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List of works by Donna M Wilcock

APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature

scientific article published on July 2013

Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence

scientific article

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

scientific article published on January 2016

Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease

scientific article published on June 2009

An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia.

scientific article published on 9 December 2017

Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials.

scientific article published on December 2008

Are inflammatory profiles the key to personalized Alzheimer's treatment?

scientific article published on January 2013

Assessing activation states in microglia

scientific article published on April 2010

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

scientific article published in 2023

Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages

scientific article published on 26 September 2016

Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia

scientific article published on 01 January 2019

Brain arteriolosclerosis

scientific article published on 24 October 2020

Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function

scientific article published on 19 May 2016

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

scientific article published on 16 November 2015

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunitie

scientific article published on 03 August 2020

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

scientific article published in May 2006

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

scientific article

Diagnostic and Prognostic Laboratory Testing for Alzheimer Disease

scientific article published on 01 September 2020

Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques

scientific article published on 01 January 2018

Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1 - 42 and Hypertension

scientific article published on 01 January 2018

Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses

scientific article published on 30 November 2011

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

scientific article

Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics

scientific article

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice

scientific article

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology ⬇️

scientific article published on July 25, 2012

Erratum: correction: Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

scientific article published in Nature

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia

scientific article published on 19 May 2019

Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities.

scientific article published on 5 January 2018

Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers

scientific article published on 06 February 2020

Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)

scientific article published on 9 December 2015

Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia

scholarly article by Brittani R Price et al published 2018 in Frontiers in Aging Neuroscience

Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain

scientific article published in November 2017

Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice

scientific article published on March 2009

Increased fibrillar beta-amyloid in response to human clq injections into hippocampus and cortex of APP+PS1 transgenic mice

scientific article

Induction of Hyperhomocysteinemia Models Vascular Dementia by Induction of Cerebral Microhemorrhages and Neuroinflammation ⬇️

scientific article published on January 30, 2013

Infectious hypothesis of Alzheimer disease

scientific article published on 12 November 2020

Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord

scientific article

Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

scientific article published on 10 May 2006

Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice

scientific article

Intracranial injection of Gammagard, a human IVIg, modulates the inflammatory response of the brain and lowers Aβ in APP/PS1 mice along a different time course than anti-Aβ antibodies

scientific article published on June 2013

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation ⬇️

scientific article published on May 1, 2003

Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype

scientific article

Matrix Metalloproteinase in Blood-Brain Barrier Breakdown in Dementia

scientific article

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

scientific article published in February 2004

Neuroinflammatory phenotype in early Alzheimer's disease

scientific article published on 9 October 2012

Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1

scientific article published on 25 October 2012

Noninvasive characterization of Alzheimer's disease by circulating, cell-free messenger RNA next-generation sequencing

scientific article published on 09 December 2020

Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.

scientific article

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

scientific article published in July 2004

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

scientific article

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

scientific article published on 13 December 2018

Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

scientific article

Post-acquisition processing confounds in brain volumetric quantification of white matter hyperintensities

scientific article published on 10 August 2019

Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging

scientific article published on 06 December 2019

Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2

scientific article published on February 2008

Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain

scientific article published in January 2006

Reduced Efficacy of Anti-Aβ Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity

scientific article published on September 2016

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

scientific article

The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.

scientific article published on December 2008

The roles of inflammation and immune mechanisms in Alzheimer's disease

scientific article published on 30 May 2016

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

scientific article published on 14 August 2020

Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events

scientific article published on 30 December 2019

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

journal article published in 2002

Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID).

scientific article published on 24 November 2016

Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

scientific article

Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice

scientific article published in January 2006

Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection

scientific article published on 25 October 2006

Vascular Contributions to Cognitive Impairment and Dementia: Topical Review of Animal Models.

scientific article published on 14 June 2016

Vascular contributions to cognitive impairment and dementia (VCID)

scientific article published on 26 February 2016

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

scientific article

White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups

scientific article published on 19 July 2019

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

article

mNos2 deletion and human NOS2 replacement in Alzheimer disease models

scientific article

β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

scientific article

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