Search filters

List of works by Heather L. Francis

A review of mast cells and liver disease: What have we learned?

scientific article published on 03 April 2010

Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats

scientific article published on 30 March 2006

After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.

scientific article

Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA

scientific article published on 12 April 2019

Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation.

scientific article published on 20 December 2007

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases

scientific article published on 29 January 2020

Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats.

scientific article published in October 2002

Bile acid interactions with cholangiocytes

scientific article published on June 2006

Bile acid signaling and biliary functions

scientific article

Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling

scientific article published on 13 February 2020

Biogenic amine actions on cholangiocyte function

scientific article published on September 2007

Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts

scientific article

Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis.

scientific article

Cholangiocarcinoma: Bridging the translational gap from preclinical to clinical development and implications for future therapy

scientific article published on 23 November 2020

Cholangiocarcinoma: novel therapeutic targets

scientific article published on 26 February 2020

Cholangiocyte injury and ductopenic syndromes

scientific article published on November 2007

Cholangiocytes and blood supply.

scientific article published on June 2006

Concise Review: Functional Roles and Therapeutic Potentials of Long Non-coding RNAs in Cholangiopathies

scientific article published on 20 February 2020

Correction to: Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes

scientific article published on 14 January 2020

Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver

scientific article published on 01 May 2007

Development and functional characterization of extrahepatic cholangiocyte lines from normal rats.

scientific article

Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2-/- mice

scientific article published on 13 September 2019

Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis

scientific article published on 11 May 2020

Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?

scientific article published in 2019

Ductular reaction in liver diseases: pathological mechanisms and translational significances

scientific article published on 27 December 2018

Dysregulation of vitamin D3 synthesis leads to enhanced cholangiocarcinoma growth

scientific article published on February 2013

Emerging Role of Chronic Cannabis Usage and Hyperemesis Syndrome

scientific article published on 01 September 2011

Endogenous Opioids Modulate the Growth of the Biliary Tree in the Course of Cholestasis

scientific article published on 01 May 2006

Estrogens and the pathophysiology of the biliary tree

scientific article

FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway

scientific article published on 26 September 2013

Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1

scientific article published on 23 April 2009

Fructose Promotion of Intestinal and Liver Injury: A Sugar by Any Other Name That Isn't So Sweet

scientific article published on 05 July 2019

Functional heterogeneity of cholangiocytes

scientific article

Functional role of cellular senescence in biliary injury

scientific article

Functional role of microvesicles in gastrointestinal malignancies

scientific article published on April 2013

GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.

scientific article

Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis

scientific article published on July 2007

Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms

scientific article

H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway

scientific article published on 05 March 2007

H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.

scientific article published on 13 October 2009

Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.

scientific article

Hepatocyte Autophagy: Maintaining a Toxic-Free Environment

scientific article published on 09 March 2020

Hepatocyte-specific and extra-hepatocyte actions of perilipin-2 during fatty liver disease: benefits of being extra

scientific article published on 29 January 2019

Heterogeneity of the intrahepatic biliary epithelium

scientific article

Histamine regulation of hyperplastic and neoplastic cell growth in cholangiocytes ⬇️

scientific article published on June 15, 2010

Histamine restores biliary mass following carbon tetrachloride-induced damage in a cholestatic rat model.

scientific article published on 17 December 2014

Histamine-2 Receptor Vivo-Morpholino Treatment Ameliorates Large Bile Duct Damage in Mice Deficient in ATP Binding Cassette Subfamily B Member 4 (Abcb4-/-) via Down-Regulation of cAMP/ERK Signaling

scientific article published on 03 March 2020

Increased liver localization of lipopolysaccharides in human and experimental non-alcoholic fatty liver disease

scientific article published on 06 December 2019

Indole Alleviates Diet-induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell PFKFB3

scientific article published on 17 January 2020

Inhibition of mast cell-derived histamine secretion by cromolyn sodium treatment decreases biliary hyperplasia in cholestatic rodents

scientific article

Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.

scientific article published in September 2002

Intercellular Communication between Hepatic Cells in Liver Diseases ⬇️

scientific article published on 02 May 2019

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC)

scientific article published on 12 September 2019

Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling

scientific article published on 28 August 2014

Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling.

scientific article

Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation

scientific article

Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice

scientific article

Knockout of the tachykinin receptor 1 in the Mdr2-/- mouse model of primary sclerosing cholangitis reduces biliary damage and liver fibrosis

scientific article published on 23 July 2020

Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes

scientific article published on 30 January 2019

Knockout of α-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice

article

Kupffer cells: Inflammation pathways and cell-cell interactions in alcohol-associated liver disease

scientific article published on 10 September 2020

Leptin enhances cholangiocarcinoma cell growth

scientific article published on August 2008

Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma

scientific article

Mast cells (MCs) induce ductular reaction mimicking liver injury in mice via MC-derived TGF-β1 signaling

scientific article published on 06 August 2020

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

scientific article published on 04 March 2020

Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth

scientific article

Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors.

scientific article published on 14 July 2011

Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis

scientific article published on 18 October 2019

Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats

scientific article published on 7 February 2013

Molecular mechanisms of stem cell therapy in alcoholic liver disease.

scientific article published on 15 January 2014

Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium

scientific article published on 09 February 2009

Neuroendocrine Changes in Cholangiocarcinoma Growth

scientific article published on 13 February 2020

Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms.

scientific article published on 23 May 2013

Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion

scientific article

Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function

scientific article published on October 2007

Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts

scientific article published on 28 February 2007

Organoids and spheroids as novel models for studying cholestatic liver injury and cholangiocarcinoma

scientific article published on 22 November 2020

Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth

scientific article published on 6 March 2014

Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis

scientific article published on 16 March 2019

Possible application of melatonin treatment in human diseases of the biliary tract

scientific article published on 11 September 2019

Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets

scientific article published on 22 April 2019

Pro-inflammatory signalling and gut-liver axis in non-alcoholic and alcoholic steatohepatitis: Differences and similarities along the path

scientific article published on 21 April 2020

Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms

scientific article published on 29 May 2008

Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms

scientific journal article

Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.

scientific article

Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome

scientific article published on 26 November 2018

Recent advances in the morphological and functional heterogeneity of the biliary epithelium

scientific article published on May 2013

Recent advances in the regulation of cholangiocarcinoma growth

scientific article

Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer.

scientific article published on 19 May 2011

Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury

scientific article

Regulation of the histamine/VEGF axis by miR-125b during cholestatic liver injury in mice

scientific article published on 31 December 2013

Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production

scientific article published on August 2009

Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.

scientific article

Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.

scientific article

Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis

scientific article published on 28 June 2019

Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway.

scientific article published on 28 May 2008

Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities

scientific article

Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism.

scientific article published on 2 October 2002

Taurocholate feeding to bile duct ligated rats prevents caffeic acid-induced bile duct damage by changes in cholangiocyte VEGF expression.

scientific article published on 20 February 2009

Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway

scientific article

Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats.

scientific article

The Dynamic Interplay between Mast Cells, Aging/Cellular Senescence and Liver Disease

scientific article published on 29 July 2020

The Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury

scientific article published on 01 August 2020

The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.

scientific article published on 18 July 2007

The apelin-apelin receptor axis triggers cholangiocyte proliferation and liver fibrosis during mouse models of cholestasis

scientific article published on 07 September 2020

The emerging role of cellular senescence in renal diseases

scientific article published on 08 January 2020

The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway

scientific article published on 2 October 2008

The functional role of microRNAs in alcoholic liver injury

scientific article published on 08 January 2014

Thyroid hormone inhibits biliary growth in bile duct-ligated rats by PLC/IP(3)/Ca(2+)-dependent downregulation of SRC/ERK1/2

scientific article published on 27 December 2006

Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha

scientific article published in May 2002

Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2 mice and human primary sclerosing cholangitis

scientific article published on 24 August 2018

Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism

scientific journal article

gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway

scientific article published in December 2005

Paulina is supported by:

About Paulina

Help