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List of works by Bryan L. Roth

5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice.

scientific article published on 15 March 2017

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

scientific article published on 19 January 2018

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

scientific article published on 30 April 2020

Allosteric sodium in class A GPCR signaling

scientific article

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

scientific article

Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands

scientific article published on 12 February 2014

Chemotype-selective modes of action of κ-opioid receptor agonists

scientific article published on 11 October 2013

Comprehensive characterization of the Published Kinase Inhibitor Set

scientific article

D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine

scientific article published on 18 April 2019

D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.

scientific article

Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists

scientific article published on 27 March 2019

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

scientific article published on 06 July 2020

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs

scientific article published in November 2010

Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions

scientific article published on 10 September 2020

Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging

scientific article published on 17 October 2018

Erratum: Corrigendum: The promise and peril of chemical probes

scientific article published in November 2015

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

scientific article

HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search

scientific article published in 2023

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

scientific article

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs

scientific article published on 02 December 2013

Molecular control of δ-opioid receptor signalling

scientific article

Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs

scientific article published on 03 July 2019

Nanobody-enabled monitoring of kappa opioid receptor states

scientific article published on 02 March 2020

Phosphoproteomics Illuminates Opioid Actions

scientific article published on 13 September 2018

Structural Basis for Molecular Recognition at Serotonin Receptors

scientific article

Structural Determinants of G-protein   Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

scientific article

Structural Features for Functional Selectivity at Serotonin Receptors

scientific article

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

scientific article

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

scientific article

Structural basis of ligand recognition at the human MT1 melatonin receptor

scientific article published on 24 April 2019

Structural determinants of 5-HT2B receptor activation and biased agonism

article

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

scientific article published on 17 July 2017

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

scientific article published on 3 January 2018

Structure of the human smoothened receptor bound to an antitumour agent

scientific article

Structure of the human κ-opioid receptor in complex with JDTic

scientific article

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

scientific article

Structure, function and pharmacology of human itch GPCRs

scientific article published on 17 November 2021

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

scientific article

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

scientific article published on 04 May 2020

The activities of drug inactive ingredients on biological targets

scientific article

The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?

scientific article

Unexplored therapeutic opportunities in the human genome

scientific article published on 23 March 2018

Unexplored therapeutic opportunities in the human genome.

scientific article published on 23 February 2018

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

scientific article published on 24 April 2019

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