List of works by Taosheng Chen

A high-content screen identifies inhibitors of nuclear export of forkhead transcription factors.

scientific article

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

scientific article published on 21 April 2020

A phosphotyrosine switch regulates organic cation transporters ⬇️

scientific article published on 16 March 2016

An automated approach to efficiently reformat a large collection of compounds.

scientific article

BRAF inhibition protects against hearing loss in mice

scientific article published on 02 December 2020

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

scientific article

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

scientific article published on 10 July 2020

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

scientific article published on 22 January 2020

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay

scientific article published on 18 October 2020

Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria

scientific article published on 13 January 2020

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

scientific article published on 4 November 2017

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

scientific article published on 01 October 2020

KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion

scientific article published on 30 January 2020

MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

scientific article published on 20 October 2020

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

scientific article published on 01 April 2022

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

scientific article

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

scientific article published on 30 March 2020

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

scientific article published on 02 July 2021

Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer

scientific article published on 28 November 2019

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

scientific article published on 01 October 2020

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

scientific article published on 6 July 2017

Targeting OCT3 attenuates doxorubicin-induced cardiac injury

scientific article published in 2021

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

scientific article published on 09 November 2021

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

scientific article

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

scientific article published on 28 June 2019

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