List of works - Helga E de Vries

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

scientific article published on 27 October 2017

Activation of endogenous neural stem cells for multiple sclerosis therapy

scientific article

Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood-brain barrier dysfunction and seizure progression

scientific article published on 08 September 2018

Alterations of Gut Microbiota and the Brain-Immune-Intestine Axis in Patients With Relapsing-Remitting Multiple Sclerosis After Treatment With Oral Cladribine: Protocol for a Prospective Observational Study

scientific article published on 29 July 2020

Altered blood-brain barrier transport in neuro-inflammatory disorders

scientific article published on June 2016

Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy.

scientific article published on 23 March 2011

Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases

scientific article

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis

scientific article

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

scientific article

Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes

scientific article published on 01 August 2005

Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

scientific article

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms.

scientific article published on 22 December 2015

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

scientific article

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types ⬇️

scientific article published on May 26, 2011

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

scientific article

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions

scientific article

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

scientific article

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

scientific article

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation ⬇️

scientific article published on June 23, 2012

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.

scientific article published on 3 August 2015

Enhanced number and activity of mitochondria in multiple sclerosis lesions

scientific article published in October 2009

Extensive extracellular matrix depositions in active multiple sclerosis lesions

scientific article published on 26 September 2006

Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

scientific article published on 19 July 2012

Functions of lipid raft membrane microdomains at the blood-brain barrier

scientific article published on 30 May 2009

GM-CSF promotes migration of human monocytes across the blood brain barrier.

scientific article

Grey matter damage in multiple sclerosis: a pathology perspective

scientific article

Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies

scientific article

In Vitro and Ex Vivo Model Systems to Measure ABC Transporter Activity at the Blood-Brain Barrier

scientific article

Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells

scientific article published on 03 February 2020

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease

scientific article

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

scientific article

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

scientific article published on 21 May 2012

Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption.

scientific article published in September 2003

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

scientific article published on 09 June 2012

Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity

scientific article

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

scientific article published on 31 July 2019

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

scientific article

Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions

scientific article (publication date: May 2003)

Mesenchymal stem cells are mobilized from the bone marrow during inflammation

scientific article published on 4 March 2013

MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium

scientific article published on 30 March 2017

MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro

scientific article

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

scientific article published on 06 March 2014

Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

scientific article published on 17 November 2020

Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

scientific article published on June 2010

Modeling ischemic stroke in a triculture neurovascular unit on-a-chip

scientific article published on 14 December 2021

Molecular alterations of the blood-brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition

scientific article

Morphogens and blood-brain barrier function in health and disease

scientific article published on 11 September 2015

Mycobacteria employ two different mechanisms to cross the blood-brain barrier

scientific article published on 30 May 2018

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

scientific article published on 26 April 2021

NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions

scientific article published on 26 April 2006

Nanoclusters of iron oxide: effect of core composition on structure, biocompatibility, and cell labeling efficacy

scientific article

Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy.

scientific article published in February 2012

Neuronal and axonal loss in normal-appearing gray matter and subpial lesions in multiple sclerosis

scientific article

Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions ⬇️

scientific article published on July 29, 2010

Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?

scientific article published on 13 September 2008

P-glycoprotein acts as an immunomodulator during neuroinflammation.

scientific article

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)

scientific article

Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

scientific article published on 01 June 2021

Protective effects of monomethyl fumarate at the inflamed blood-brain barrier

scientific article published on 8 December 2015

Protective effects of peroxiredoxin-1 at the injured blood-brain barrier

scientific article

Radical changes in multiple sclerosis pathogenesis

scientific article published on 27 June 2010

Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock.

scientific article published on 23 February 2016

Retinoic acid induces blood-brain barrier development.

scientific article published on January 2013

SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

scientific article

Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium

scientific journal article

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

scientific article published on 10 May 2022

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling.

scientific article published on 27 March 2015

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

scientific article published on 28 November 2019

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

scientific article

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

scientific article

Surgery-induced reactive oxygen species enhance colon carcinoma cell binding by disrupting the liver endothelial cell lining ⬇️

scientific article published on January 27, 2011

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence

scientific article

The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids

scientific article published on 30 April 2012

The best basic science paper in multiple sclerosis in 2014: important role for the choroid plexus in the central nervous system entry of leukocytes

scientific article published on 25 February 2015

The blood-brain barrier and its role in immune privilege in the central nervous system

scientific article

The blood-brain barrier in cortical multiple sclerosis lesions

scientific article

The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.

scientific article

The extracellular matrix in multiple sclerosis pathology

scientific article published on 13 September 2007

Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology

scientific article

Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier

scientific article

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis

scientific article

Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

scientific article published on 30 April 2020

List of works by Helga E de Vries

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

Activation of endogenous neural stem cells for multiple sclerosis therapy

Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood-brain barrier dysfunction and seizure progression

Alterations of Gut Microbiota and the Brain-Immune-Intestine Axis in Patients With Relapsing-Remitting Multiple Sclerosis After Treatment With Oral Cladribine: Protocol for a Prospective Observational Study

Altered blood-brain barrier transport in neuro-inflammatory disorders

Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy.

Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases

Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes

Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms.

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types ⬇️

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation ⬇️

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.

Enhanced number and activity of mitochondria in multiple sclerosis lesions

Extensive extracellular matrix depositions in active multiple sclerosis lesions

Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

Functions of lipid raft membrane microdomains at the blood-brain barrier

GM-CSF promotes migration of human monocytes across the blood brain barrier.

Grey matter damage in multiple sclerosis: a pathology perspective

Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies

In Vitro and Ex Vivo Model Systems to Measure ABC Transporter Activity at the Blood-Brain Barrier

Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption.

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions

Mesenchymal stem cells are mobilized from the bone marrow during inflammation

MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium

MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

Modeling ischemic stroke in a triculture neurovascular unit on-a-chip

Molecular alterations of the blood-brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition

Morphogens and blood-brain barrier function in health and disease

Mycobacteria employ two different mechanisms to cross the blood-brain barrier

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses <i>In Vitro</i> Without Altering Inflammatory Disease Outcomes

NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions

Nanoclusters of iron oxide: effect of core composition on structure, biocompatibility, and cell labeling efficacy

Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy.

Neuronal and axonal loss in normal-appearing gray matter and subpial lesions in multiple sclerosis

Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions ⬇️

Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?

P-glycoprotein acts as an immunomodulator during neuroinflammation.

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)

Pro-resolving lipid mediator lipoxin A<sub>4</sub> attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

Protective effects of monomethyl fumarate at the inflamed blood-brain barrier

Protective effects of peroxiredoxin-1 at the injured blood-brain barrier

Radical changes in multiple sclerosis pathogenesis

Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock.

Retinoic acid induces blood-brain barrier development.

SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium

Single-cell profiling reveals periventricular CD56<sup>bright</sup> NK cell accumulation in multiple sclerosis

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling.

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

Surgery-induced reactive oxygen species enhance colon carcinoma cell binding by disrupting the liver endothelial cell lining ⬇️

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence

The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids

The best basic science paper in multiple sclerosis in 2014: important role for the choroid plexus in the central nervous system entry of leukocytes

The blood-brain barrier and its role in immune privilege in the central nervous system

The blood-brain barrier in cortical multiple sclerosis lesions

The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.

The extracellular matrix in multiple sclerosis pathology

Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology