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List of works by Deborah A. Lannigan

A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA ⬇️

scientific article published on August 23, 2010

Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability

scientific article

Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival

scientific article

De novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101.

scientific article published on 5 November 2014

Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

scientific article

ERα-mediated nuclear sequestration of RSK2 is required for ER+ breast cancer tumorigenesis

scientific article published on 19 January 2018

Estrogen receptor phosphorylation

scientific article (publication date: 2003)

Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction

scientific article

Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore

scientific article published on 24 May 2006

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

scientific article

Identifying requirements for RSK2 specific inhibitors

scientific article published on 01 December 2021

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors

scientific article

Improving the affinity of SL0101 for RSK using structure-based design.

scientific article

Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.

scientific article

Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor

scientific article

Novel biosensors for the detection of estrogen receptor ligands

scientific article published in August 2005

RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells

scientific article published on 2 January 2008

RSK in tumorigenesis: connections to steroid signaling

scientific article

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

scientific article

RSK2 Binding Models Delineate Key Features for Activity ⬇️

scientific article published on January 1, 2010

RSK2 and ERα comrades-in-arms in homeostasis and transformation

scientific article published on 01 November 2020

Regioselective Synthesis of a C-4'' Carbamate,C-6'' n-Pr Substituted Cyclitol Analogue of SL0101

scientific article published on 03 February 2020

Ribosomal S6 kinase (RSK) modulators: a patent review

scientific article

Stereoselective Synthesis and Evaluation of C6″-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2.

scientific article

Structural basis for the activity of the RSK-specific inhibitor, SL0101.

scientific article

Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue

scientific article published on August 2011

Synthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols

scientific article published on 27 February 2020

Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.

scientific article published on 26 November 2014

The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4'-hydroxy

scientific article published on 01 March 2020

Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.

scientific article

pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167 ⬇️

scientific article published on April 1, 1998

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