List of works - Sang Dal Rhee

A novel 11β-HSD1 inhibitor improves diabesity and osteoblast differentiation.

scientific article published on 6 March 2014

Amelioration of hypercholesterolemia by an EGFR tyrosine kinase inhibitor in mice with liver-specific knockout of Mig-6.

scientific article

Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor in the diet-induced obese mice

scientific article published on July 2012

Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344).

scientific article

Anti-diabetic and anti-inflammatory effect of a novel selective 11β-HSD1 inhibitor in the diet-induced obese mice

scientific article published on 14 October 2013

Anti-inflammatory effect of a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages

scientific article published on 16 July 2016

Anticancer effect of XAV939 is observed by inhibiting lactose dehydrogenase A in a 3-dimensional culture of colorectal cancer cells

scientific article published on 05 September 2019

Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis

scientific article

Cyp7a1 is continuously increased with disrupted Fxr-mediated feedback inhibition in hypercholesterolemic TALLYHO/Jng mice

scientific article published on 24 August 2017

Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists

scientific article

Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes

scientific article published on 27 June 2015

Discovery of cyclicsulfonamide derivatives as 11 beta-hydroxysteroid dehydrogenase 1 inhibitors

scientific article

Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors

scientific article published on 14 January 2011

Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes

scientific article published on 01 June 2018

Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6.

scientific article published on 07 December 2016

Fine localization of Nefl and Nef3 and its exclusion as candidate gene for lens rupture 2(lr2).

scientific article

Glucose intolerance in young TallyHo mice is induced by leptin-mediated inhibition of insulin secretion

scientific article published on 2 November 2005

Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts

scientific article published on 26 October 2015

Identification of cyclicsulfonamide derivatives with an acetamide group as 11β-hydroxysteroid dehydrogenase 1 inhibitors

scientific article published on 01 January 2011

Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice

scientific article

Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists

scientific article published on July 2006

Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold

scientific article published in July 2005

Inhibitory effect of leptin on rosiglitazone-induced differentiation of primary adipocytes prepared from TallyHO/Jng mice

scientific article published on 23 February 2011

KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity

scientific article

KR-62980: a novel peroxisome proliferator-activated receptor gamma agonist with weak adipogenic effects

scientific article published on 12 May 2006

Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells

scientific article published on 29 May 2017

Leptin inhibits rosiglitazone-induced adipogenesis in murine primary adipocytes

scientific article

Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

scientific article

PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives

scientific article

Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor

scientific article published on 13 January 2012

Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages.

scientific article published in August 2004

Protective effects of carbenoxolone, an 11β-HSD1 inhibitor, against chemical induced dry eye syndrome

scientific article published on 8 September 2017

Pyrazolidine derivatives with heteroaryl urea as dipeptidyl peptidase IV inhibitors

scientific article published in August 2005

Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.

scientific article published on 30 March 2010

Small intestine submucosa sponge for in vivo support of tissue-engineered bone formation in the presence of rat bone marrow stem cells

scientific journal article

Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group ⬇️

scientific article published on 02 November 2010

Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents

scientific article published in September 2004

Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.

scientific article published on 4 June 2013

Synthesis and biological evaluation of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors

scientific article

Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors

scientific article

Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors

scientific article

Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

scientific article published on 20 October 2017

Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists

scientific article

Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors

scientific article published in March 2005

Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists

scientific article published on 30 June 2007

Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors

scientific article

T-Cell Death Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγRXRα Heterodimer Formation in Adipogenesis

scientific article published on 18 December 2020

List of works by Sang Dal Rhee

A novel 11β-HSD1 inhibitor improves diabesity and osteoblast differentiation.

Amelioration of hypercholesterolemia by an EGFR tyrosine kinase inhibitor in mice with liver-specific knockout of Mig-6.

Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor in the diet-induced obese mice

Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344).

Anti-diabetic and anti-inflammatory effect of a novel selective 11β-HSD1 inhibitor in the diet-induced obese mice

Anti-inflammatory effect of a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages

Anticancer effect of XAV939 is observed by inhibiting lactose dehydrogenase A in a 3-dimensional culture of colorectal cancer cells

Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis

Cyp7a1 is continuously increased with disrupted Fxr-mediated feedback inhibition in hypercholesterolemic TALLYHO/Jng mice

Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists

Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes

Discovery of cyclicsulfonamide derivatives as 11 beta-hydroxysteroid dehydrogenase 1 inhibitors

Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors

Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes

Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6.

Fine localization of Nefl and Nef3 and its exclusion as candidate gene for lens rupture 2(lr2).

Glucose intolerance in young TallyHo mice is induced by leptin-mediated inhibition of insulin secretion

Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts

Identification of cyclicsulfonamide derivatives with an acetamide group as 11β-hydroxysteroid dehydrogenase 1 inhibitors

Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice

Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists

Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold

Inhibitory effect of leptin on rosiglitazone-induced differentiation of primary adipocytes prepared from TallyHO/Jng mice

KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity

KR-62980: a novel peroxisome proliferator-activated receptor gamma agonist with weak adipogenic effects

Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells

Leptin inhibits rosiglitazone-induced adipogenesis in murine primary adipocytes

Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives

Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor

Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages.

Protective effects of carbenoxolone, an 11β-HSD1 inhibitor, against chemical induced dry eye syndrome

Pyrazolidine derivatives with heteroaryl urea as dipeptidyl peptidase IV inhibitors

Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.

Small intestine submucosa sponge for in vivo support of tissue-engineered bone formation in the presence of rat bone marrow stem cells

Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group ⬇️

Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents

Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.

Synthesis and biological evaluation of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors

Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors

Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors

Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists

Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors

Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists

Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors

T-Cell Death Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγRXRα Heterodimer Formation in Adipogenesis