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List of works by Nikolaus Osterrieder

A DNA vaccine containing an infectious Marek's disease virus genome can confer protection against tumorigenic Marek's disease in chickens

scientific article published in October 2002

A Point Mutation in a Herpesvirus Co-Determines Neuropathogenicity and Viral Shedding

scientific article published on 10 January 2017

A deletion in the glycoprotein L (gL) gene of U.S. Marek's disease virus (MDV) field strains is insufficient to confer increased pathogenicity to the bacterial artificial chromosome (BAC)-based strain, RB-1B.

scientific article published on June 2013

A deletion within glycoprotein L of Marek's disease virus (MDV) field isolates correlates with a decrease in bivalent MDV vaccine efficacy in contact-exposed chickens

scientific article

A full UL13 open reading frame in Marek's disease virus (MDV) is dispensable for tumor formation and feather follicle tropism and cannot restore horizontal virus transmission of rRB-1B in vivo

scientific article published on 13 March 2007

A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.

scholarly article

A novel endogenous betaretrovirus group characterized from polar bears (Ursus maritimus) and giant pandas (Ailuropoda melanoleuca)

scientific article (publication date: 15 August 2013)

A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America.

scientific article published on 3 September 2017

A point mutation in a herpesvirus polymerase determines neuropathogenicity

scientific article

A potentially fatal mix of herpes in zoos

scientific article

A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9.

scientific article

A severe equine herpesvirus type 1 (EHV-1) abortion outbreak caused by a neuropathogenic strain at a breeding farm in northern Germany.

scientific article published on 2 July 2014

A single-nucleotide polymorphism in a herpesvirus DNA polymerase is sufficient to cause lethal neurological disease

scientific article

A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virus

scientific article published on 06 November 2009

A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis.

scientific article

Alphaherpesviruses and chemokines: pas de deux not yet brought to perfection.

scientific article published on 02 April 2008

An equine herpesvirus 1 (EHV-1) vectored H1 vaccine protects against challenge with swine-origin influenza virus H1N1.

scientific article

An equine herpesvirus type 1 (EHV-1) expressing VP2 and VP5 of serotype 8 bluetongue virus (BTV-8) induces protection in a murine infection model

scientific article

An equine herpesvirus type 1 (EHV-1) vector expressing Rift Valley fever virus (RVFV) Gn and Gc induces neutralizing antibodies in sheep

scientific article published on 14 August 2017

Analysis of the herpesvirus chemokine-binding glycoprotein G residues essential for chemokine binding and biological activity

scientific article published on 12 December 2008

Attenuation of Marek's disease virus by deletion of open reading frame RLORF4 but not RLORF5a

scientific article

Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization.

scientific article published on 29 January 2018

Bats, Primates, and the Evolutionary Origins and Diversification of Mammalian Gammaherpesviruses

scientific article

Binding of alphaherpesvirus glycoprotein H to surface α4β1-integrins activates calcium-signaling pathways and induces phosphatidylserine exposure on the plasma membrane.

scientific article published on 20 October 2015

CCL3 and viral chemokine-binding protein gg modulate pulmonary inflammation and virus replication during equine herpesvirus 1 infection

scientific article

Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species

scientific article

Characterization of Marek's disease virus serotype 1 (MDV-1) deletion mutants that lack UL46 to UL49 genes: MDV-1 UL49, encoding VP22, is indispensable for virus growth

scientific article

Clinical observations and management of a severe equine herpesvirus type 1 outbreak with abortion and encephalomyelitis.

scientific article published on 5 March 2013

Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strain

scientific article published on 31 May 2008

Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias

scientific article published on 23 December 2015

Comparative analysis of glycoprotein B (gB) of equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) in cellular tropism and cell-to-cell transmission

scientific article

Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1).

scientific article

Comparison of two trapping methods for Culicoides biting midges and determination of African horse sickness virus prevalence in midge populations at Onderstepoort, South Africa

scientific article published in October 2011

Complete genome sequence of virulent duck enteritis virus (DEV) strain 2085 and comparison with genome sequences of virulent and attenuated DEV strains

scientific article published on 23 July 2011

Comprehensive Serology Based on a Peptide ELISA to Assess the Prevalence of Closely Related Equine Herpesviruses in Zoo and Wild Animals

scientific article

Construction and manipulation of a full-length infectious bacterial artificial chromosome clone of equine herpesvirus type 3 (EHV-3).

scientific article published on 16 November 2016

Contribution of gene products encoded within the unique short segment of equine herpesvirus 1 to virulence in a murine model

scientific article published on December 2002

Cowpox virus serpin CrmA is necessary but not sufficient for the red pock phenotype on chicken chorioallantoic membranes

scientific article published on 12 October 2011

Cytokine profiles and long-term virus-specific antibodies following immunization of CBA mice with equine herpesvirus 1 and viral glycoprotein D.

scientific article published in January 2003

Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity

article

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

scientific article

Detection of Marek's disease virus DNA in chicken but not in human plasma

scientific article

Development of a peptide ELISA for discrimination between serological responses to equine herpesvirus type 1 and 4.

scientific article published on 5 August 2013

Dietary Enterococcus faecium NCIMB 10415 and zinc oxide stimulate immune reactions to trivalent influenza vaccination in pigs but do not affect virological response upon challenge infection

scientific article (publication date: 2014)

Down-regulation of MHC class I by the Marek's disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion.

scientific article published on 15 July 2010

Effective treatment of respiratory alphaherpesvirus infection using RNA interference.

scientific article

En passant mutagenesis: a two step markerless red recombination system.

scientific article published in January 2010

Enzymatically inactive U(S)3 protein kinase of Marek's disease virus (MDV) is capable of depolymerizing F-actin but results in accumulation of virions in perinuclear invaginations and reduced virus growth

scientific article published on 4 March 2008

Equid herpesvirus 1 (EHV1) infection of equine mesenchymal stem cells induces a pUL56-dependent downregulation of select cell surface markers

scientific article

Equid herpesvirus type 1 activates platelets

scientific article published on 23 April 2015

Equid herpesvirus type 4 uses a restricted set of equine major histocompatibility complex class I proteins as entry receptors.

scientific article published on 10 April 2014

Equine Herpesvirus 1 Multiply Inserted Transmembrane Protein pUL43 Cooperates with pUL56 in Downregulation of Cell Surface Major Histocompatibility Complex Class I.

scientific article published on April 2015

Equine herpesvirus 1 entry via endocytosis is facilitated by alphaV integrins and an RSD motif in glycoprotein D.

scientific article published on 24 September 2008

Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.

scientific article

Equine herpesvirus type 1 (EHV-1) glycoprotein K is required for efficient cell-to-cell spread and virus egress

scientific article

Equine herpesvirus type 1 (EHV-1) open reading frame 59 encodes an early protein that is localized to the cytosol and required for efficient virus growth

scientific article published on 14 December 2013

Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells

scientific article

Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells

scientific article

Equine herpesvirus type 1 devoid of gM and gp2 is severely impaired in virus egress but not direct cell-to-cell spread

scientific article

Equine herpesvirus type 1 infection induces procoagulant activity in equine monocytes

scientific article published on 11 March 2013

Equine herpesvirus type 1 modified live virus vaccines: quo vaditis?

scientific article

Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells.

scientific article published on 19 July 2014

Equine herpesvirus type 4 UL56 and UL49.5 proteins downregulate cell surface major histocompatibility complex class I expression independently of each other

scientific article published on 23 May 2012

Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression

scientific article

Equine herpesviruses type 1 (EHV-1) and 4 (EHV-4)--masters of co-evolution and a constant threat to equids and beyond

scientific article published on 06 July 2013

Evaluation of a vectored equine herpesvirus type 1 (EHV-1) vaccine expressing H3 haemagglutinin in the protection of dogs against canine influenza

scientific article published on 31 March 2008

Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant

scientific article

Evaluation of metaphylactic RNA interference to prevent equine herpesvirus type 1 infection in experimental herpesvirus myeloencephalopathy in horses

scientific article published on 01 February 2013

Evaluation of the vaccine potential of an equine herpesvirus type 1 vector expressing bovine viral diarrhea virus structural proteins

scientific article published in March 2007

Experimental Cowpox Virus (CPXV) Infections of Bank Voles: Exceptional Clinical Resistance and Variable Reservoir Competence

scientific article published on 19 December 2017

Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1) completely restores respiratory virulence to the attenuated EHV-1 strain KyA in CBA mice

scientific article

Fluorescently tagged pUL47 of Marek's disease virus reveals differential tissue expression of the tegument protein in vivo

scientific article published on 21 December 2011

Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential.

scientific article

Generation and characterization of an EICP0 null mutant of equine herpesvirus 1.

scientific article published in December 2003

Generation of a complete single-gene knockout bacterial artificial chromosome library of cowpox virus and identification of its essential genes

scientific article (publication date: 2014)

Generation of a permanent cell line that supports efficient growth of Marek's disease virus (MDV) by constitutive expression of MDV glycoprotein E.

scientific article published on August 2002

Generation of an infectious clone of duck enteritis virus (DEV) and of a vectored DEV expressing hemagglutinin of H5N1 avian influenza virus

scientific article published on 28 April 2011

Glycoprotein B of equine herpesvirus type 1 has two recognition sites for subtilisin-like proteases that are cleaved by furin

scientific article published on 3 February 2016

Glycoprotein H and α4β1 integrins determine the entry pathway of alphaherpesviruses

scientific article published on 20 March 2013

Glycoproteins D of Equine Herpesvirus Type 1 (EHV-1) and EHV-4 Determine Cellular Tropism Independently of Integrins ⬇️

scientific article published on December 14, 2011

Herpesvirus Genome Integration into Telomeric Repeats of Host Cell Chromosomes.

scientific article published on 27 June 2014

Herpesvirus Telomerase RNA(vTR)-Dependent Lymphoma Formation Does Not Require Interaction of vTR with Telomerase Reverse Transcriptase (TERT) ⬇️

scientific article published on August 26, 2010

Herpesvirus chemokine-binding glycoprotein G (gG) efficiently inhibits neutrophil chemotaxis in vitro and in vivo

scientific article published on September 2007

Herpesvirus telomerase RNA (vTR) with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis.

scientific article

Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation ⬇️

scientific article published on March 7, 2011

Herpesviruses--a zoonotic threat?

scientific article

High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in piglets

scientific article

High-level expression of Marek's disease virus glycoprotein C is detrimental to virus growth in vitro

scientific article

Horizontal transmission of Marek's disease virus requires US2, the UL13 protein kinase, and gC

scientific article

Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I.

scientific article published on 25 January 2012

Impact of ETIF deletion on safety and immunogenicity of equine herpesvirus type 1-vectored vaccines

scientific article

In vitro and in vivo characterization of equine herpesvirus type 1 (EHV-1) mutants devoid of the viral chemokine-binding glycoprotein G (gG).

scientific article published on 23 January 2007

In vitro model for lytic replication, latency, and transformation of an oncogenic alphaherpesvirus.

scientific article published on 26 May 2015

Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strain

scientific article published on 28 June 2011

Intrahost evolutionary dynamics of canine influenza virus in naive and partially immune dogs

scientific article

Investigation of the prevalence of neurologic equine herpes virus type 1 (EHV-1) in a 23-year retrospective analysis (1984-2007).

scientific article published on 26 June 2009

Live-attenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV).

scientific article published on 22 January 2007

Long term stability and infectivity of herpesviruses in water

scientific article

Major histocompatibility complex class I downregulation induced by equine herpesvirus type 1 pUL56 is through dynamin-dependent endocytosis

scientific article

Marek's disease viral interleukin-8 promotes lymphoma formation through targeted recruitment of B cells and CD4+ CD25+ T cells

scientific article published on 30 May 2012

Marek's disease virus expresses multiple UL44 (gC) variants through mRNA splicing that are all required for efficient horizontal transmission

scientific article

Marek's disease virus: from miasma to model

scientific article

Marek's disease virus: lytic replication, oncogenesis and control.

scientific article published on December 2006

Marek’s disease virus (MDV) ubiquitin-specific protease (USP) performs critical functions beyond its enzymatic activity during virus replication ⬇️

scientific article published on February 9, 2013

Meningoencephalitis in mice infected with an equine herpesvirus 1 strain KyA recombinant expressing glycoprotein I and glycoprotein E.

scientific article

Molecular characterization of the equine herpesvirus 1 strains RacL11 and Kentucky D.

scientific article published in May 2007

Mutagenesis of a bovine herpesvirus type 1 genome cloned as an infectious bacterial artificial chromosome: analysis of glycoprotein E and G double deletion mutants

scientific article published on February 2003

Oncogenicity of virulent Marek's disease virus cloned as bacterial artificial chromosomes.

scientific article published on December 2004

Out of the Reservoir: Phenotypic and Genotypic Characterization of a Novel Cowpox Virus Isolated from a Common Vole

scientific article

Pathogenic potential of equine alphaherpesviruses: the importance of the mononuclear cell compartment in disease outcome

scientific article

Peptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses

scientific article

Phocine herpesvirus 1 (PhHV-1) in harbor seals from Svalbard, Norway

scientific article published on 21 March 2013

Potential of equine herpesvirus 1 as a vector for immunization

scientific article

Prevalence of equine gammaherpesviruses on breeding farms in Turkey and development of a TaqMan MGB real-time PCR to detect equine herpesvirus 5 (EHV-5).

scientific article published on 10 July 2014

Prevention of equine herpesvirus myeloencephalopathy - Is heparin a novel option? A case report.

scientific article published on 21 September 2016

Properties of an equine herpesvirus 1 mutant devoid of the internal inverted repeat sequence of the genomic short region

scientific article

Protection of mice by equine herpesvirus type 1 based experimental vaccine against lethal Venezuelan equine encephalitis virus infection in the absence of neutralizing antibodies.

scientific article published in January 2008

Recombinant equine herpesvirus 1 (EHV-1) vaccine protects pigs against challenge with influenza A(H1N1)pmd09.

scientific article

Recovery of infectious virus from full-length cowpox virus (CPXV) DNA cloned as a bacterial artificial chromosome (BAC).

scientific article published on 11 January 2011

Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccines.

scientific article published on August 2003

Residue 752 in DNA polymerase of equine herpesvirus type 1 is non-essential for virus growth in vitro

scientific article published on 3 March 2010

Role of gB and pUS3 in Equine Herpesvirus 1 Transfer between Peripheral Blood Mononuclear Cells and Endothelial Cells: a Dynamic In Vitro Model

scientific article

Serological responses and clinical outcome after vaccination of mares and foals with equine herpesvirus type 1 and 4 (EHV-1 and EHV-4) vaccines

scientific article

Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture

scientific article

Strain impact on equine herpesvirus type 1 (EHV-1) abortion models: viral loads in fetal and placental tissues and foals.

scientific article published on 31 August 2012

Subclinical infection of a young captive Asian elephant with elephant endotheliotropic herpesvirus 1.

scientific article published in November 2017

The Marek's disease virus (MDV) protein encoded by the UL17 ortholog is essential for virus growth

scientific article published on 14 March 2009

The ORF012 gene of Marek's disease virus type 1 produces a spliced transcript and encodes a novel nuclear phosphoprotein essential for virus growth.

scientific article published on 12 November 2014

The alpha-TIF (VP16) homologue (ETIF) of equine herpesvirus 1 is essential for secondary envelopment and virus egress

scientific article published on March 2006

The common equine class I molecule Eqca-1*00101 (ELA-A3.1) is characterized by narrow peptide binding and T cell epitope repertoires

scientific article

The effect of siRNA treatment on experimental equine herpesvirus type 1 (EHV-1) infection in horses

scientific article published on 5 November 2009

The equine herpesvirus 1 UL34 gene product is involved in an early step in virus egress and can be efficiently replaced by a UL34-GFP fusion protein

scientific article

The gene 10 (UL49.5) product of equine herpesvirus 1 is necessary and sufficient for functional processing of glycoprotein M.

scientific article published on March 2002

The herpesvirus stealth program

scientific article published on 26 August 2015

The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virions

scientific article

The products of the UL10 (gM) and the UL49.5 genes of Marek's disease virus serotype 1 are essential for virus growth in cultured cells

scientific article published on May 2002

The protein encoded by the US3 orthologue of Marek's disease virus is required for efficient de-envelopment of perinuclear virions and involved in actin stress fiber breakdown

scientific article

The role of glycoprotein H of equine herpesviruses 1 and 4 (EHV-1 and EHV-4) in cellular host range and integrin binding

scientific article published on 21 August 2012

The role of secreted glycoprotein G of equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) in immune modulation and virulence

scientific article published on 8 August 2012

The truncated form of glycoprotein gp2 of equine herpesvirus 1 (EHV-1) vaccine strain KyA is not functionally equivalent to full-length gp2 encoded by EHV-1 wild-type strain RacL11

scientific article published on March 2004

The varicella-zoster virus ORFS/L (ORF0) gene is required for efficient viral replication and contains an element involved in DNA cleavage.

scientific article published on 15 September 2010

Three-dimensional normal human neural progenitor tissue-like assemblies: a model of persistent varicella-zoster virus infection

scientific article

Transgene expression in the genome of Middle East respiratory syndrome coronavirus based on a novel reverse genetics system utilizing Red-mediated recombination cloning

scientific article published on 6 October 2017

Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli

scientific article published in February 2006

Ubiquitination and degradation of the ORF34 gene product of equine herpesvirus type 1 (EHV-1) at late times of infection

scientific article published on 29 May 2014

Use of real-time quantitative reverse transcription polymerase chain reaction for the detection of African horse sickness virus replication in Culicoides imicola

scientific article published on 11 November 2011

Varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cells.

scientific article published on 21 May 2008

Varicella-zoster virus-induced apoptosis in MeWo cells is accompanied by down-regulation of Bcl-2 expression

scientific article published in March 2010

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.

scientific article

Viral control of vTR expression is critical for efficient formation and dissemination of lymphoma induced by Marek's disease virus (MDV).

scientific article

Viral genes and cellular markers associated with neurological complications during herpesvirus infections.

scientific article published on 20 June 2017

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

scientific article

West nile virus antibody prevalence in horses of Ukraine

scientific article published on 04 October 2013

Zebra Alphaherpesviruses (EHV-1 and EHV-9): Genetic Diversity, Latency and Co-Infections

scientific article published on 20 September 2016

Zebra-borne equine herpesvirus type 1 (EHV-1) infection in non-African captive mammals

scientific article published on 25 December 2013

[Establishment and use of infectious bacterial artificial chromosome (BAC) DNA clones of animal herpesviruses].

scientific article published in September 2003

vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus

scientific article

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