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List of works by Hiroshi Aikata

<em>In vitro</em> analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism

scientific article published on 12 November 2020

A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD.

scientific article published on 11 July 2018

A case of advanced HCC treated with lenvatinib after hepatic arterial infusion chemotherapy combined with radiation therapy treatment for portal vein tumor thrombosis in the main trunk

scientific article published on 23 January 2020

A case of chronic hepatitis C with pancreas divisum and acute pancreatitis during combination treatment with telaprevir/peginterferon/ribavirin

scientific article published in October 2014

A case of fulminant hepatic failure caused by hepatitis E virus

scientific article

A case of syndrome of inappropriate secretion of antidiuretic hormone following transarterial embolization with cisplatin

scientific article published on 01 September 2014

A case with life-threatening secondary sclerosing cholangitis caused by nivolumab

scientific article published on 16 November 2020

A first case of hepatic angiosarcoma treated with recombinant interleukin-2.

scientific article published on December 2011

A huge metastatic liver tumor from leiomyosarcoma of the inferior vena cava: report of a case

scientific article published on 30 November 2011

A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections.

scientific article published on 16 October 2013

A second attack of cholestasis associated with erythropoietic protoporphyria was successfully treated by plasma exchange and blood transfusion

scientific article published on 10 June 2014

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

scientific article published on 25 November 2021

Achievement of sustained viral response after switching treatment from pegylated interferon α-2b to α-2a and ribavirin in patients with recurrence of hepatitis C virus genotype 1 infection after liver transplantation: a case report.

scientific article published on 25 August 2011

Advanced liver fibrosis effects on the response to sofosbuvir-based antiviral therapies for chronic hepatitis C

scientific article published on 13 August 2018

Airway stenting for tracheal obstruction due to lymph node metastasis of hepatocellular carcinoma

scientific article

Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy

scientific article published in January 2010

Analysis of Post-Progression Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib

scientific article published on 03 September 2020

Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

scientific article

Assessment of Outcome of Hepatic Arterial Infusion Chemotherapy in Patients with Advanced Hepatocellular Carcinoma by the Combination of RECIST and Tumor Markers

Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.

scientific article published on 4 April 2015

Balloon-occluded retrograde transvenous obliteration for portal-systemic encephalopathy due to superior mesenteric-caval shunt via the right gonadal vein

scientific article

Balloon-occluded retrograde transvenous obliteration of gastric fundal varices with hemorrhage

scientific article published in May 2002

Beneficial effects of living-donor liver transplantation on esophageal varices

scientific article published on 24 December 2008

CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

article

Case reports of portal vein thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma

scholarly article by Shigeo Takahashi et al published October 2014 in Hepatology Research

Change in Imaging Findings on Angiography-Assisted CT During Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

scientific article published on 28 December 2015

Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.

scientific article published on 18 May 2018

Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure

scientific article published on 24 July 2018

Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy

scientific article published on 17 June 2015

Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib

scientific article published on 20 May 2020

Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.

scientific article published in May 2013

Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations

scientific article published on 26 February 2020

Clinical Usefulness of Serum Autotaxin for Early Prediction of Relapse in Male Patients with Type 1 Autoimmune Pancreatitis

scientific article published on 20 May 2020

Clinical features and prognosis in patients with hepatocellular carcinoma that developed after hepatitis C virus eradication with interferon therapy

scientific article published on 4 March 2011

Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma

scientific article

Clinical outcome and prognostic factors in hepatocellular carcinoma patients with bone metastases medicated with zoledronic acid

scientific article published on 15 November 2016

Clinical outcome and prognostic factors of patients with hepatocellular carcinoma and extrahepatic metastasis treated with sorafenib

scientific article published on 24 April 2014

Clinical outcome of esophageal varices after hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with major portal vein tumor thrombus

scientific article published on 01 November 2011

Clinical outcome of sorafenib treatment in patients with advanced hepatocellular carcinoma refractory to hepatic arterial infusion chemotherapy

scientific article published in December 2013

Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real-world practice

scientific article published on 27 May 2018

Clinical outcomes of stereotactic body radiotherapy for elderly patients with hepatocellular carcinoma

scientific article published on 24 June 2017

Clinical significance of small-bowel villous edema in patients with liver cirrhosis-a capsule endoscopy study

scientific article

Clinical utility of gadoxetate disodium-enhanced hepatic MRI for stereotactic body radiotherapy of hepatocellular carcinoma

scientific article published on 31 July 2015

Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma

scientific article published on 23 July 2008

Combination of transcatheter arterial chemoembolization using cisplatin-lipiodol suspension and percutaneous ethanol injection for treatment of advanced small hepatocellular carcinoma

scientific article published in September 2002

Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice

scientific article published on 15 January 2013

Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice.

scientific article

Combination therapy of oral fluoropyrimidine anticancer drug S-1 and interferon alpha for HCC patients with extrahepatic metastases

scientific article

Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy Combined with Radiotherapy and Sorafenib for Advanced Hepatocellular Carcinoma Patients with Major Portal Vein Tumor Thrombosis

scientific article published on 9 February 2018

Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy and Sorafenib in Patients with Hepatocellular Carcinoma Refractory to Transcatheter Arterial Chemoembolization

scientific article published on July 2016

Comparison of Stereotactic Body Radiation Therapy Combined With or Without Transcatheter Arterial Chemoembolization for Patients With Small Hepatocellular Carcinoma Ineligible for Resection or Ablation Therapies

scientific article published on 01 January 2018

Comparison of clinical outcome of hepatic arterial infusion chemotherapy and sorafenib for advanced hepatocellular carcinoma according to macrovascular invasion and transcatheter arterial chemoembolization refractory status

scientific article published on 10 May 2018

Comparison of hepatic arterial infusion chemotherapy between 5-fluorouracil-based continuous infusion chemotherapy and low-dose cisplatin monotherapy for advanced hepatocellular carcinoma

scientific article published on 23 August 2018

Comparison of hepatic arterial infusion chemotherapy versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma

scientific article published in September 2015

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

scientific article published on 21 February 2019

Complete response to pembrolizumab in advanced hepatocellular carcinoma with microsatellite instability

scientific article published on 04 February 2020

Complete response to short-term sorafenib treatment alone for hepatocellular carcinoma with bone, lymph node, and peritoneum metastases

scientific article published on 30 April 2016

Complications after Radiofrequency Ablation for Hepatocellular Carcinoma: A Multicenter Study Involving 9,411 Japanese Patients

scientific article published on 22 October 2019

Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16 346 treated nodules in 13 283 patients ⬇️

scientific article published on May 14, 2012

Correction: Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers

Correction: Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study

scientific article published on 01 January 2019

Correlation between Early Tumor Marker Response and Imaging Response in Patients with Advanced Hepatocellular Carcinoma Treated with Lenvatinib

scientific article published on 26 June 2019

Cost-effectiveness analyses of anti-HCV treatments using QOL scoring among patients with chronic liver disease in the Hiroshima prefecture.

scientific article published on 5 January 2018

Cross-over study in hyperammonemia patients for efficacy, safety, and acceptability of a new lactulose preparation (SK-1202) compared to approved drug

scientific article published on 09 August 2018

Cutaneous complications after transcatheter arterial treatment for hepatocellular carcinoma via the internal mammary artery: how to avoid this complication

scientific article published on 30 June 2011

Daclatasvir and asunaprevir treatment improves liver function parameters and reduces liver fibrosis markers in chronic hepatitis C patients

scientific article published on 17 November 2015

Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice

scientific article published on 11 January 2013

Development of hepatocellular carcinoma in patients with hepatitis C virus infection who achieved sustained virological response following interferon therapy: A large-scale, long-term cohort study.

scientific article

Differences in serum microRNA profiles in hepatitis B and C virus infection.

scientific article published on 5 November 2014

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

scientific article published on 12 March 2020

Disseminated carcinomatosis of the bone marrow originating from hepatocellular carcinoma. A case report

scientific article published on 3 September 2014

Dose comparison study of pegylated interferon-alpha-2b plus ribavirin in naïve Japanese patients with hepatitis C virus genotype 2: a randomized clinical trial

scientific article

Dynamic computed tomography appearance of tumor response after stereotactic body radiation therapy for hepatocellular carcinoma: How should we evaluate treatment effects?

scientific article

Early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated by lenvatinib therapy

scientific article published on 20 August 2019

Early experience of seven hepatocellular carcinoma cases treated with regorafenib

scientific article published on 11 October 2018

Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

scientific article published on 26 October 2015

Effects of ITPA polymorphism on decrease of hemoglobin during simeprevir, peg-interferon, and ribavirin combination treatment for chronic hepatitis C.

scientific article published on 25 February 2016

Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma

scientific article

Effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway.

scientific article published on March 2015

Efficacy and safety of daclatasvir plus asunaprevir therapy for chronic hepatitis C patients with renal dysfunction.

scientific article

Efficacy and safety of edoxaban for treatment of portal vein thrombosis following danaparoid sodium in patients with liver cirrhosis

scientific article published on 24 March 2017

Efficacy and safety of sitagliptin for the treatment of nonalcoholic fatty liver disease with type 2 diabetes mellitus

scientific article published in March 2014

Efficacy and safety of the anticoagulant drug, danaparoid sodium, in the treatment of portal vein thrombosis in patients with liver cirrhosis

scientific article

Efficacy of Lusutrombopag for Thrombocytopenia in Patients with Chronic Liver Disease Scheduled to Undergo Invasive Procedures

scientific article published on 21 October 2020

Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

scientific article published on 14 June 2019

Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma

scientific article

Efficacy of radiofrequency ablation for initial recurrent hepatocellular carcinoma after curative treatment: Comparison with primary cases

scientific article published on 28 April 2015

Efficacy of rosuvastatin for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label, pilot study

scientific article published on 14 May 2012

Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin. A prospective randomized controlled t

scientific article published in January 2007

Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease

scientific article published on 18 July 2014

Elevation of Serum Levels of Advanced Glycation End Products in Patients With Non-B or Non-C Hepatocellular Carcinoma.

scientific article published on 23 September 2014

Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice

scientific article published on 10 November 2015

Emergence of drug resistance-associated variants and changes in serum lipid profiles in sofosbuvir plus ledipasvir-treated chronic hepatitis C patients.

scientific article published on 28 June 2017

Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

scientific article published on 18 September 2018

Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery: Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and interferon-sensitivity determining

scientific article published in November 2011

Erratum to: Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy

scientific article published in January 2018

Erratum: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

scientific article published on 01 May 2016

Etiology and outcome of acute liver failure: retrospective analysis of 50 patients treated at a single center

scientific article published on 10 July 2008

Evaluation of early response to hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma using the combination of response evaluation criteria in solid tumors and tumor markers

scientific article published on 01 April 2015

Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring

scientific article

Evaluation of patients with esophageal varices after endoscopic injection sclerotherapy using multiplanar reconstruction MDCT images

scientific article

Evaluation of portosystemic collaterals by MDCT-MPR imaging for management of hemorrhagic esophageal varices

scientific article published on 14 July 2009

Evaluation of the mRECIST and α-fetoprotein ratio for stratification of the prognosis of advanced-hepatocellular-carcinoma patients treated with sorafenib

scientific article published on 11 August 2012

Exacerbation of Portal Hypertensive Enteropathy after Endoscopic Injection Sclerotherapy for Esophageal Varices

scientific article published on 01 October 2019

Extracellular water to total body water ratio obtained by bioelectrical impedance analysis determines the dose intensity of lenvatinib for the treatment of patients with advanced hepatocellular carcinoma

scientific article published on 16 December 2020

FDG positron emission tomography/computed tomography for the detection of extrahepatic metastases from hepatocellular carcinoma

scientific article published on 01 February 2009

Genetics of IL28B and HCV--response to infection and treatment

scientific article published on 29 May 2012

Genomic Characterization of Biliary Tract Cancers Identifies Driver Genes and Predisposing Mutations.

scientific article published on 19 January 2018

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

scientific article published on 02 March 2019

HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study

scientific article

Hepatectomy after down-staging of hepatocellular carcinoma with portal vein tumor thrombus using chemoradiotherapy: A retrospective cohort study

scientific article published on 01 July 2017

Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity-matched analysis in a single institution

scientific article published on 23 May 2018

Hepatic Arterial Infusion Chemotherapy versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma

scientific article published on 24 July 2020

Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial.

scientific article published on 4 June 2018

Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma according to Child-Pugh classification

scientific article published on 01 December 2012

Hepatic arterial infusion chemotherapy using 5-fluorouracil and systemic interferon-α for advanced hepatocellular carcinoma in combination with or without three-dimensional conformal radiotherapy to venous tumor thrombosis in hepatic vein or inferio

scientific article published on 16 December 2011

Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle

scientific article

Hepatocellular carcinoma treated with sorafenib: Arterial tumor perfusion in dynamic contrast-enhanced CT as early imaging biomarkers for survival

scientific article published on 4 November 2017

Hepatocellular carcinoma: towards personalized medicine.

scientific article published on 15 March 2012

Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice

scientific article

Hypersensitivity reactions to transcatheter chemoembolization with cisplatin and Lipiodol suspension for unresectable hepatocellular carcinoma

scientific article published on 01 August 2010

Hypovascular hepatic nodules showing hypointense on the hepatobiliary-phase image of Gd-EOB-DTPA-enhanced MRI to develop a hypervascular hepatocellular carcinoma: a nationwide retrospective study on their natural course and risk factors

scientific article published on 21 November 2013

IFNL4 polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C.

scientific article

ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic hepatitis C.

scientific article published on 7 November 2016

Impact of Hepatitis C Virus Eradication on the Clinical Outcome of Patients with Hepatitis C Virus-Related Advanced Hepatocellular Carcinoma Treated with Sorafenib

scientific article published on March 2017

Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection

scientific article published on 28 June 2011

Impact of viral eradication by DAAs on the risk of HCC development, prognosis and portal hypertension in HCV-related compensated cirrhosis patients

scientific article published on 06 August 2020

Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.

scientific article

Improvement of renal dysfunction in a patient with hepatitis C virus-related liver cirrhosis by daclatasvir and asunaprevir combination therapy: A case report.

scientific article

Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab

scientific article published on 23 February 2020

Inferior vena cava tumor thrombus that directly infiltrated from paracaval lymph node metastases in a patient with recurrent hepatocellular carcinoma

scientific article published on 6 August 2013

Influence of the rs738409 polymorphism in patatin-like phospholipase 3 on the treatment efficacy of non-alcoholic fatty liver disease with type 2 diabetes mellitus.

scientific article

Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers

scientific article

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

scientific article

Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C.

scientific article published on 6 May 2014

Interleukin-28B single nucleotide polymorphism of donors and recipients can predict viral response to pegylated interferon/ribavirin therapy in patients with recurrent hepatitis C after living donor liver transplantation

scientific article published on September 2012

Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease

scientific article published on July 2016

Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis

scientific article

Intra-arterial 5-fluorouracil/interferon combination therapy for hepatocellular carcinoma with portal vein tumor thrombosis and extrahepatic metastases

scientific article published on 14 January 2010

Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease.

scientific article

Is small-bowel capsule endoscopy effective for diagnosis of esophagogastric lesions related to portal hypertension?

scientific article published in March 2014

Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report

scientific article published on 28 November 2019

Late-onset ornithine transcarbamylase deficiency associated with hyperammonemia

scientific article published on 09 June 2017

Letter of response to the editor

scientific article published on 14 October 2020

Levocarnitine Use Is Associated With Improvement in Sarcopenia in Patients With Liver Cirrhosis

Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure

scientific article published on 19 June 2018

Liver fibrosis assessment by FibroScan compared with pathological findings of liver resection specimen in hepatitis C infection

scientific article published on 3 September 2016

Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C inf

scientific article published on 25 September 2020

Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy

scientific article

Long-term outcome of patients with gastric varices treated by balloon-occluded retrograde transvenous obliteration

scientific article published on 01 May 2014

Long-term outcome of stereotactic body radiotherapy for patients with small hepatocellular carcinoma

scientific article published on 14 January 2018

Long-term outcomes of hepatic arterial port implantation using a coaxial microcatheter system in 176 patients with hepatocellular carcinoma

scientific article published on 01 March 2012

Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma

scientific article

Major predictors of portal hypertensive enteropathy in patients with liver cirrhosis

scientific article published on 01 January 2015

Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis

scientific article published on 04 September 2019

Migration to the pulmonary artery of nine metallic coils placed in the internal iliac vein for treatment of giant rectal varices

scientific article

Multicentric hepatocarcinogenesis at 6 and 13 years after sustained viral response to hepatitis C virus

scientific article

Non-invasive assessment of liver steatosis in non-alcoholic fatty liver disease

scientific article

Non-invasive liver fibrosis score calculated by combination of virtual touch tissue quantification and serum liver functional tests in chronic hepatitis C patients

scientific article

Objective Response by mRECIST Is an Independent Prognostic Factor for Overall Survival in Hepatocellular Carcinoma Treated with Sorafenib in the SILIUS Trial

scientific article published on 08 October 2019

PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection, cohort study

scientific article published on 29 June 2020

PNPLA3 and HLA-DQB1 polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication

scientific article published on 15 October 2020

Patients with early recurrence of hepatocellular carcinoma have poor prognosis

scientific article

Percutaneous radiofrequency ablation as first-line treatment for small hepatocellular carcinoma: results and prognostic factors on long-term follow up.

scientific article published on 14 January 2010

Percutaneous transvenous embolization for portosystemic shunts associated with encephalopathy: Long-term outcomes in 14 patients

scientific article published on 11 July 2013

Percutaneous transvenous shunt occlusion for portosystemic encephalopathy due to lenvatinib administration to a patient with hepatocellular carcinoma and portosystemic shunt

scientific article published on 31 January 2019

Persistent Loss of Hepatitis B Virus Markers in Serum without Cellular Immunity by Combination of Peginterferon and Entecavir Therapy in Humanized Mice

scientific article published on 10 July 2017

Pilot study of stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma

article by Yohji Honda et al published 1 January 2014 in Hepato-Gastroenterology

Pilot study of systemic combination therapy with S-1, an oral fluoropyrimidine, and cisplatin for hepatocellular carcinoma with extrahepatic metastases.

scientific article

Portal-systemic shunt between the inferior mesenteric vein and inferior vena cava in a patient with hepatic encephalopathy: successful occlusion by balloon-occluded retrograde transvenous obliteration

scientific article published on 01 March 2011

Predictive Factors of Portal Hypertensive Enteropathy Exacerbation in Patients with Liver Cirrhosis: A Capsule Endoscopy Study

scientific article published on 19 April 2018

Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C.

scientific article published on 21 December 2013

Preoperative Fluorine 18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Prediction of Microvascular Invasion in Small Hepatocellular Carcinoma

scientific article published on 10 March 2016

Preoperative PET-CT is useful for predicting recurrent extrahepatic metastasis of hepatocellular carcinoma after resection

scientific article published on 11 January 2020

Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma.

scientific article

Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice

scientific article published on 2 April 2018

Prevention of recurrence of hepatocellular carcinoma with anti-viral therapy for hepatitis C virus

scientific article published on December 2015

Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation: analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus

scientific article published on 22 July 2010

Prospective study of short-term peginterferon-alpha-2a monotherapy in patients who had a virological response at 2 weeks after initiation of interferon therapy

scientific article published on 01 April 2008

Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing

scientific article published on 20 September 2016

Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis

scientific article published on 24 October 2019

Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy

scientific article published on 18 August 2014

REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: an analysis of Japanese subset

scientific article published on 12 November 2019

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial

scientific article published on 04 December 2019

Randomized trial of high-dose interferon-alpha-2b combined with ribavirin in patients with chronic hepatitis C: Correlation between amino acid substitutions in the core/NS5A region and virological response to interferon therapy

scientific article published on April 2009

Randomized, phase II trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced hepatocellular carcinoma: SCOOP-2 trial

scientific article published on 15 October 2019

Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay

scientific article

Real-word efficacy of sofosbuvir, velpatasvir plus ribavirin therapy for chronic hepatitis patients who failed to prior DAA therapy with NS5A-P32 deletion mutated HCV infection

scientific article published on 12 July 2020

Real-world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus-infected cirrhosis patients

scientific article published on 11 August 2016

Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures

scientific article published on 17 October 2018

Real-world efficacy of sofosbuvir plus velpatasvir therapy for patients with hepatitis C virus-related decompensated cirrhosis

scientific article published on 11 September 2020

Recent trend of clinical features in patients with hepatocellular carcinoma

scientific article published on 13 December 2011

Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study

scientific article published on 01 January 2018

Renal metastasis from primary hepatocellular carcinoma: a case report

scientific article published on 25 March 2020

Reply: Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity -matched analysis in a single institution

scientific article published on 22 February 2019

Retrograde venography during balloon-occluded retrograde transvenous obliteration of gastric varices

scientific article published on 13 January 2017

Retrospective Identification of Herpes Simplex 2 Virus-Associated Acute Liver Failure in an Immunocompetent Patient Detected Using Whole Transcriptome Shotgun Sequencing.

scientific article published on 26 December 2017

Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy

scientific article published on 16 October 2019

Risk factors for exacerbation of gastroesophageal varices and portosystemic encephalopathy during treatment with nucleos(t)ide analogs for hepatitis B virus-related cirrhosis

scientific article published on 8 November 2017

Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases

scientific article published on 02 January 2020

Risk factors for the exacerbation of esophageal varices or portosystemic encephalopathy after sustained virological response with IFN therapy for HCV-related compensated cirrhosis

scientific article published on 05 October 2012

Role of 3-D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

scientific article published on 19 August 2014

Safety and efficacy of dual therapy with daclatasvir and asunaprevir for older patients with chronic hepatitis C.

scientific article published on 8 September 2016

Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy.

scientific article

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse.

scientific article published on 10 July 2012

Should splenectomy be performed for hepatitis C patients undergoing living-donor liver transplantation?

scientific article published on 01 June 2007

Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

scientific article published on 09 June 2020

Significant regression of a cavernous hepatic hemangioma to a sclerosed hemangioma over 12 years: a case study

scientific article published in June 2011

Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma

scientific article published in November 2007

Sinusoidal obstruction syndrome post-treatment with trastuzumab emtansine (T-DM1) in advanced breast cancer

scientific article published on 24 October 2019

Skeletal Muscle Loss during Tyrosine Kinase Inhibitor Treatment for Advanced Hepatocellular Carcinoma Patients

scientific article published on 08 November 2019

Small bowel abnormalities in patients with compensated liver cirrhosis.

scientific article published on 18 December 2012

Sorafenib plus low-dose cisplatin and fluorouracil hepatic arterial infusion chemotherapy versus sorafenib alone in patients with advanced hepatocellular carcinoma (SILIUS): a randomised, open label, phase 3 trial

scientific article published on 07 April 2018

Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma

scientific article published in March 2013

Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies

scientific article published on 16 June 2014

Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy

scientific article published on 28 August 2019

Successful treatment of pulmonary metastases associated with advanced hepatocellular carcinoma by systemic 5-fluorouracil combined with interferon-alpha in a hemodialysis patient

scientific article published on 28 October 2008

Surgical treatment for portosystemic encephalopathy in patients with liver cirrhosis: Occlusion of portosystemic shunt in combination with splenectomy

scientific article published on 26 June 2012

Sustained virological response to antiviral therapy improves survival rate in patients with recurrent hepatitis C virus infection after liver transplantation

scientific article published on 5 November 2014

Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: seven cases

scientific article

Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

scientific article published on 26 March 2020

The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

scientific article published on 11 June 2015

The association between serum cytokine and chemokine levels and antiviral response by entecavir treatment in chronic hepatitis B patients

scientific article

The first Japanese case of COACH syndrome

scientific article

The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus.

scientific article published on 3 September 2015

The impact of interferon-free direct-acting antivirals on clinical outcome after curative treatment for hepatitis C virus-associated hepatocellular carcinoma; comparison with interferon-based therapy

scientific article published on 19 November 2018

The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration

scientific article published on 24 August 2007

The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients

scientific article published on 15 July 2016

The risk of transient postprandial oxyhypoglycemia in nonalcoholic fatty liver disease

scientific article published on 28 June 2016

The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy.

scientific article published on 10 August 2017

Third-Generation Capsule Endoscopy Outperforms Second-Generation Based on the Detectability of Esophageal Varices

scientific article

Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection

scientific article published on 06 December 2019

Three patients treated with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation: Case report

scientific article published on 6 October 2015

Three patients treated with sofosbuvir plus ledipasvir for recurrent hepatitis C after liver transplantation

scientific article published on 21 February 2017

Transarterial chemoembolization with miriplatin vs. epirubicin for unresectable hepatocellular carcinoma: a phase III randomized trial

scientific article published in August 2017

Transarterial infusion chemotherapy using cisplatin-lipiodol suspension with or without embolization for unresectable hepatocellular carcinoma

scientific article published on 15 May 2009

Transarterial therapy of hepatocellular carcinoma fed by the right renal capsular artery

scientific article published in March 2014

Transcatheter arterial chemoembolization with an interventional-CT system for recurrent hepatocellular carcinoma after living donor liver transplantation

scientific article published on 01 July 2014

Transcatheter chemoembolization for unresectable hepatocellular carcinoma and comparison of five staging systems

scientific article published on 28 September 2010

Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution

scientific article published on 12 June 2020

Treatment strategy for early hepatocellular carcinomas: comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection

scientific article published in July 2011

Trends in Hepatic Functional Reserve of Patients with Hepatocellular Carcinoma Treated with Tyrosine Kinase Inhibitors

scientific article published on 24 July 2020

Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma

scientific article published on 01 May 2020

Two patients treated with pegylated interferon/ribavirin/telaprevir triple therapy for recurrent hepatitis C after living donor liver transplantation.

scientific article published on 17 February 2014

Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients

scientific article

Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin.

scientific article

Usefulness of combining gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging and contrast-enhanced ultrasound for diagnosing the macroscopic classification of small hepatocellular carcinoma

scientific article published on 3 June 2015

Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology

scientific article published on 28 January 2017

Usefulness of multi-detector row computed tomography for management of duodenal varices by emergency balloon-occluded retrograde transvenous obliteration

scientific article

Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases

scientific article published on 02 April 2013

Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers

scientific journal article

Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors

scientific article

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.

scientific article published on 11 April 2016

Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity

scientific article published on 30 January 2015

Wisteria floribunda agglutinin positive Mac-2-binding protein level increases in patients with acute liver injury

scientific article

Zoledronic acid delays disease progression of bone metastases from hepatocellular carcinoma

scientific article published on 7 October 2010

[A case of advanced hepatocellular carcinoma with lung, brain and lymph node metastases recurred 8 years after hepatectomy successfully treated by operation, radiation and systemic chemotherapy using S-1/CDDP]

scientific article published on 01 August 2012

[A case of clonorchiasis complicated with the expansion of liver cyst]

scientific article published on 01 March 2013

[A case report of hepatocellular carcinoma with metastases to the lip, stomach, and colorectum]

[Case of double cancer of the liver, cholangiocarcinoma and hepatocellular carcinoma detected in a patient with hepatitis C 13 years after diminution of HCV-RNA by interferon treatment]

scientific article published on 01 May 2009

[Practice of screening tests for a group of patients with a high risk of developing liver cancer]

scientific article published on 01 January 2008

[Q & A. Intra-hepatic multiple nodules developing following treatment of hepatic calculi].

scientific article published in December 2011

eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA

scientific article published on 22 October 2019

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