List of works - David Heckerman

Adaptation of HIV-1 to human leukocyte antigen class I

scientific article published on 25 February 2009

Additive contribution of HLA class I alleles in the immune control of HIV-1 infection

scientific article published on 21 July 2010

Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L

scientific article published on 08 October 2018

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics

scientific article

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads

scientific article

CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription

scientific article

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

scientific article published on 17 December 2006

CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control

scientific article (publication date: 2012)

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point

scientific article published on 2 July 2008

Co-operative additive effects between HLA alleles in control of HIV-1

scientific article published on 19 October 2012

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

scientific article published on 20 December 2005

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

article

Definition of the viral targets of protective HIV-1-specific T cell responses

scientific article published on 7 December 2011

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

scientific article published on 12 September 2012

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

scientific article

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1

scientific article

Extensive HLA class I allele promiscuity among viral CTL epitopes

scientific article published on September 2007

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections

scientific article published on 21 February 2007

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

scientific article

Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations

scientific article published in Science

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

scientific article

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

scientific article published on 18 June 2008

HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes

scientific article

HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome

scientific article published on 26 October 2011

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load

scientific article published on 23 April 2008

HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering

scientific article published on 25 February 2009

HLA-A7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B5703

scientific article published on 15 April 2011

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

scientific article published on 29 October 2008

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

scientific article

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

scientific article published on 11 December 2012

Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection

article

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses

scientific article published in April 2006

Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.

scientific article

Influence of HLA-C expression level on HIV control

scientific article published on April 2013

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection

scientific article published on 9 July 2008

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients

scientific article (publication date: December 2008)

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control

scientific article

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

scientific article

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations

scientific article

Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.

scientific article

Publisher Correction: Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L

scientific article published on 01 December 2018

Ranking of non-coding pathogenic variants and putative essential regions of the human genome

scientific article published on 20 November 2019

Rare HLA drive additional HIV evolution compared to more frequent alleles

scientific article published on March 2009

Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins

scientific article

Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

scientific article published on February 2011

Statistical resolution of ambiguous HLA typing data

scientific article

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

scientific article

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

scientific article

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1

scientific article published on 29 February 2012

List of works by David Heckerman

Adaptation of HIV-1 to human leukocyte antigen class I

Additive contribution of HLA class I alleles in the immune control of HIV-1 infection

Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads

CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point

Co-operative additive effects between HLA alleles in control of HIV-1

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

Definition of the viral targets of protective HIV-1-specific T cell responses

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1

Extensive HLA class I allele promiscuity among viral CTL epitopes

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes

HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load

HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering

HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses

Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.

Influence of HLA-C expression level on HIV control

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations

Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.

Publisher Correction: Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L

Ranking of non-coding pathogenic variants and putative essential regions of the human genome

Rare HLA drive additional HIV evolution compared to more frequent alleles

Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins

Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

Statistical resolution of ambiguous HLA typing data

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1

HLA-A7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B5703