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List of works by Leo A.B. Joosten

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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

scientific article published in January 2018
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

scientific article
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

scientific article published on September 17, 2012
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

scientific article published on September 2014
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

scientific article
Trained immunity: A program of innate immune memory in health and disease.

scientific article
Human dectin-1 deficiency and mucocutaneous fungal infections

scientific article
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

scientific article published on February 2004
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

scientific article published on 22 December 2008
The effect of host genetics on the gut microbiome

scientific article published on 03 October 2016
Inflammasome is a central player in the induction of obesity and insulin resistance

scientific article
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity

scientific article published on December 2010
Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.

scientific article published on August 2012
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis

scientific article
Inflammasome activation and IL-1β and IL-18 processing during infection

scientific article published on 18 February 2011
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

scientific article published on January 2008
IL-1beta processing in host defense: beyond the inflammasomes

scientific article
Innate Immune Recognition of Mycobacterium tuberculosis

scientific article published on 07 April 2011
IL-32, a proinflammatory cytokine in rheumatoid arthritis

scholarly article
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

scientific article published on 28 May 2006
The macrophage mannose receptor induces IL-17 in response to Candida albicans.

scientific article published in April 2009
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis

scientific article published in September 2007
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.

scientific article
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta

scientific article published on December 2009
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

scientific article published on 18 February 2014
Inflammasome-independent regulation of IL-1-family cytokines

scientific article published on 10 December 2014
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

scientific article published on 16 November 2016
Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease

scientific article
Immune defence against Candida fungal infections

scientific article published on 21 September 2015
IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance

scientific article published on 01 March 2003
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

scientific article
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

scientific article published on July 2005
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis

scientific article
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma

scientific article published on 01 December 2004
Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity

scientific article published on 30 October 2013
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

scientific article
Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

scientific article
The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

scientific article published on 29 April 2011
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

scientific article published in January 2018
Immunometabolic Pathways in BCG-Induced Trained Immunity

scientific article published on December 2016
Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism

scientific article
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

scientific article published in January 2018
The inflammasome puts obesity in the danger zone

scientific article published on January 2012
IL-1 family nomenclature

scientific article
Interplay between Candida albicans and the mammalian innate host defense.

scientific article published on 17 January 2012
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

scientific article published on 6 February 2012
Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

scientific article published on 05 June 2014
Citrullination of synovial proteins in murine models of rheumatoid arthritis

scientific article published in September 2003
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

scientific article published on October 25, 2014
TNF-induced structural joint damage is mediated by IL-1.

scholarly article

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