List of works - Yvonne M W Janssen-Heininger

A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation

scientific article published in June 2003

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice

scientific article published on April 2016

Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation

scientific article published on 10 June 2010

Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice

scientific article published on March 2016

Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation

scientific article

Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling

scientific article

Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen

scientific article

Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses

scientific article published on 17 November 2015

Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways

scientific article

Biochemistry of asthma

scientific article published on 01 November 2011

Catalase overexpression fails to attenuate allergic airways disease in the mouse

scientific article

Cigarette smoke targets glutaredoxin 1, increasing s-glutathionylation and epithelial cell death.

scientific article published on 31 March 2011

Cooperation between classical and alternative NF-κB pathways regulates proinflammatory responses in epithelial cells.

scientific article

DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma

scientific article

Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense

scientific article

Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury

scientific article published on 9 November 2009

Dual Oxidase–1 Is Required for Airway Epithelial Cell Migration and Bronchiolar Reepithelialization after Injury ⬇️

scientific article published on December 13, 2012

Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta

scientific article

Effect of heart failure on the regulation of skeletal muscle protein synthesis, breakdown, and apoptosis

scientific article published on 11 February 2003

Emerging mechanisms of glutathione-dependent chemistry in biology and disease

scientific article published on September 2013

Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis ⬇️

scientific article published on March 1, 2003

Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner

scientific article published on 11 August 2003

Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

scientific article

Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling

scientific article

Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease ⬇️

scientific article published on June 29, 2012

Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia.

scientific article published on February 2014

Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells

scientific article published on 26 March 2016

Hydrogen peroxide as a damage signal in tissue injury and inflammation: murderer, mediator, or messenger?

scientific article

Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase

scientific article published on 25 August 2003

Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells

scientific article published on 15 January 2014

In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization.

scientific article published on July 2009

In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation

scientific article

In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization.

scientific article published on 20 February 2006

Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics.

scientific article published on February 2013

Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1).

scientific article

Influenza Induces Endoplasmic Reticulum Stress, Caspase-12–Dependent Apoptosis, and c-Jun N-Terminal Kinase–Mediated Transforming Growth Factor–β Release in Lung Epithelial Cells ⬇️

scientific article published on July 28, 2011

Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration

scientific article

Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation

scientific article published on 14 September 2005

Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice

scientific article

JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.

scientific article published on 02 September 2016

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1

scientific article

Modulation of NF-κB and Hypoxia-Inducible Factor−1 byS-Nitrosoglutathione Does Not Alter Allergic Airway Inflammation in Mice ⬇️

scientific article published on August 6, 2010

Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease

scientific article published on 15 September 2006

Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung

scientific article

Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation

scientific article published on 22 June 2006

Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta

scientific article published on 13 December 2006

NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness

scientific article

Nitric oxide and redox signaling in allergic airway inflammation

scientific article

Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation

scholarly article

Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse

scientific article published on 05 August 2005

Nonphagocytic oxidase 1 causes death in lung epithelial cells via a TNF-RI-JNK signaling axis

scientific article published in November 2006

Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control

scientific article published on May 2009

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness

scientific article published on 8 February 2008

Oxidants are not all created equal: could hydrogen peroxide actually be good for our lungs?

scientific article published on 01 April 2009

Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis

scientific article

Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism

scientific article published on 11 January 2007

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

scientific article

Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ

scientific article published on 20 June 2010

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

scientific article

Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium

scientific article

Reactive nitrogen species block cell cycle re-entry through sustained production of hydrogen peroxide

scientific article published on 10 January 2003

Reactive nitrogen species in refractory asthma: markers or players?

scientific article published on 01 February 2008

Reactive nitrogen species-induced cell death requires Fas-dependent activation of c-Jun N-terminal kinase

scientific article published on August 2004

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas.

scientific article published on January 2009

Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death

scientific article

Redox-based regulation of signal transduction: principles, pitfalls, and promises

scientific article published on 27 March 2008

Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway

scientific article published on September 2006

Reducing protein oxidation reverses lung fibrosis

scientific article published on 09 July 2018

Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease.

scientific article published on August 2010

Rust never sleeps: The continuing story of the Iron Bolt

scientific article published on 18 June 2018

S-Glutathionylation of estrogen receptor alpha affects dendritic cell function.

scientific article published on 26 January 2018

SOD inactivation in asthma: bad or no news?

scientific article

Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation

scientific article

TGF-β1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a JNK1-dependent manner.

scientific article published on 22 February 2018

The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins

scientific article

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells.

scientific article published on 11 September 2016

The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies

scientific article published on 23 January 2017

Thiol redox chemistry: role of protein cysteine oxidation and altered redox homeostasis in allergic inflammation and asthma

scientific article

Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease

scientific article

Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways

scientific article published on September 2002

Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization

scientific article published on February 2004

c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis

scientific article published on 3 October 2008

c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.

scientific article published on 25 June 2010

List of works by Yvonne M W Janssen-Heininger

A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice

Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation

Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice

Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation

Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling

Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen

Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses

Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways

Biochemistry of asthma

Catalase overexpression fails to attenuate allergic airways disease in the mouse

Cigarette smoke targets glutaredoxin 1, increasing s-glutathionylation and epithelial cell death.

Cooperation between classical and alternative NF-κB pathways regulates proinflammatory responses in epithelial cells.

DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma

Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense

Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury

Dual Oxidase–1 Is Required for Airway Epithelial Cell Migration and Bronchiolar Reepithelialization after Injury ⬇️

Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta

Effect of heart failure on the regulation of skeletal muscle protein synthesis, breakdown, and apoptosis

Emerging mechanisms of glutathione-dependent chemistry in biology and disease

Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis ⬇️

Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner

Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling

Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease ⬇️

Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia.

Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells

Hydrogen peroxide as a damage signal in tissue injury and inflammation: murderer, mediator, or messenger?

Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase

Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells

In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization.

In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation

In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization.

Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics.

Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1).

Influenza Induces Endoplasmic Reticulum Stress, Caspase-12–Dependent Apoptosis, and c-Jun N-Terminal Kinase–Mediated Transforming Growth Factor–β Release in Lung Epithelial Cells ⬇️

Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration

Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation

Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice

JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1

Modulation of NF-κB and Hypoxia-Inducible Factor−1 byS-Nitrosoglutathione Does Not Alter Allergic Airway Inflammation in Mice ⬇️

Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease

Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung

Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation

Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta

NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness

Nitric oxide and redox signaling in allergic airway inflammation

Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation

Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse

Nonphagocytic oxidase 1 causes death in lung epithelial cells via a TNF-RI-JNK signaling axis

Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness

Oxidants are not all created equal: could hydrogen peroxide actually be good for our lungs?

Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis

Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium

Reactive nitrogen species block cell cycle re-entry through sustained production of hydrogen peroxide

Reactive nitrogen species in refractory asthma: markers or players?

Reactive nitrogen species-induced cell death requires Fas-dependent activation of c-Jun N-terminal kinase

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas.

Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death

Redox-based regulation of signal transduction: principles, pitfalls, and promises

Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway

Reducing protein oxidation reverses lung fibrosis

Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease.

Rust never sleeps: The continuing story of the Iron Bolt

S-Glutathionylation of estrogen receptor alpha affects dendritic cell function.

SOD inactivation in asthma: bad or no news?

Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation

TGF-β1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a JNK1-dependent manner.

The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells.

The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies

Thiol redox chemistry: role of protein cysteine oxidation and altered redox homeostasis in allergic inflammation and asthma

Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease