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List of works by Sylvia van Drunen Littel-van den Hurk

A UL47 gene deletion mutant of bovine herpesvirus type 1 exhibits impaired growth in cell culture and lack of virulence in cattle

scientific article published on January 2010

A distinct role of CD4+ Th17- and Th17-stimulated CD8+ CTL in the pathogenesis of type 1 diabetes and experimental autoimmune encephalomyelitis

scientific article published on 15 June 2011

A novel combination adjuvant platform for human and animal vaccines.

scientific article published on 06 June 2017

A novel triple adjuvant formulation promotes strong, Th1-biased immune responses and significant antigen retention at the site of injection

scientific article published on 16 October 2010

A single DNA immunization in combination with electroporation prolongs the primary immune response and maintains immune memory for six months

scientific article

A single HBsAg DNA vaccination in combination with electroporation elicits long-term antibody responses in sheep

scientific article published on 14 October 2006

A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain

scientific article published on 30 January 2013

A single intranasal immunization with a subunit vaccine formulation induces higher mucosal IgA production than live respiratory syncytial virus

scientific article published on 6 October 2016

A subunit gIV vaccine, produced by transfected mammalian cells in culture, induces mucosal immunity against bovine herpesvirus-1 in cattle

scientific article published on November 1994

Animal models for neonatal diseases in humans

scientific article published on 10 December 2012

Antigenic and immunogenic characteristics of bovine herpesvirus type-1 glycoproteins GVP 3/9 and GVP 6/11a/16, purified by immunoadsorbent chromatography

scientific article

Antigenic and molecular characterization of a herpesvirus isolated from a North American elk.

scientific article

Antigenic differences between the major glycoproteins of bovine herpesvirus type 1.1 and bovine encephalitis herpesvirus type 1.3 ⬇️

scientific article published on August 1, 1993

Approaches to enhance the efficacy of DNA vaccines

scientific article published on January 2004

Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides

scientific article published on 07 January 2009

Biological activity of immunostimulatory CpG DNA motifs in domestic animals

scientific article

Blunted inflammatory and mucosal IgA responses to pneumonia virus of mice in C57BL/6 neonates are correlated to reduced protective immunity upon re-infection as elderly mice

scientific article published on 19 August 2015

Bovine herpesvirus 1 VP22 enhances the efficacy of a DNA vaccine in cattle

scientific article

Bovine herpesvirus 1 attachment to permissive cells is mediated by its major glycoproteins gI, gIII, and gIV ⬇️

scientific article published on March 1, 1991

Bovine herpesvirus 1-induced apoptotic cell death: role of glycoprotein D

scientific article published on 01 April 1999

Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology

scientific article

Bovine herpesvirus-1 US3 protein kinase: critical residues and involvement in the phosphorylation of VP22.

scientific article

Bovine herpesvirus-1 VP8 interacts with DNA damage binding protein-1 (DDB1) and is monoubiquitinated during infection

scientific article published on 19 April 2012

Bovine herpesvirus-1 vaccines

scientific article

Carrier molecules for use in veterinary vaccines

scientific article published on 07 December 2012

Cell-mediated immune responses induced by BHV-1: rational vaccine design

scientific article published on June 2007

Cellulose-based polyelectrolyte complex nanoparticles for DNA vaccine delivery

scientific article published on 07 July 2014

Characterization of cell-binding properties of bovine herpesvirus 1 glycoproteins B, C, and D: identification of a dual cell-binding function of gB ⬇️

scientific article published on August 1, 1995

Characterization of group II avian adenoviruses with a panel of monoclonal antibodies

scientific article published on October 1988

Characterization of nuclear localization and export signals of the major tegument protein VP8 of bovine herpesvirus-1.

scientific article published in July 2004

Characterization of the nuclear localization and nuclear export signals of bovine herpesvirus 1 VP22.

scientific article published on September 2005

Combination adjuvants: the next generation of adjuvants? ⬇️

scientific article published on January 1, 2011

Compatibility of plasmids encoding bovine viral diarrhea virus type 1 and type 2 E2 in a single DNA vaccine formulation

scientific article

Comprehensive Lipidomic and Metabolomic Analysis for Studying Metabolic Changes in Lung Tissue Induced by a Vaccine against Respiratory Syncytial Virus

scientific article published on 06 July 2020

CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved

scientific article published in October 2001

CpG-containing oligodeoxynucleotides, in combination with conventional adjuvants, enhance the magnitude and change the bias of the immune responses to a herpesvirus glycoprotein.

scientific article published in November 2002

DNA immunization with bovine herpesvirus-1 genes

scientific article published on November 1995

DNA vaccination: a simple concept with challenges regarding implementation

scientific article published on 01 May 2006

Defining a standard and weighted mathematical index for maturation of dendritic cells.

scientific article published on 25 October 2017

Delivery of DNA vaccines using electroporation

scientific article published on January 2006

Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS

scientific article published on 25 November 2010

Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3.

scientific article published in January 2006

Effect of different nuclear localization sequences on the immune responses induced by a MIDGE vector encoding bovine herpesvirus-1 glycoprotein D.

scientific article published on 24 August 2005

Efficacy of an experimental BHV-1 subunit gIV vaccine in beef calves challenged with BHV-1 in aerosol.

scientific article published on January 1996

Electroporation enhances immune responses and protection induced by a bovine viral diarrhea virus DNA vaccine in newborn calves with maternal antibodies ⬇️

scientific article published on July 27, 2010

Electroporation for DNA immunization: clinical application

scientific article published on May 2010

Evaluation of baculovirus-expressed bovine herpesvirus-1 (BHV-1) glycoproteins for detection and analysis of BHV-1-specific antibody responses

scientific article published on April 1998

Expression and cellular distribution of baculovirus-expressed bovine herpesvirus 1 (BHV-1) glycoprotein D (gD) sequences

scientific article published on January 1998

Expression of bovine herpesvirus 1 glycoprotein gIV by recombinant baculovirus and analysis of its immunogenic properties

scientific article published on January 1991

Expression of bovine herpesvirus 1 glycoproteins gI and gIII in transfected murine cells

scientific article published on November 1988

Formulation of the respiratory syncytial virus fusion protein with a polymer-based combination adjuvant promotes transient and local innate immune responses and leads to improved adaptive immunity.

scientific article published on 31 August 2016

Formulation with CpG ODN enhances antibody responses to an equine influenza virus vaccine

scientific article published on 6 September 2006

Formulation with CpG oligodeoxynucleotides increases cellular immunity and protection induced by vaccination of calves with formalin-inactivated bovine respiratory syncytial virus

scientific article published on 7 July 2006

Functional analysis of the transmembrane anchor region of bovine herpesvirus 1 glycoprotein gB.

scientific article published on February 1997

Future considerations for dendritic cell immunotherapy against chronic viral infections

scientific article published on 16 April 2014

Glycoprotein Bb, the N-terminal subunit of bovine herpesvirus 1 gB, can bind to heparan sulfate on the surfaces of Madin-Darby bovine kidney cells.

scientific article published on March 1996

Glycoprotein D homologs in herpes simplex virus type 1, pseudorabies virus, and bovine herpes virus type 1 bind directly to human HveC(nectin-1) with different affinities.

scientific article

Glycoprotein H (gII/gp108) and glycoprotein L form a functional complex which plays a role in penetration, but not in attachment, of bovine herpesvirus 1.

scientific article published on July 1996

Herpesvirus tegument and immediate early proteins are pioneers in the battle between viral infection and nuclear domain 10-related host defense

scientific article published on 2 June 2017

High transfection efficiency, gene expression, and viability of monocyte-derived human dendritic cells after nonviral gene transfer

scientific article published on 12 July 2007

IL-12p40 gene-deficient BALB/c mice exhibit lower weight loss, reduced lung pathology and decreased sensitization to allergen in response to infection with pneumonia virus of mice

scientific article published on 8 July 2016

Identification and transcriptional analysis of a 3'-coterminal gene cluster containing UL1, UL2, UL3, and UL3.5 open reading frames of bovine herpesvirus-1.

scientific article published on October 1995

Identification of a mutant bovine herpesvirus-1 (BHV-1) in post-arrival outbreaks of IBR in feedlot calves and protection with conventional vaccination.

scientific article published on April 2001

Immune responses of mice against recombinant bovine herpesvirus 5 glycoprotein D.

scientific article published on 20 March 2014

Immunity and protection by adoptive transfer of dendritic cells transfected with hepatitis C NS3/4A mRNA.

scientific article published on 5 December 2006

Immunization of livestock with DNA vaccines: current studies and future prospects

scientific article published on March 2001

Immunization with a bovine herpesvirus 1 glycoprotein B DNA vaccine induces cytotoxic T-lymphocyte responses in mice and cattle

scientific article published on 01 April 2005

Immunization with a dicistronic plasmid expressing a truncated form of bovine herpesvirus-1 glycoprotein D and the amino-terminal subunit of glycoprotein B results in reduced gB-specific immune responses

scientific article published on 01 August 2003

Immunization with plasmid DNA encoding a truncated, secreted form of the bovine viral diarrhea virus E2 protein elicits strong humoral and cellular immune responses

scientific article published on 13 July 2005

Immunogenicity of a bovine herpesvirus 1 glycoprotein D DNA vaccine complexed with bovine neutrophil beta-defensin 3

scientific article

Immunogenicity of bovine herpesvirus 1 glycoprotein D in mice: effect of antigen form on the induction of cellular and humoral immune responses

scientific article published on 01 January 1996

Immunology of bovine herpesvirus 1 infection

scientific article

Immunopathology of RSV infection: prospects for developing vaccines without this complication

scientific article published on January 2007

Inclusion of the bovine neutrophil beta-defensin 3 with glycoprotein D of bovine herpesvirus 1 in a DNA vaccine modulates immune responses of mice and cattle

scientific article published on 22 January 2014

Induction of functional interferon alpha and gamma responses during acute infection of cattle with non-cytopathic bovine viral diarrhea virus

scientific article

Induction of immune responses by DNA vaccines in large animals

scientific article

Inhibition of bovine sperm-zona binding by bovine herpesvirus-1.

scientific article published in August 2005

Innate immune protection from pneumonia virus of mice induced by a novel immunomodulator is prolonged by dual treatment and mediated by macrophages

scientific article published on 27 August 2019

Innate immunemodulator containing adjuvant formulated HA based vaccine protects mice from lethal infection of highly pathogenic avian influenza H5N1 virus

scientific article published on 31 January 2020

Interaction of VP8 with mRNAs of bovine herpesvirus-1.

scientific article published on 18 December 2014

Intercellular trafficking of the major tegument protein VP22 of bovine herpesvirus-1 and its application to improve a DNA vaccine

scientific article published on 28 December 2005

Intracellular trafficking of VP22 in bovine herpesvirus-1 infected cells

scientific article published on 18 November 2009

Intranasal immunization of mice with a bovine respiratory syncytial virus vaccine induces superior immunity and protection compared to those by subcutaneous delivery or combinations of intranasal and subcutaneous prime-boost strategies

scientific article

Intranasal immunization of mice with a formalin-inactivated bovine respiratory syncytial virus vaccine co-formulated with CpG oligodeoxynucleotides and polyphosphazenes results in enhanced protection

scientific article published in January 2008

Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice

scientific article

Large animal models for vaccine development and testing.

scientific article published on January 2015

Local innate responses and protective immunity after intradermal immunization with bovine viral diarrhea virus E2 protein formulated with a combination adjuvant in cattle.

scientific article published on 17 May 2017

Lymphocyte proliferative responses to recombinant bovine herpes virus type 1 (BHV-1) glycoprotein gD (gIV) in immune cattle: identification of a T cell epitope

scientific article published in January 1995

Lymphocyte proliferative responses to separated bovine herpesvirus 1 proteins in immune cattle

scientific article

Major tegument protein VP8 of bovine herpesvirus 1 is phosphorylated by viral US3 and cellular CK2 protein kinases

scientific article

Mapping of 10 epitopes on bovine herpesvirus type 1 glycoproteins gl and glll ⬇️

scientific article published on May 1, 1990

Metabolomic and Immunological Profiling of Respiratory Syncytial Virus Infection after Intranasal Immunization with a Subunit Vaccine Candidate

scientific article published on 08 February 2019

Modulation of immune responses to bovine herpesvirus-1 in cattle by immunization with a DNA vaccine encoding glycoprotein D as a fusion protein with bovine CD154.

scientific article published in June 2004

Monocytes are required for optimum in vitro stimulation of bovine peripheral blood mononuclear cells by non-methylated CpG motifs

scientific article published on January 2002

Mucosal immune response in newborn Holstein calves that had maternally derived antibodies and were vaccinated with an intranasal multivalent modified-live virus vaccine

scientific article published on May 2012

Multiple administration with interleukin-2 potentiates antigen-specific responses to subunit vaccination with bovine herpesvirus-1 glycoprotein IV

scientific article published on January 1, 1992

Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8

scientific article published on 18 November 2008

Needle-free delivery of veterinary DNA vaccines

scientific article published on January 2006

Novel viral vaccines for livestock

scientific article published on November 1996

Pathogenesis of respiratory syncytial virus

scientific article published on 23 February 2012

Phosphorylation of Bovine Herpesvirus 1 VP8 Plays a Role in Viral DNA Encapsidation and Is Essential for Its Cytoplasmic Localization and Optimal Virion Incorporation

scientific article published on 17 February 2016

Phylogeny and antigenic relationships of three cervid herpesviruses

scientific article published on 2 August 2005

Polynucleotide vaccines in animals: enhancing and modulating responses ⬇️

scientific article published on June 1, 1997

Polypeptide specificity of the antibody response after primary and recurrent infection with bovine herpesvirus 1.

scientific article published on February 1986

Priming by DNA immunization augments T-cell responses induced by modified live bovine herpesvirus vaccine

scientific article published on 01 December 2001

Priming with CpG-enriched plasmid and boosting with protein formulated with CpG oligodeoxynucleotides and Quil A induces strong cellular and humoral immune responses to hepatitis C virus NS3.

scientific article published on June 2004

Priming with DNA encoding E2 and boosting with E2 protein formulated with CpG oligodeoxynucleotides induces strong immune responses and protection from Bovine viral diarrhea virus in cattle

scientific article published on October 2006

Protection of cattle from BHV-1 infection by immunization with recombinant glycoprotein gIV.

scientific article published in January 1993

Protection of cattle from bovine herpesvirus type I (BHV-1) infection by immunization with individual viral glycoproteins

scientific article

Protection of neonates and infants by maternal immunization

scientific article published on June 2016

Protective immunity in cattle following vaccination with conventional and marker bovine herpesvirus-1 (BHV1) vaccines

scientific article published on January 1997

Rationale and perspectives on the success of vaccination against bovine herpesvirus-1.

scientific article

Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals

scientific article

Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1.

scientific article published on 11 February 2015

Respiratory disease caused by Mycoplasma bovis is enhanced by exposure to bovine herpes virus 1 (BHV-1) but not to bovine viral diarrhea virus (BVDV) type 2.

scientific article published on November 2011

Retro-inversion enhances the adjuvant and CpG co-adjuvant activity of host defence peptide Bac2A

scientific article published on 01 March 2010

Selection of adjuvants for vaccines targeting specific pathogens

scientific article published on 22 April 2019

Sequence and expression of a bovine herpesvirus-1 gene homologous to the glycoprotein K-encoding gene of herpes simplex virus-1.

scientific article published in February 1996

Strategies for improved formulation and delivery of DNA vaccines to veterinary target species

scientific article published in June 2004

Structural, functional, and immunological characterization of bovine herpesvirus-1 glycoprotein gl expressed by recombinant baculovirus

scientific article published on September 1992

Suppository-mediated DNA immunization induces mucosal immunity against bovine herpesvirus-1 in cattle

scientific article

Synthesis and processing of bovine herpesvirus 1 glycoproteins

scientific article published on August 1986

Synthesis, cellular location, and immunogenicity of bovine herpesvirus 1 glycoproteins gI and gIII expressed by recombinant vaccinia virus

scientific article published on May 1989

TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.

scientific article

Targeting with bovine CD154 enhances humoral immune responses induced by a DNA vaccine in sheep

scientific article published on January 2003

The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis

scientific article published on 17 July 2018

The bovine herpesvirus-1 major tegument protein, VP8, interacts with host HSP60 concomitant with deregulation of mitochondrial function

scientific article published on 11 December 2018

The bovine viral diarrhea virus E2 protein formulated with a novel adjuvant induces strong, balanced immune responses and provides protection from viral challenge in cattle

scientific article published on 25 October 2014

The cell-mediated immune response induced by plasmid encoding bovine herpesvirus 1 glycoprotein B is enhanced by plasmid encoding IL-12 when delivered intramuscularly or by gene gun, but not after intradermal injection

scientific article published on 03 May 2006

The cytoplasmic domain of bovine herpesvirus 1 glycoprotein B is important for maintaining conformation and the high-affinity binding site of gB.

scientific article published on August 1996

The respiratory syncytial virus fusion protein formulated with a polymer-based adjuvant induces multiple signaling pathways in macrophages.

scientific article published on 17 March 2018

The response of aged mice to primary infection and re-infection with pneumonia virus of mice depends on their genetic background

scientific article published on 18 November 2015

The role of carbohydrate in the antigenic and immunogenic structure of bovine herpesvirus type 1 glycoproteins gI and gIV

scientific article published on 01 September 1990

The role of dendritic cells in innate and adaptive immunity to respiratory syncytial virus, and implications for vaccine development.

scientific article published on December 2012

The synthetic peptides bovine enteric β-defensin (EBD), bovine neutrophil β-defensin (BNBD) 9 and BNBD 3 are chemotactic for immature bovine dendritic cells

scientific article published on 24 June 2011

Two doses of bovine viral diarrhea virus DNA vaccine delivered by electroporation induce long-term protective immune responses

scientific article published on 5 December 2012

US3 Kinase-Mediated Phosphorylation of Tegument Protein VP8 Plays a Critical Role in the Cellular Localization of VP8 and Its Effect on the Lipid Metabolism of Bovine Herpesvirus 1-Infected Cells

scientific article published on 05 March 2019

Us3 and Us9 proteins contribute to the stromal invasion of bovine herpesvirus 1 in the respiratory mucosa

scientific article published on 18 May 2017

Use of animal models in the development of human vaccines

scientific article published on December 2007

VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling

scientific journal article

Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosis

scientific article published on 01 June 2005

Vaccination of cattle with a CpG oligodeoxynucleotide-formulated mycobacterial protein vaccine and Mycobacterium bovis BCG induces levels of protection against bovine tuberculosis superior to those induced by vaccination with BCG alone.

scientific article

Vaccine Potentiation by Combination Adjuvants ⬇️

scientific article published on 14 April 2014

Veterinary applications of DNA vaccines

scientific article published on 01 January 2000

Veterinary vaccines: alternatives to antibiotics?

scientific article published on December 2008

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