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List of works by Shyamala Maheswaran

A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer

scientific article published on 13 August 2018

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

scientific article (publication date: 2 April 2010)

A conduit to metastasis: circulating tumor cell biology

scientific article published in September 2017

A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression

scientific article published on August 2009

A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases

scientific article published on 03 April 2013

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

scientific article published on 18 May 2015

A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells

scientific article published on 10 February 2020

AR Expression in Breast Cancer CTCs Associates with Bone Metastases.

scientific article published on 16 February 2018

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.

scientific article published on 27 February 2017

Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers

scientific article

An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer

scientific article published on 4 January 2018

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma.

scientific article published on 17 January 2017

Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.

scientific article

Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer

scientific article

Bevacizumab terminates homeobox B9-induced tumor proliferation by silencing microenvironmental communication

scientific article

Biodegradable nano-films for capture and non-invasive release of circulating tumor cells.

scientific article published on 20 June 2015

Biopolymer System for Cell Recovery from Microfluidic Cell Capture Devices ⬇️

scientific article published on April 3, 2012

Blood-based monitoring identifies acquired and targetable driver HER2 mutations in endocrine-resistant metastatic breast cancer

scientific article published on 16 July 2019

Brain tumor cells in circulation are enriched for mesenchymal gene expression

scientific article

COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis

scientific article published on 28 February 2019

Cancer metastasis through the prism of epithelial-to-mesenchymal transition in circulating tumor cells

scientific article

Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.

scientific article

Cell fate: Transition loses its invasive edge

scientific article published on 11 November 2015

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis

scientific article

Circulating tumor cells: approaches to isolation and characterization ⬇️

scientific article published on February 7, 2011

Clusters of Circulating Tumor Cells: a Biophysical and Technological Perspective

scientific article published on 10 August 2017

Clusters of circulating tumor cells traverse capillary-sized vessels

scientific article

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

scientific article published on 15 August 2019

Deformability of Tumor Cells versus Blood Cells

scientific article

Deformability-based cell selection with downstream immunofluorescence analysis

scientific article published on 21 March 2016

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

scientific article published on 06 February 2020

Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease

scientific article published on 13 September 2018

Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses

scientific article published on 7 October 2015

Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1

scientific article

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition

scientific article published on 28 September 2015

Enhanced purification and production of Müllerian inhibiting substance for therapeutic applications.

scientific article published on December 2003

Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma

scientific article published on 16 December 2019

Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy

scientific article published on 21 May 2015

Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer

scientific article published in October 2004

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination.

scientific article published on 09 February 2017

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition.

scientific article published in December 2016

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

scientific article

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts.

scientific article published on 26 February 2018

HER2 expression identifies dynamic functional states within circulating breast cancer cells

scientific article published on 24 August 2016

HIF1A signaling selectively supports proliferation of breast cancer in the brain

scientific article published on 09 December 2020

HOXB9 Expression Promoting Tumor Cell Proliferation and Angiogenesis Is Associated with Clinical Outcomes in Breast Cancer Patients ⬇️

scientific article published on 07 March 2012

HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis

scientific article

Highly Multiplexed Fluorescence in Situ Hybridization for in Situ Genomics

scientific article published on 09 March 2019

Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.

scientific article published on 19 September 2011

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

scholarly article

Identification of somatically acquired BRCA1/2 mutations by cfDNA analysis in patients with metastatic breast cancer

scientific article published on 22 June 2020

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms

scientific article published on 31 August 2017

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms

scientific article published on 01 October 2018

In-flow measurement of cell-cell adhesion using oscillatory inertial microfluidics

scientific article published on 17 April 2020

Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.

scientific article published on April 2013

Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways

scientific article

Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer

scientific article

Isolation and molecular characterization of circulating melanoma cells

scientific article

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

scientific article

Isolation of rare circulating tumour cells in cancer patients by microchip technology

scientific article

Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors

scientific article published on 14 April 2009

Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein

scientific article published on July 2006

MAPK7 Regulates EMT Features and Modulates the Generation of CTCs

scientific article published on 12 February 2015

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry

scientific article

Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes

scientific article published on 14 January 2020

Microfluidic isolation of platelet-covered circulating tumor cells.

scientific article published on 21 September 2017

Microfluidic, marker-free isolation of circulating tumor cells from blood samples

scientific article

Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy

scientific article published on 16 February 2018

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells

scientific article published on 7 September 2017

Mullerian Inhibiting Substance Promotes Interferon γ-induced Gene Expression and Apoptosis in Breast Cancer Cells ⬇️

scientific article published on October 7, 2003

Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells

scientific article published on December 2003

Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.

scientific article

Mullerian inhibiting substance regulates androgen-induced gene expression and growth in prostate cancer cells through a nuclear factor-kappaB-dependent Smad-independent mechanism

scientific article published on June 2006

Mullerian-inhibiting substance induces Gro-beta expression in breast cancer cells through a nuclear factor-kappaB-dependent and Smad1-dependent mechanism

scientific article published on March 2007

Mullerian-inhibiting substance regulates NF–κB signaling in the prostatein vitroandin vivo ⬇️

scientific article published on January 2, 2002

Mutually antagonistic effects of androgen and activin in the regulation of prostate cancer cell growth

scientific article published on 18 December 2003

On the trail of invasive cells in breast cancer

scientific article published in February 2018

Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

scientific article published on 03 July 2020

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

scientific article

Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions

scientific article

Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring

scientific article published on 01 January 2020

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis ⬇️

scientific article published on July 26, 2012

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

scientific article

SETD1A induced miRNA network suppresses the p53 gene expression module

scientific article published on 11 February 2016

SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.

scientific article

SETD1A protects from senescence through regulation of the mitotic gene expression program

scientific article published on 28 June 2019

Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity

scientific article

Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells

scientific article

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

scientific article published on 30 May 2019

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma ⬇️

scientific article published on July 31, 2013

The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis

scientific article published on December 2013

The Role of Physical Stabilization in Whole Blood Preservation.

scientific article published on 15 February 2016

The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor

scientific article published in April 2008

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.

scientific article

The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers

scientific article

The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis

scientific article published on 17 November 2020

Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells

scientific article published on 15 January 2015

Ultra-fast vitrification of patient-derived circulating tumor cell lines.

scientific article published on 23 February 2018

Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells

scientific article published on 08 July 2020

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish

scientific article published on 25 April 2019

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells.

scientific article published on 23 November 2017

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