List of works - Gianfranco Alpini

A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology

scientific article

Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes ⬇️

scientific article published on November 1, 2010

After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.

scientific article

Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats.

scientific article published in October 2002

Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts

scientific article

Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation

scientific article

Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?

scientific article published in 2019

Epigenetic regulation of miR-34a expression in alcoholic liver injury.

scientific article

Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma

scientific article

Estrogens and the pathophysiology of the biliary tree

scientific article

Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡.

scientific article

Functional analysis of microRNAs in human hepatocellular cancer stem cells

scientific article

Functional heterogeneity of cholangiocytes

scientific article

Functional role of cellular senescence in biliary injury

scientific article

GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.

scientific article

Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms

scientific article

Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease

scientific article published in December 2012

Hepatocyte-specific and extra-hepatocyte actions of perilipin-2 during fatty liver disease: benefits of being extra

scientific article published on 29 January 2019

Heterogeneity of the intrahepatic biliary epithelium

scientific article

Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium

scientific article

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC)

scientific article published on 12 September 2019

Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation

scientific article

Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice

scientific article

Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway.

scientific article

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

scientific article published on 04 March 2020

Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth

scientific article

Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies.

scientific article

Neuroendocrine Changes in Cholangiocarcinoma Growth

scientific article published on 13 February 2020

Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion

scientific article

Possible application of melatonin treatment in human diseases of the biliary tract

scientific article published on 11 September 2019

Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms

scientific journal article

Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.

scientific article

Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis

scientific article

Regulation of biliary proliferation by neuroendocrine factors: implications for the pathogenesis of cholestatic liver diseases

scientific article

Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury

scientific article

Regulators of Cholangiocyte Proliferation

scientific article

Role of cholangiocytes in primary biliary cirrhosis

scientific article

Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease

scientific article

Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease.

scientific article

Role of sex hormones in the modulation of cholangiocyte function.

scientific article

Role of stem cells during diabetic liver injury

scientific article

Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats

scientific article published in May 2005

Tannic acid inhibits cholangiocyte proliferation after bile duct ligation via a cyclic adenosine 5',3'-monophosphate-dependent pathway

scientific article

Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats.

scientific article published on 29 January 2003

Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats.

scientific article

Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats

scientific article

The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis

scientific journal article

Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha

scientific article published in May 2002

Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism

scientific journal article

miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth

scientific article

List of works by Gianfranco Alpini

A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology

Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes ⬇️

After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.

Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats.

Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts

Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation

Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?

Epigenetic regulation of miR-34a expression in alcoholic liver injury.

Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma

Estrogens and the pathophysiology of the biliary tree

Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice‡.

Functional analysis of microRNAs in human hepatocellular cancer stem cells

Functional heterogeneity of cholangiocytes

Functional role of cellular senescence in biliary injury

GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.

Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms

Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease

Hepatocyte-specific and extra-hepatocyte actions of perilipin-2 during fatty liver disease: benefits of being extra

Heterogeneity of the intrahepatic biliary epithelium

Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC)

Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation

Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice

Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway.

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth

Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies.

Neuroendocrine Changes in Cholangiocarcinoma Growth

Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion

Possible application of melatonin treatment in human diseases of the biliary tract

Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms

Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.

Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis

Regulation of biliary proliferation by neuroendocrine factors: implications for the pathogenesis of cholestatic liver diseases

Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury

Regulators of Cholangiocyte Proliferation

Role of cholangiocytes in primary biliary cirrhosis

Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease

Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease.

Role of sex hormones in the modulation of cholangiocyte function.

Role of stem cells during diabetic liver injury

Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats

Tannic acid inhibits cholangiocyte proliferation after bile duct ligation via a cyclic adenosine 5',3'-monophosphate-dependent pathway

Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats.

Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats.

Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats

The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis

Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha

Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism

miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth