List of works - William L Brown

A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G.

scientific article

A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B

scientific article published on 10 September 2019

A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells.

scientific article

A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination

scientific article published on 19 December 2018

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif

scientific article

APOBEC3B Nuclear Localization Requires two Distinct N-Terminal Domain Surfaces.

scientific article

APOBEC3B and AID have similar nuclear import mechanisms

scientific article

APOBEC3B is an enzymatic source of mutation in breast cancer.

scientific article published on 06 February 2013

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

scientific article published on 23 October 2013

APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo

scientific article

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

scientific article

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

scholarly article by Daniel J Salamango published in December 2018

Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus

scientific article published on 20 December 2013

Corrigendum: APOBEC3B is an enzymatic source of mutation in breast cancer

scientific article published on 23 October 2013

Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.

scientific article published on 02 May 2013

Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

scientific article published on 12 November 2018

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G

scientific article

Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling

scientific article published on 26 August 2020

Gain-of-function assay for SARS-CoV-2 M pro inhibition in living cells

scientific article published on 09 November 2020

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

scientific article published in Nature Communications

HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators

scientific article published on 01 October 2019

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1

scientific article published on 30 May 2019

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

scientific article

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

scientific article

Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity

scientific article

Long-Term Restriction by APOBEC3F Selects Human Immunodeficiency Virus Type 1 Variants with Restored Vif Function ⬇️

scientific article published on August 4, 2010

MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets

scientific article published on 24 February 2020

Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A

scientific article

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity

article

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity

scientific article

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

scientific article

SIVmac239 Vif and Human APOBEC3B Interactions Resemble Those Between HIV-1 Vif and Human APOBEC3G.

scientific article published on 4 April 2018

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.

scientific article published on 6 February 2013

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.

scientific article published on 27 December 2017

The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer

scientific article published on 14 February 2020

The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1

scientific article published on 19 June 2019

The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction

scientific article

The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers

scientific article

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

scientific article published on 14 October 2019

The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination

scientific article (publication date: 20 July 2010)

The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.

scientific article published on 11 August 2013

List of works by William L Brown

A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G.

A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B

A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells.

A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif

APOBEC3B Nuclear Localization Requires two Distinct N-Terminal Domain Surfaces.

APOBEC3B and AID have similar nuclear import mechanisms

APOBEC3B is an enzymatic source of mutation in breast cancer.

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus

Corrigendum: APOBEC3B is an enzymatic source of mutation in breast cancer

Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.

Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G

Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling

Gain-of-function assay for SARS-CoV-2 M pro inhibition in living cells

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity

Long-Term Restriction by APOBEC3F Selects Human Immunodeficiency Virus Type 1 Variants with Restored Vif Function ⬇️

MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets

Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

SIVmac239 Vif and Human APOBEC3B Interactions Resemble Those Between HIV-1 Vif and Human APOBEC3G.

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.

The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer

The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1

The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction

The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination

The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.