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List of works by Vilhelm A. Bohr

14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

scientific article

3rd International Genome Dynamics in Neuroscience Conference: “DNA repair and neurological disease” ⬇️

scientific article published on July 26, 2011

A brain proteomic signature of incipient Alzheimer's disease in young <i>APOE</i> ε4 carriers identifies novel drug targets

scientific article published on 10 November 2021

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

scientific article (publication date: 4 November 2014)

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

scientific article published in PLoS ONE

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

scientific article published on 18 August 2016

A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging ⬇️

scientific article published on March 1, 2013

A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function

scientific article published on 12 June 2015

A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing

scientific article published on 30 May 2009

A research agenda for aging in China in the 21st century.

scientific article published on 21 August 2015

A role for WRN in telomere-based DNA damage responses

scholarly article

Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice

scientific article

Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair

scientific article published on 03 May 2019

Acetylation regulates WRN catalytic activities and affects base excision DNA repair

scientific article

Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins

scientific article

Acquired Localized Cutis Laxa due to Increased Elastin Turnover

scientific article published on January 2016

Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase

scientific article published on 11 July 2016

Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis

scientific article

Ageing as a risk factor for neurodegenerative disease

scientific article published on 09 September 2019

Aging, longevity and health

scientific article published on 23 July 2011

Aging-from molecules to populations

scientific article

Aprataxin localizes to mitochondria and preserves mitochondrial function ⬇️

scientific article published on April 18, 2011

Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle

scientific article published on 27 February 2019

Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis

scientific article published on 6 March 2018

BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.

scientific article published on 10 October 2013

Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease

scientific article published on 8 January 2014

Base excision repair capacity in mitochondria and nuclei: tissue-specific variations

scientific article published in December 2002

Base excision repair in the mammalian brain: Implication for age related neurodegeneration ⬇️

scientific article published on 02 May 2013

Base excision repair of oxidative DNA damage and association with cancer and aging

scientific article published on 31 October 2008

Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

scientific article

Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans

scientific article published on 18 June 2008

Biological sex and DNA repair deficiency drive Alzheimer's disease via systemic metabolic remodeling and brain mitochondrial dysfunction

scientific article published on 24 April 2020

CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice

scientific article published on 06 October 2021

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice.

scientific article published on 16 January 2013

Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal

scientific article

Cellular dynamics and modulation of WRN protein is DNA damage specific

scientific article

Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage ⬇️

scientific article published on December 1, 2003

Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity.

scientific article published on 07 January 2014

Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates

scientific article

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

scientific article published on 18 October 2016

Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation

scientific article published on 01 March 2020

Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging

scientific article published on 01 September 2019

Cockayne syndrome group B protein has novel strand annealing and exchange activities.

scientific article

Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal

scientific article

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.

scientific article published on 2 April 2012

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

scientific article

Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase

scientific article

Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling

scientific article published on 09 November 2020

Cockayne syndrome, underlying molecular defects and p53 ⬇️

scientific article published on December 1, 2011

Cockayne syndrome: Clinical features, model systems and pathways

scientific article

Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

scientific article

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

scientific article

Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases.

scientific article

Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding

scientific article

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

scientific article

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.

scientific article

Corrigendum to "Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair" [DNA Repair 79 (2019) 22-31]

scientific article published on 18 July 2019

DNA Damage and Mitochondria in Cancer and Aging

scientific article published on 04 November 2020

DNA Damage, DNA Repair, Aging, and Neurodegeneration

scientific article published on 18 September 2015

DNA base excision repair activities in mouse models of Alzheimer's disease

scientific article published on 18 April 2008

DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities

scientific article

DNA damage invokes mitophagy through a pathway involving Spata18

scientific article published on 26 May 2020

DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population

scientific article published on 10 May 2013

DNA damage responses in central nervous system and age-associated neurodegeneration

scientific article

DNA damage, DNA repair, ageing and age-related disease

scientific article published on 04 March 2008

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease

scientific article published on 30 September 2016

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

scientific article

DNA repair and the accumulation of oxidatively damaged DNA are affected by fruit intake in mice

scientific article

DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks

scientific article published on 01 June 2022

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

scientific article

Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients.

scientific article

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

scientific article

Deletion of OGG1 Results in a Differential Signature of Oxidized Purine Base Damage in mtDNA Regions

scientific article published on 05 July 2019

Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis

scientific article

Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

scientific article

Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities

scientific article published on 21 September 2015

Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells

scientific article

Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells

scientific article published on 01 May 2019

Direct and indirect roles of RECQL4 in modulating base excision repair capacity

scientific article published on 29 June 2009

Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

scientific article (publication date: November 2014)

Editorial

scientific article published on 14 September 2015

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

scientific article published on June 2016

Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)

scientific article published on 01 January 2019

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice ⬇️

scientific article published on August 27, 2012

Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention

scientific article published on 05 June 2018

Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB

scientific article (publication date: 2012)

Enzymatic mechanism of the WRN helicase/nuclease.

scientific article published on January 2006

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

scientific article (publication date: 6 June 2006)

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

scientific article published on 12 January 2012

Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.

scientific article

FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species

scientific article published on 21 August 2024

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1 ⬇️

scientific article published on October 16, 2010

First US-EU DNA repair meeting: endogenous stress, National Conference Center, VA, USA, 14-18 October 2003

scientific article published on 01 May 2004

Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population

scientific article

Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein

scientific article

Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein

scientific article

Functional deficit associated with a missense Werner syndrome mutation ⬇️

scientific article published on April 11, 2013

Gene expression and DNA repair in progeroid syndromes and human aging.

scientific article

Gene expression profiling in Werner syndrome closely resembles that of normal aging

scientific article

Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome.

scientific article

Gene-specific and mitochondrial repair of oxidative DNA damage.

scientific article published on January 2006

Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.

scientific article published on 28 December 2011

Genome instability in Alzheimer disease.

scientific article published on 20 April 2016

Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product

scientific article

Heterochromatin: an epigenetic point of view in aging

scientific article published on 04 September 2020

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

scientific article published on 04 March 2020

Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation ⬇️

scientific article published on June 28, 2012

Human RECQL1 participates in telomere maintenance

scientific article

Human RECQL1 participates in telomere maintenance.

scientific article

Human RECQL5 participates in the removal of endogenous DNA damage ⬇️

scientific article published on September 12, 2012

Human RECQL5: Guarding the crossroads of DNA replication and transcription and providing backup capability ⬇️

scientific article published on April 29, 2013

Human RECQL5beta stimulates flap endonuclease 1

scientific article

Human RecQ helicases in DNA repair, recombination, and replication.

scientific article

Human embryonic stem cells have enhanced repair of multiple forms of DNA damage

scientific article published on 19 June 2008

Human exonuclease 1 (EXO1) activity characterization and its function on flap structures

scientific article

Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis

scientific article

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies

scientific article

Human premature aging, DNA repair and RecQ helicases

scientific article

Impact papers on aging in 2009.

scientific article

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

scientific article published on 22 November 2017

Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

scientific article published on 22 September 2015

Indo-US workshop on base excision DNA repair, brain function and aging ⬇️

scientific article published on April 1, 2012

Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

scientific article published on 20 May 2020

Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality

scientific article

Intrinsic ssDNA annealing activity in the C-terminal region of WRN.

scientific article

Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage

scientific article

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

scientific article

Junction of RecQ helicase biochemistry and human disease.

scientific article

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus

scientific article

LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage

scientific article published on 01 June 2021

Lamin A/C promotes DNA base excision repair

scientific article published on 01 December 2019

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

scientific article published on 16 March 2004

Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice

scientific article published in 2013

Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans

scientific article

Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy

scientific article published on 13 June 2019

Loss of NEIL1 causes defects in olfactory function in mice

scientific article published on 14 October 2014

Mammalian 8-oxoguanine DNA glycosylase 1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei

scientific article published on 18 March 2003

Mechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand

scientific article

Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver ⬇️

scientific article published on April 6, 2011

Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions

scientific article published on 02 October 2007

Metformin improves healthspan and lifespan in mice

scientific article

Mitochondria and aging

scientific article published on 17 July 2010

Mitochondria in the signaling pathways that control longevity and health span

scientific article published on 12 August 2019

Mitochondrial DNA damage and repair in neurodegenerative disorders

scientific article published on 7 May 2008

Mitochondrial DNA repair and association with aging--an update

scientific article

Mitochondrial DNA repair of oxidative damage in mammalian cells

scientific article

Mitochondrial DNA, base excision repair and neurodegeneration

scientific article

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

scientific article

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.

scientific article published on 6 July 2005

Mitochondrial base excision repair assays

scientific article

Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease

scientific article

Mitochondrial deficiency in Cockayne syndrome ⬇️

scientific article published on February 19, 2013

Mitochondrial helicases and mitochondrial genome maintenance

scientific article

Mitochondrial repair of 8-oxoguanine and changes with aging.

scientific article

Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B.

scientific article published on December 2002

Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

scientific article published on 9 February 2017

Mitophagy and DNA damage signaling in human aging

scientific article published on 07 January 2020

Mitophagy in neurodegeneration and aging.

scientific article published on 21 February 2017

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

scientific article published on 11 February 2019

Modulation of DNA base excision repair during neuronal differentiation ⬇️

scientific article published on February 1, 2013

Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain

scientific article published on 7 September 2005

Multiple RPAs make WRN syndrome protein a superhelicase.

scientific article published in May 2018

Multiple interaction partners for Cockayne syndrome proteins: Implications for genome and transcriptome maintenance ⬇️

scientific article published on 09 April 2013

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

scientific article published in October 2016

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

scientific article published on 21 November 2019

NAD+ in Aging: Molecular Mechanisms and Translational Implications

scientific article published on 9 September 2017

NAD+ in DNA repair and mitochondrial maintenance.

scientific article published in February 2017

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

scientific article published on 5 February 2018

NAD+: The convergence of DNA repair and mitophagy

scientific article published on 8 December 2016

NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress

scientific article published on 05 June 2019

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein

scientific article

Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.

scientific article

New areas of focus at workshop on human diseases involving DNA repair deficiency and premature aging

scientific article published in February 2007

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

scientific article published in March 2018

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

scientific article published on 09 March 2009

Nuclear DNA damage signalling to mitochondria in ageing

scientific article

Nucleolin Inhibits G4 Oligonucleotide Unwinding by Werner Helicase ⬇️

scientific article (publication date: 2012)

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

scientific article

Nutrition and aging

scientific article

Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

scientific article

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

scientific article

Oxidative stress and mitochondrial DNA repair: implications for NRTIs induced DNA damage

scientific article published on 01 July 2004

Oxidized guanine lesions and hOgg1 activity in lung cancer.

scientific article published in June 2005

P VI.4 Studies on the possible detection of drug-induced topoiso-merase I-DNA complexes by nucleotide excision repair

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

scientific article

Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice

scientific article

Pathways and functions of the Werner syndrome protein

scientific article

Pathways defective in the human premature aging disease Werner syndrome

scientific article published on 01 January 2002

Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene.

scientific article

Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function

scientific article

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

scientific article published on 03 August 2004

Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress

scientific article published on April 2003

Protecting the mitochondrial powerhouse.

scientific article

Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry ⬇️

scientific article published on July 2, 2012

RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity ⬇️

scientific article published on July 31, 2012

RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex

scientific article

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures ⬇️

scientific article published on October 24, 2012

RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

scientific article

RECQL4 in genomic instability and aging ⬇️

scientific article published on August 30, 2012

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

scientific article

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance

scientific journal article

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression

scientific article

RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins

scientific article published on 2 December 2015

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase

scientific article

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase

scientific article published on 23 November 2012

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction

scientific article published on 16 September 2020

Recent Advances in Understanding Werner Syndrome.

scientific article published on 28 September 2017

Recruitment and retention dynamics of RECQL5 at DNA double strand break sites.

scientific article

Regulation of WRN helicase activity in human base excision repair

scientific article published on 22 September 2004

Regulation of the human Suv3 helicase on DNA by inorganic cofactors

scientific article published on 21 November 2014

Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress

scientific article published on 03 June 2013

Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells.

scientific article

Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria

scientific article published on 9 June 2008

Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias.

scientific article

Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes

scientific article

Repair of persistent strand breaks in the mitochondrial genome ⬇️

scientific article published on November 28, 2011

Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis

scientific article published on 2 October 2017

Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging

scientific article

Roles of Werner syndrome protein in protection of genome integrity

scientific article

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability

scientific article

SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates

scientific article published on 18 May 2015

SRT1720 improves survival and healthspan of obese mice

scientific article

Sarcopenia, aging and prospective interventional strategies.

scientific article published on 31 July 2017

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model

scientific article published on 01 April 2019

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

scientific article published on 07 January 2020

Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases

scientific article

Site-specific noncovalent interaction of the biopolymer poly(ADP-ribose) with the Werner syndrome protein regulates protein functions.

scientific article published on 29 October 2012

Skin Abnormalities in Disorders with DNA Repair Defects, Premature Aging, and Mitochondrial Dysfunction

scientific article published on 19 December 2020

Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.

scientific article

Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease

scientific article published on 15 September 2020

Special issue on the segmental progeria Cockayne syndrome

scientific article

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype

scientific article

Stimulation of flap endonuclease-1 by the Bloom's syndrome protein

scientific article

Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases

scientific article

TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.

scientific article published on 15 March 2006

Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta

scientific article published on 01 January 2006

Telomere, telomerase and aging

scientific article published on 08 December 2007

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

scientific article

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

scientific journal article

The Cockayne syndrome group B protein is a functional dimer.

scientific article published in September 2005

The HRDC domain of BLM is required for the dissolution of double Holliday junctions

scientific article

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

scientific article published on 05 December 2019

The RECQL4 protein, deficient in Rothmund–Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions ⬇️

scientific article published on May 15, 2013

The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair ⬇️

scientific article published on May 28, 2013

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

scientific article

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

scientific article

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

scientific article

The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA.

scientific article

The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency ⬇️

scientific article published on June 25, 2011

The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients ⬇️

scientific article published on November 1, 2012

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability ⬇️

scientific article published on April 28, 2012

The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus

scientific article

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

scientific article

The impact of base excision DNA repair in age-related neurodegenerative diseases

scientific article published on 04 January 2015

The involvement of human RECQL4 in DNA double-strand break repair

scientific article

The mechanics of base excision repair, and its relationship to aging and disease

scientific article published on 16 November 2006

The mitochondrial theory of aging: involvement of mitochondrial DNA damage and repair

scientific article

The mitochondrial transcription factor A functions in mitochondrial base excision repair

scientific article

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

scientific article (publication date: 30 August 2002)

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

scientific article

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging.

scientific article published on 30 April 2008

The role of DNA base excision repair in brain homeostasis and disease.

scientific article published on May 2015

The role of DNA repair in brain related disease pathology ⬇️

scientific article published on May 27, 2013

The role of RecQ helicases in non-homologous end-joining

scientific article

The role of WRN in DNA repair is affected by post-translational modifications.

scientific article published on 20 November 2006

The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells

scientific article published on February 2003

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

scientific article

Toward understanding genomic instability, mitochondrial dysfunction and aging

scientific article published on 08 October 2018

Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells

scientific article published on 23 September 2014

WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

scientific article published on 25 July 2008

WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups

scientific article published on 20 December 2006

WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks

scientific article published on 2 July 2008

WRN regulates pathway choice between classical and alternative non-homologous end joining

scientific article

Werner protein stimulates topoisomerase I DNA relaxation activity ⬇️

scientific article published on November 1, 2003

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

scientific article

Werner syndrome cells escape hydrogen peroxide-induced cell proliferation arrest

scientific article published on 30 September 2004

Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients

scientific article published in July 2004

Werner syndrome protein contains three structure-specific DNA binding domains

scientific article published on 8 October 2003

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.

scientific article published on 10 May 2007

Werner syndrome resembles normal aging

scientific article

Werner syndrome resembles normal aging

Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients ⬇️

scientific article published on June 25, 2011

[DNA repair--a fundamental factor in ageing and development of cancer]

scientific article published on 01 June 2006

p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria

scientific article published in August 2004

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