List of works - Helga E de Vries

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence

scientific article

Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?

scientific article published on 13 September 2008

Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

scientific article published on June 2010

The blood-brain barrier and its role in immune privilege in the central nervous system

scientific article

Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy.

scientific article published on 23 March 2011

Radical changes in multiple sclerosis pathogenesis

scientific article published on 27 June 2010

Enhanced number and activity of mitochondria in multiple sclerosis lesions

scientific article published in October 2009

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

scientific article published on 06 March 2014

The blood-brain barrier in cortical multiple sclerosis lesions

scientific article

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

scientific article published on 21 May 2012

Retinoic acid induces blood-brain barrier development.

scientific article published on January 2013

Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

scientific article

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

scientific article

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

scientific article

Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium

scientific journal article

Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity

scientific article

Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology

scientific article

Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption.

scientific article published in September 2003

Extensive extracellular matrix depositions in active multiple sclerosis lesions

scientific article published on 26 September 2006

Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions

scientific article (publication date: May 2003)

Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

scientific article published on 19 July 2012

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)

scientific article

Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions

scientific article published on July 29, 2010

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

scientific article

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease

scientific article

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation

scientific article published on June 23, 2012

SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

scientific article

Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes

scientific article published on 01 August 2005

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types

scientific article published on May 26, 2011

Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy.

scientific article published in February 2012

The extracellular matrix in multiple sclerosis pathology

scientific article published on 13 September 2007

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis

scientific article

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

scientific article

Functions of lipid raft membrane microdomains at the blood-brain barrier

scientific article published on 30 May 2009

Grey matter damage in multiple sclerosis: a pathology perspective

scientific article

Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases

scientific article

GM-CSF promotes migration of human monocytes across the blood brain barrier.

scientific article

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

scientific article

P-glycoprotein acts as an immunomodulator during neuroinflammation.

scientific article

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

scientific article published on 09 June 2012

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

scientific article

Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies

scientific article

Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier

scientific article

NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions

scientific article published on 26 April 2006

The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.

scientific article

Neuronal and axonal loss in normal-appearing gray matter and subpial lesions in multiple sclerosis

scientific article

MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent

scientific article published on August 2013

Molecular alterations of the blood-brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition

scientific article

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.

scientific article published on 3 August 2015

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

scientific article

List of works by Helga E de Vries

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence

Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?

Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

The blood-brain barrier and its role in immune privilege in the central nervous system

Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy.

Radical changes in multiple sclerosis pathogenesis

Enhanced number and activity of mitochondria in multiple sclerosis lesions

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

The blood-brain barrier in cortical multiple sclerosis lesions

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

Retinoic acid induces blood-brain barrier development.

Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium

Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity

Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology

Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption.

Extensive extracellular matrix depositions in active multiple sclerosis lesions

Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions

Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)

Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation

SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types

Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy.

The extracellular matrix in multiple sclerosis pathology

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

Functions of lipid raft membrane microdomains at the blood-brain barrier

Grey matter damage in multiple sclerosis: a pathology perspective

Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases

GM-CSF promotes migration of human monocytes across the blood brain barrier.

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

P-glycoprotein acts as an immunomodulator during neuroinflammation.

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies

Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier

NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions

The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.

Neuronal and axonal loss in normal-appearing gray matter and subpial lesions in multiple sclerosis

MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent

Molecular alterations of the blood-brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients