List of works - Bernard Gallez

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

scientific article

A mitochondrial switch promotes tumor metastasis.

scientific article

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

scientific article

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

scientific article published in August 2004

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

scientific article

Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions

scientific article

Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment.

scientific article published in January 2005

Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy.

scientific article published on 29 August 2014

The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors

scientific article published in February 2006

Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors

scientific article published on 2 December 2011

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1

scientific article published on 01 November 2010

Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice

scientific article published on September 2013

Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: a comparison with OxyLite, EPR oximetry and 19F-MRI relaxometry

scientific article published on 6 June 2012

Nitric oxide delivery to cancer: why and how?

scientific article published on 17 January 2009

Effect of anesthesia on the signal intensity in tumors using BOLD-MRI: comparison with flow measurements by Laser Doppler flowmetry and oxygen measurements by luminescence-based probes

scientific article published in September 2004

Caveolin-1 is critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and mural cell recruitment

scientific article

Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study

scientific article published on June 2005

Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation.

scientific article published on 2 November 2015

Comparison of methods for measuring oxygen consumption in tumor cells in vitro.

scientific article published on 18 September 2009

Mapping of oxygen by imaging lipids relaxation enhancement: a potential sensitive endogenous MRI contrast to map variations in tissue oxygenation

scientific article

Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif

scientific article

Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment

scientific article

Hexafluorobenzene in comparison with perfluoro-15-crown-5-ether for repeated monitoring of oxygenation using 19F MRI in a mouse model

scientific article published on 22 March 2012

Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption

scientific article

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study

scientific article

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action

scientific article

Assessing Tumor Oxygenation for Predicting Outcome in Radiation Oncology: A Review of Studies Correlating Tumor Hypoxic Status and Outcome in the Preclinical and Clinical Settings

scientific article published on 25 January 2017

Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses

scientific article

In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors

scientific article

Potentiation of radiation-induced regrowth delay by isosorbide dinitrate in FSaII murine tumors

scientific article

Qualification of a noninvasive magnetic resonance imaging biomarker to assess tumor oxygenation

scientific article

Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism

scientific article

Use of botulinum toxins in cancer therapy

scientific article published on February 2007

Botulinum toxin potentiates cancer radiotherapy and chemotherapy

scientific article published on 01 February 2006

Influence of cell detachment on the respiration rate of tumor and endothelial cells

scientific article

Manipulation of tumor oxygenation and radiosensitivity through modification of cell respiration. A critical review of approaches and imaging biomarkers for therapeutic guidance

scientific article published on 11 January 2017

Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms

scientific article published on 09 February 2010

In vivo mapping of tumor oxygen consumption using (19)F MRI relaxometry

scientific article published on 3 October 2010

Monitoring Combretastatin A4-induced tumor hypoxia and hemodynamic changes using endogenous MR contrast and DCE-MRI

scientific article published on 12 March 2015

Monitoring Tumor Response to Carbogen Breathing by Oxygen-Sensitive Magnetic Resonance Parameters to Predict the Outcome of Radiation Therapy: A Preclinical Study

scientific article

Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors.

scientific article

Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: a rationale for combination with radiation therapy.

scientific article

Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence.

scientific article published on March 2014

Magnetic targeting of paclitaxel-loaded poly(lactic--glycolic acid)-based nanoparticles for the treatment of glioblastoma

Electron paramagnetic resonance highlights that the oxygen effect contributes to the radiosensitizing effect of paclitaxel

scientific article

Nitrosylated hemoglobin levels in human venous erythrocytes correlate with vascular endothelial function measured by digital reactive hyperemia

scientific article

Multimodal imaging of tumor response to sorafenib combined with radiation therapy: comparison between diffusion-weighted MRI, choline spectroscopy and 18F-FLT PET imaging.

scientific article published on May 2013

Optimization of tumor radiotherapy with modulators of cell metabolism: toward clinical applications

scientific article published on October 2013

List of works by Bernard Gallez

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

A mitochondrial switch promotes tumor metastasis.

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions

Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment.

Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy.

The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors

Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1

Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice

Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: a comparison with OxyLite, EPR oximetry and 19F-MRI relaxometry

Nitric oxide delivery to cancer: why and how?

Effect of anesthesia on the signal intensity in tumors using BOLD-MRI: comparison with flow measurements by Laser Doppler flowmetry and oxygen measurements by luminescence-based probes

Caveolin-1 is critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and mural cell recruitment

Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study

Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation.

Comparison of methods for measuring oxygen consumption in tumor cells in vitro.

Mapping of oxygen by imaging lipids relaxation enhancement: a potential sensitive endogenous MRI contrast to map variations in tissue oxygenation

Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif

Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment

Hexafluorobenzene in comparison with perfluoro-15-crown-5-ether for repeated monitoring of oxygenation using 19F MRI in a mouse model

Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action

Assessing Tumor Oxygenation for Predicting Outcome in Radiation Oncology: A Review of Studies Correlating Tumor Hypoxic Status and Outcome in the Preclinical and Clinical Settings

Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses

In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors

Potentiation of radiation-induced regrowth delay by isosorbide dinitrate in FSaII murine tumors

Qualification of a noninvasive magnetic resonance imaging biomarker to assess tumor oxygenation

Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism

Use of botulinum toxins in cancer therapy

Botulinum toxin potentiates cancer radiotherapy and chemotherapy

Influence of cell detachment on the respiration rate of tumor and endothelial cells

Manipulation of tumor oxygenation and radiosensitivity through modification of cell respiration. A critical review of approaches and imaging biomarkers for therapeutic guidance

Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms

In vivo mapping of tumor oxygen consumption using (19)F MRI relaxometry

Monitoring Combretastatin A4-induced tumor hypoxia and hemodynamic changes using endogenous MR contrast and DCE-MRI

Monitoring Tumor Response to Carbogen Breathing by Oxygen-Sensitive Magnetic Resonance Parameters to Predict the Outcome of Radiation Therapy: A Preclinical Study

Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors.

Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: a rationale for combination with radiation therapy.

Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence.

Magnetic targeting of paclitaxel-loaded poly(lactic--glycolic acid)-based nanoparticles for the treatment of glioblastoma

Electron paramagnetic resonance highlights that the oxygen effect contributes to the radiosensitizing effect of paclitaxel

Nitrosylated hemoglobin levels in human venous erythrocytes correlate with vascular endothelial function measured by digital reactive hyperemia

Multimodal imaging of tumor response to sorafenib combined with radiation therapy: comparison between diffusion-weighted MRI, choline spectroscopy and 18F-FLT PET imaging.

Optimization of tumor radiotherapy with modulators of cell metabolism: toward clinical applications