List of works by Gianpietro Dotti

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

scientific article published on 10 August 2018

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

scientific article published on 23 June 2005

Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes

scientific article published on 19 October 2011

Adoptive T-cell immunotherapy of chronic lymphocytic leukaemia

scientific article published on September 2008

Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience

scientific article

Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity

scientific article published on 12 September 2002

An inducible caspase 9 safety switch for T-cell therapy

scientific article published on 22 February 2005

An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies

scientific article published on June 2010

Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma

scientific article published on 23 July 2020

Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis

scientific article published on 12 October 2020

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

scientific article published on 7 October 2011

Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor

scientific article

Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity

scientific article

Bystander Transfer of Functional Human CD40 Ligand from Gene-Modified Fibroblasts to B-Chronic Lymphocytic Leukemia Cells ⬇️

scientific article published on April 10, 2003

CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma

scientific article published on 8 June 2017

CARs on track in the clinic

scientific article

CD19-CAR trials

scientific article published on March 2014

CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

scientific article

Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease

scientific article

Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes

scientific article published on 14 August 2017

Clinical responses with T lymphocytes targeting malignancy-associated κ light chains

scientific article published on 06 June 2016

Clonal Dynamics In Vivo of Virus Integration Sites of T Cells Expressing a Safety Switch

scientific article

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

scientific article

Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.

scientific article

Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia

scientific article published on 12 July 2011

Cryo-shocked cancer cells for targeted drug delivery and vaccination

scientific article published on 09 December 2020

Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia

scientific article

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

scientific article

Design and development of therapies using chimeric antigen receptor-expressing T cells

scientific article published on January 2014

Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis

scientific article published on 13 May 2021

Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application

scientific article

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

scientific article published on 23 September 2020

Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

scientific article

Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ(null) mice.

scientific article

Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma

scientific article published on 06 October 2021

Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?".

scientific article

Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment

scientific article

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

scientific article published on 14 May 2009

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade

scientific article published on 29 March 2016

Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

scientific article published on 16 September 2009

Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.

scientific article published on 3 March 2009

HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial

scientific article published on 20 April 2017

High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells

scientific article

Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

scientific article published on 23 March 2015

Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.

scientific article published on 15 February 2005

Immunotherapy of human cancers using gene modified T lymphocytes

scientific article

Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells

scientific article published on 8 September 2009

In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas

scientific article published on 13 September 2018

Inducible apoptosis as a safety switch for adoptive cell therapy

scientific article (publication date: 3 November 2011)

Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation

scientific article published on 29 May 2007

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

scientific article published on 14 May 2015

Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes

scientific article

Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

scientific article published on 12 September 2013

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

scientific article published on 26 April 2021

Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma

scientific article published on 13 November 2012

Interleukin-23 engineering improves CAR T cell function in solid tumors

scientific article published on 03 February 2020

Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes (CTLs) without enhancement of regulatory T-cell inhibition

scientific article published on 4 October 2013

Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene

scientific article

Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers.

scientific article published on 18 June 2015

Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes

scientific article published on 9 November 2004

Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells

scientific article published on August 2009

Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

scientific article published on 3 July 2003

Regression of experimental medulloblastoma following transfer of HER2-specific T cells

scientific article published in June 2007

Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU

scientific article

Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia

scientific article published on October 2005

Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease

scientific article published on 14 December 2012

Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression

scientific article published on 18 November 2009

Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation

scientific article published on 28 December 2015

Survivin-specific T cell receptor targets tumor but not T cells

scientific article

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.

scientific article published on 17 April 2009

T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells

scientific article published on 22 August 2006

T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor-Expressing T Cells

scientific article published on 26 September 2019

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

scientific article published on 18 July 2016

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

scientific article published on 02 July 2019

Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration

scientific article published on 20 April 2022

Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40(+) and CD40(-) plasmacytoma cells

scientific article

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

scientific article published on 4 May 2015

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

scientific article published on 15 July 2020

Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma

scientific article published on 9 January 2018

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