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List of works by Jark Böttcher

A ligand discovery toolbox for the WWE domain family of human E3 ligases

scientific article published in 2024

BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition

scientific article published on 19 August 2020

Drugging all RAS isoforms with one pocket

scientific article published on 11 August 2020

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

scientific article published on 08 July 2019

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

scientific article published on 22 July 2021

Ligandability assessment of the C‐terminal Rel‐homology domain of NFAT1

scientific article published in 2024

Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance

scientific article published on 05 February 2020

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

scientific article published on 16 November 2020

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