ABCB1 Inhibitors ⬇️

scientific article published on December 26, 2012

Predicting the potency of hERG K+ channel inhibition by combining 3D-QSAR pharmacophore and 2D-QSAR models ⬇️

scientific article published on June 10, 2011

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms

scientific article published on 28 May 2019

Recent advances in the structure-based and ligand-based design of IKKβ inhibitors as anti-inflammation and anti-cancer agents

scientific article

Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease

scientific article

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry

scientific article published on 31 October 2020

Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation

scientific article published on 19 April 2019

Small molecule modulators targeting protein kinase CK1 and CK2

scientific article published on 01 August 2019

Structure-Based Pharmacophore Modeling from Multicomplex: a Comprehensive Pharmacophore Generation of Protein Kinase CK2 and Virtual Screening Based on it for Novel Inhibitors

scientific article published on 25 May 2011

Studies on Chemical Structure Modification and StructureActivity Relationship of Derivatives of Gambogic Acid at C(39) ⬇️

scientific article published on August 1, 2012

Studies on Chemical‐Structure Modification and StructureActivity Relationship of Gambogic Acid Derivatives at Carbon(34) ⬇️

scientific article published on October 1, 2012

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.

scientific article published in December 2018

Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease

scientific article published in December 2018

Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors ⬇️

scientific article published on April 27, 2012

The Development of Pharmacophore Modeling: Generation and Recent Applications in Drug Discovery

scientific article published on 01 January 2018

List of works by Haopeng Sun

A Mild and Direct C(sp3)-S Cross-Coupling of Oxindoles with Thiols: Synthesis of Unsymmetrical 3-Thiooxindoles

Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors

Anti-angiogenic and anticancer effects of baicalein derivatives based on transgenic zebrafish model

Bioactivity-based analysis and chemical characterization of hypoglycemic and antioxidant components from Artemisia argyi

CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors

Characterization, quantitation, similarity evaluation and combination with Na+,K+-ATPase of cardiac glycosides from Streblus asper

Combination of pharmacophore model development and binding mode analyses: identification of ligand features essential for IκB kinase-beta (IKKβ) inhibitors and virtual screening based on it

Convenient Method of Synthesizing Aryloxyalkyl Esters from Phenolic Esters Using Halogenated Alcohols.

Current Development of ROS-Modulating Agents as Novel Antitumor Therapy

Degradation of proteins by PROTACs and other strategies

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors

Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells

Design of Multi-Target Agents for the treatment of Alzheimer's Disease Based on Tacrine

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy

Design, synthesis and evaluation of tacrine–flurbiprofen–nitrate trihybrids as novel anti-Alzheimer’s disease agents ⬇️

Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease

Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis

Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors

Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation

Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation

Gamma secretase inhibitors: a patent review (2013 - 2015).

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening

Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening ⬇️

Influence of c-Src on hypoxic resistance to paclitaxel in human ovarian cancer cells and reversal of FV-429.

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation

Insights into targeting NEMO for pharmacological regulation

Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.

Key Role of Nuclear Factor-κB in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2 ⬇️

LYG-202 Augments Tumor Necrosis Factor-α-Induced Apoptosis via Attenuating Casein Kinase 2-Dependent Nuclear Factor-κB Pathway in HepG2 Cells ⬇️

NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity ⬇️

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

Pharmacophore‐Based Drug Design and Biological Evaluation of Novel ABCB1 Inhibitors ⬇️

Predicting the potency of hERG K+ channel inhibition by combining 3D-QSAR pharmacophore and 2D-QSAR models ⬇️

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms

Recent advances in the structure-based and ligand-based design of IKKβ inhibitors as anti-inflammation and anti-cancer agents

Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry

Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation

Small molecule modulators targeting protein kinase CK1 and CK2

Structure-Based Pharmacophore Modeling from Multicomplex: a Comprehensive Pharmacophore Generation of Protein Kinase CK2 and Virtual Screening Based on it for Novel Inhibitors

Studies on Chemical Structure Modification and StructureActivity Relationship of Derivatives of Gambogic Acid at C(39) ⬇️

Studies on Chemical‐Structure Modification and StructureActivity Relationship of Gambogic Acid Derivatives at Carbon(34) ⬇️

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.

Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease

Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors ⬇️

The Development of Pharmacophore Modeling: Generation and Recent Applications in Drug Discovery