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List of works by Leo A.B. Joosten

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In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes

scientific article published on 12 October 2016
The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses

scientific article
Trained immunity: A smart way to enhance innate immune defence

scientific article
Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses

scientific article published on 04 November 2010
The Candida Th17 response is dependent on mannan- and beta-glucan-induced prostaglandin E2.

scientific article published on 8 November 2010
Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

scientific article published on 03 February 2015
Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models

scientific article published on October 1, 2003
Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction

scientific article
Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4

scientific article
Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

scientific article published on 12 May 2016
Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis

scholarly article by Leo A B Joosten et al published 1 February 2003 in Arthritis and Rheumatism
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

scientific article published on 08 September 2014
Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia

scientific article
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

scientific article published on 01 December 2016
Th17 responses and host defense against microorganisms: an overview

scientific article published on December 2009
Inflammatory Role of ASC in Antigen-Induced Arthritis Is Independent of Caspase-1, NALP-3, and IPAF

scientific article published on 28 August 2009
Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response.

scientific article
Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses

scientific article
Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1.

scientific article published in March 2005
Variable recognition of Candida albicans strains by TLR4 and lectin recognition receptors.

scientific article published in November 2010
Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis

scientific article
The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue

scientific article published on August 23, 2011
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis

scholarly article
Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study

scientific article published on 5 December 2011
Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.

scientific article
Innate immune memory: Implications for host responses to damage‐associated molecular patterns

scientific article published on 11 March 2016
Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death

scientific article published on 09 August 2012
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

scientific article published on 29 January 2018
Interleukin-1β in innate inflammation, autophagy and immunity

scientific article published on November 22, 2013
Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia

scientific article published on 18 January 2011
A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis.

scientific article published on 15 July 2010
The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

scientific article published in May 2012
Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation

scientific article
Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

scientific article published on 12 October 2016
The interplay between central metabolism and innate immune responses

scientific article published on 23 June 2014
T cell dependence of chronic destructive murine arthritis induced by repeated local activation of toll-like receptor–driven pathways: Crucial role of both interleukin-1β and interleukin-17

scientific article published on 01 January 2008
Immunometabolic circuits in trained immunity

scientific article
Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens

scientific article published on 01 January 2019
Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction

scientific article
Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation

scientific article published on 01 October 2011
Neutrophil-mediated inhibition of proinflammatory cytokine responses

scientific article published on 10 October 2012
The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

scientific article published on 20 February 2018
Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease

scientific article published on 6 September 2011
Non-specific effects of vaccines: Current evidence and potential implications

scientific article published on 11 July 2018
Enhanced interleukin-1β production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals

scientific article published on 4 July 2012
Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

scientific article
TLR1/TLR2 Heterodimers Play an Important Role in the Recognition of Borrelia Spirochetes

scientific article published on October 5, 2011
Vitamin A induces inhibitory histone methylation modifications and down-regulates trained immunity in human monocytes

Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors

scientific article published on 03 February 2014
Low induction of proinflammatory cytokines parallels evolutionary success of modern strains within the Mycobacterium tuberculosis Beijing genotype

scientific article

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