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List of works by Jean-François Côté

A licensing step links AID to transcription elongation for mutagenesis in B cells

scientific article published on 28 March 2018

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

scientific article

ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs

scientific article published on 05 June 2021

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

scientific article published on 17 July 2020

AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer

article

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

scientific article

An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling

scientific article

Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

scientific article published on 01 March 2020

Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion

scientific article

Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.

scientific article published on 9 June 2017

Cell biology. Two lipids that give direction

scientific article published on April 2009

ClipR-59 interacts with Elmo2 and modulates myoblast fusion

scientific article

DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.

scientific article published on 9 September 2010

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation

scientific article

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation

scientific article

ELMO Recruits Actin Cross-linking Family 7 (ACF7) at the Cell Membrane for Microtubule Capture and Stabilization of Cellular Protrusions ⬇️

scientific article published on November 26, 2012

Elmo2 Is a Regulator of Insulin-dependent Glut4 Membrane Translocation.

scientific article published on 20 May 2016

Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development

scientific article

Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1–induced collective directional migration and angiogenic sprouting ⬇️

scientific article published on August 30, 2012

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates

scientific article

GEF what? Dock180 and related proteins help Rac to polarize cells in new ways

scientific article

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

scientific article published on 12 April 2018

GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

scientific article published on 02 December 2021

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

scientific article published on 20 March 2019

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

scientific article published on 25 January 2018

Insights into the biological functions of Dock family guanine nucleotide exchange factors

scientific article published on March 2014

Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

scientific article published on 23 December 2019

NSCLC metastasis: going with ELMO3.

scientific article published on August 2014

Nck2 Deficiency in Mice Results in Increased Adiposity Associated With Adipocyte Hypertrophy and Enhanced Adipogenesis

scientific article published on 20 June 2016

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

scientific article published on 01 August 2020

Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex

scientific article published on September 2011

Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis

scientific article published on 26 October 2010

Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation

scientific article published on 29 January 2013

Polarized Dock Activity Drives Shh-Mediated Axon Guidance

scientific article published on 02 August 2018

Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis

scientific article published on 16 April 2013

Rac1 activation in podocytes induces the spectrum of nephrotic syndrome

scientific article published on 5 May 2017

Ras GTPases' interaction with effector domains: Breaking the families' barrier

scientific article

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice

scientific article published on 28 August 2018

Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression

scientific article published on 20 August 2020

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

scientific article published in Nature Communications

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state

scientific article published on 10 July 2020

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.

scientific article

The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family

scientific article

The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation

scientific article published on 28 January 2018

The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo

scientific article

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

scientific article published in May 2018

The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance

scientific article published on 16 August 2019

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