List of works - Clara C Posthuma

A complex zinc finger controls the enzymatic activities of nidovirus helicases

scientific article published on January 2005

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors

scientific article published on 28 August 2019

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model

scientific article published on 10 November 2016

An infectious recombinant equine arteritis virus expressing green fluorescent protein from its replicase gene

scientific article published on April 2007

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive

scientific article published on 22 October 2015

Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins

scientific article published on 3 June 2015

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

scientific article

Cyclophilins and cyclophilin inhibitors in nidovirus replication

scientific article published on 12 July 2018

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

scientific article published on 23 May 2015

Discontinuous subgenomic RNA synthesis in arteriviruses is guided by an RNA hairpin structure located in the genomic leader region

scientific article published on May 2005

Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production

scientific article

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

scientific article published on 24 August 2015

Expression of the xylulose 5-phosphate phosphoketolase gene, xpkA, from Lactobacillus pentosus MD363 is induced by sugars that are fermented via the phosphoketolase pathway and is repressed by glucose mediated by CcpA and the mannose phosphoenolpyru

scientific article published on February 2002

Formation of the Arterivirus Replication/Transcription Complex: a Key Role for Nonstructural Protein 3 in the Remodeling of Intracellular Membranes

scientific article (publication date: May 2008)

Inducing fluorescence of uranyl acetate as a dual-purpose contrast agent for correlative light-electron microscopy with nanometre precision.

scientific article published on 5 September 2017

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

scientific article

Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm09 virus.

scientific article

Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus.

scientific article

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

scientific article

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

scientific article

Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle.

scientific article

Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase ⬇️

scientific article

Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7α

scientific article

The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle

scientific article

What we know but do not understand about nidovirus helicases

scientific article

List of works by Clara C Posthuma

A complex zinc finger controls the enzymatic activities of nidovirus helicases

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model

An infectious recombinant equine arteritis virus expressing green fluorescent protein from its replicase gene

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive

Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Cyclophilins and cyclophilin inhibitors in nidovirus replication

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

Discontinuous subgenomic RNA synthesis in arteriviruses is guided by an RNA hairpin structure located in the genomic leader region

Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

Expression of the xylulose 5-phosphate phosphoketolase gene, xpkA, from Lactobacillus pentosus MD363 is induced by sugars that are fermented via the phosphoketolase pathway and is repressed by glucose mediated by CcpA and the mannose phosphoenolpyru

Formation of the Arterivirus Replication/Transcription Complex: a Key Role for Nonstructural Protein 3 in the Remodeling of Intracellular Membranes

Inducing fluorescence of uranyl acetate as a dual-purpose contrast agent for correlative light-electron microscopy with nanometre precision.

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm09 virus.

Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus.

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle.

Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase ⬇️

Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7α

The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle

What we know but do not understand about nidovirus helicases