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List of works by Jürgen Borlak

A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice

scientific article

A Decade of Toxicogenomic Research and Its Contribution to Toxicological Science ⬇️

scientific article published on July 12, 2012

A Model to predict severity of drug-induced liver injury in humans

scientific article published on 15 June 2016

A discriminative approach for unsupervised clustering of DNA sequence motifs

scientific article

A new paradigm in toxicology and teratology: altering gene activity in the absence of DNA sequence variation

scientific article published on 22 May 2007

A novel computational approach for the prediction of networked transcription factors of aryl hydrocarbon-receptor-regulated genes.

scientific article

A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol

scientific article (publication date: November 2003)

A safety and tolerability study of differently-charged nanoparticles for local pulmonary drug delivery

scientific article published on 24 April 2010

A simple and reliable protocol for mouse serum proteome profiling studies by use of two-dimensional electrophoresis and MALDI TOF/TOF mass spectrometry

scientific article published on 12 September 2008

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

scientific article published on 11 June 2014

A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis

scientific article

A unifying ontology to integrate histological and clinical observations for drug-induced liver injury

scientific article published on 08 February 2013

Adipocyte-derived angiopoietin-1 supports neurite outgrowth and synaptogenesis of sensory neurons

scientific article published on May 2006

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

scientific article published on 18 January 2007

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac

scientific article published on 05 May 2020

An optimized method for the isolation and identification of membrane proteins

scientific article

An update on the mouse liver proteome

scientific article published on 8 September 2009

Androgen metabolism in thymus of fetal and adult rats

scientific article

Antibody conjugated PLGA nanoparticles for targeted delivery of paclitaxel palmitate: efficacy and biofate in a lung cancer mouse model

scientific article published on 21 July 2013

ApoE is a major determinant of hepatic bile acid homeostasis in mice

scientific article published on 28 September 2017

Application of restricted access material (RAM) with precolumn-switching and matrix solid-phase dispersion (MSPD) to the study of the metabolism and pharmacokinetics of Verapamil

scientific article published on 19 November 2002

Aroclor 1254 modulates gene expression of nuclear transcription factors: implications for albumin gene transcription and protein synthesis in rat hepatocyte cultures

scientific journal article

Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury

scientific article published on 22 June 2017

Automated in-tube solid-phase microextraction coupled with HPLC for the determination of N-nitrosamines in cell cultures

scientific article published in April 2002

Bridging the gap between anatomy and molecular genetics for an improved understanding of congenital heart disease

scientific article

Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.

scientific article

Cancer genomics predicts disease relapse and therapeutic response to neoadjuvant chemotherapy of hormone sensitive breast cancers

scientific article published on 18 May 2020

Clinical versatility of porcine hepatocytes in the light of interspecies differences in cytochrome P450 regulation and expression

scientific article published in July 2008

Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.

scientific article

Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies

scientific article

Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection

scientific article published on 17 September 2004

Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration

scientific article

Correction: Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma

Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation

scientific article

DNA adducts in cultures of polychlorinated biphenyl-treated human hepatocytes ⬇️

scientific article published on April 15, 2003

Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis

scientific article

Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas

scientific article published on 2 October 2015

Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures.

scientific article

Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes

scientific article published on 13 September 2007

Dihydrotestosterone—a culprit in left ventricular hypertrophy ⬇️

scientific article published on January 20, 2012

Disease-associated changes in the expression of ion channels, ion receptors, ion exchangers and Ca(2+)-handling proteins in heart hypertrophy

scientific article

Drug-Induced Liver Injury.

scientific article published on 9 January 2017

Drug-induced liver injury: Interactions between drug properties and host factors

scientific article published on 22 April 2015

Drug-induced phospholipidosis

scientific article

EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.

scientific article

Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence

scientific article

Epidermal growth factor-induced hepatocellular carcinoma: gene expression profiles in precursor lesions, early stage and solitary tumours

scientific article published on 01 March 2005

Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles

scientific article published on 12 November 2015

Explanted diseased livers - a possible source of metabolic competent primary human hepatocytes

scientific article

Expression of HNF4alpha in the human and rat choroid plexus: implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier

scientific article

Expression of a cyclin E1 isoform in mice is correlated with the quiescent cell cycle status of hepatocytes in vivo.

scientific article

Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers

scientific article

Gender-incompatible liver transplantation is not a risk factor for patient survival

scientific article published on 29 July 2008

Gene expression profiling of calcium-channel antagonists in the heart of hypertensive and normotensive rats reveals class specific effects

scientific article published on 6 September 2016

Genome wide prediction of HNF4alpha functional binding sites by the use of local and global sequence context

scientific article

Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis

scientific article published on 16 June 2016

Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease

article

Graft rejection: pharmacogenetic analysis or drug anamnesis?

scientific article published on 13 March 2008

Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line.

scientific article published on December 2003

HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy

scientific article published on 9 January 2008

HNF4alpha Dysfunction as a Molecular Rational for Cyclosporine Induced Hypertension ⬇️

scientific article published on January 27, 2011

HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus

scientific article

Hallmarks of ion channel gene expression in end-stage heart failure

scientific article

Hepatobiliary Events in Migraine Therapy with Herbs-The Case of Petadolex, A Petasites Hybridus Extract

scientific article published on 10 May 2019

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury ⬇️

scientific article published on May 27, 2013

How useful are clinical liver function tests in in vitro human hepatotoxicity assays?

scientific article published on 28 March 2014

Identification of major CYP2C9 and CYP2C19 polymorphisms by fluorescence resonance energy transfer analysis

scientific article published on 01 September 2002

Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcγ receptors.

scientific article published on 04 April 2016

Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice

scientific article published on 25 February 2016

Improved method for proteome mapping of the liver by 2-DE MALDI-TOF MS.

scientific article

Improving the diagnosis and management of neuroendocrine tumors: utilizing new advances in biomarker and molecular imaging science

scientific article published on 28 June 2013

In vitro to in vivo extrapolation for drug-induced liver injury using a pair ranking method

scientific article published on 11 January 2017

Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper

scientific article

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

scientific article published on 19 March 2016

Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.

scientific article

Isolation and cultivation of metabolically competent alveolar epithelial cells from A/J mice

scientific article published on 27 March 2014

LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium

scientific article

Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1-Mediated Autophagy in Human Granulosa Cells as an Alternative of Programmed Cell Death

article by Nicole Duerrschmidt et al published August 2006 in Endocrinology

Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression

scientific article

Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulatio

scientific article published on June 2004

Mapping of the serum proteome of hepatocellular carcinoma induced by targeted overexpression of epidermal growth factor to liver cells of transgenic mice

scientific article published on 17 January 2008

Matrix layer sample preparation: an improved MALDI-MS peptide analysis method for proteomic studies

scientific article

Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease

scientific article published on 8 July 2010

Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?

scientific article

Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades

scientific article published on 5 April 2016

Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.

scientific article

Metabolism of verapamil in cultures of rat alveolar epithelial cells and pharmacokinetics after administration by intravenous and inhalation routes

scientific article published on 10 May 2005

Method for the Rapid Detection and Molecular Characterization of DNA Alkylating Agents by MALDI-TOF Mass Spectrometry ⬇️

scientific article published on October 15, 2010

Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1.

scientific article

Molecular characterization of lung dysplasia induced by c-Raf-1.

scientific article

Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis

scientific article published on September 2008

Multidimensional on-line sample preparation of verapamil and its metabolites by a molecularly imprinted polymer coupled to liquid chromatography-mass spectrometry

scientific article published in March 2004

N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II.

scientific article published on June 2006

N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury

scientific article published on 7 August 2017

Nifedipine represses ion channels, transporters and Ca(2+)-binding proteins in hearts of spontaneously hypertensive rats

scientific journal article

No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy

scientific article

Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury

scientific article published on 11 January 2008

Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma

scientific article published on 23 October 2017

Pathology of flupirtine-induced liver injury: a histological and clinical study of six cases

scientific article published on 18 May 2011

Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice

scientific article published on 01 February 2011

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.

scientific article published on 28 January 2004

Physiological incompatibilities of porcine hepatocytes for clinical liver support

scientific article published in December 2006

Predicting idiosyncratic drug-induced liver injury: some recent advances

scientific article published on 23 May 2014

Primary non-function is frequently associated with fatty liver allografts and high mortality after re-transplantation.

scientific article

Primary rat alveolar epithelial cells for use in biotransformation and toxicity studies

scientific article published on 2 December 2005

Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events

scientific article

Quantitative mass spectrometry to investigate epidermal growth factor receptor phosphorylation dynamics

scientific article published on January 2008

Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs

scientific article published on 31 August 2013

RETRACTED: Toxicogenomics applied to in vitro toxicology: A cDNA- array based gene expression and protein activity study in human hepatocyte cultures upon treatment with Aroclor 1254

retracted scientific article published on 27 December 2005

RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain

scientific article

Recent advances in live cell imaging of hepatoma cells

scientific article

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

scientific article published on 06 March 2014

Regulation of Liver Enriched Transcription Factors in Rat Hepatocytes Cultures on Collagen and EHS Sarcoma Matrices

scientific article (publication date: 2015)

Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC.

scientific article published on 27 May 2016

Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury

scientific article

Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas

scientific article published on 28 June 2018

Serum proteomics of lung adenocarcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers

scientific article

Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element

scientific article published on November 2005

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b ⬇️

scientific article published on February 11, 2013

Synthesis and biological evaluation of epothilone A dimeric compounds.

scientific article published on 20 September 2009

Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20.

scientific article published on 7 October 2010

Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

scientific article published on 6 October 2009

Targeted Inactivation of HDAC2 Restores p16INK4a Activity and Exerts Antitumor Effects on Human Gastric Cancer ⬇️

scientific article published on November 21, 2012

Testosterone, cytochrome P450, and cardiac hypertrophy

scientific article published in October 2002

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

article

The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells

scientific article

The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression

scientific article published on 26 July 2006

The landscape of hepatobiliary adverse reactions across 53 herbal and dietary supplements reveals immune-mediated injury as a common cause of hepatitis

scientific article published on 13 November 2019

The myelin-associated glycoprotein inhibitor BENZ induces outgrowth and survival of rat dorsal root ganglion cell cultures

scientific article

The myosin ATPase inhibitor 2,3-butanedione monoxime dictates transcriptional activation of ion channels and Ca(2+)-handling proteins

scientific article

The pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury.

scientific article published on 23 September 2017

The risk of exaggerated risk aversion-a life and death struggle for molecular imaging

scientific article published on October 2009

Topoisomerase II inhibition involves characteristic chromosomal expression patterns

scientific article

Toward predictive models for drug-induced liver injury in humans: are we there yet?

scientific article published on January 2014

Towards a lung adenocarcinoma proteome map: studies with SP-C/c-raf transgenic mice

scientific article

Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety

scientific article published on 21 September 2009

Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network

scientific article

Transcriptional defect of an inherited NKX2-5 haplotype comprising a SNP, a nonsynonymous and a synonymous mutation, associated with human congenital heart disease

scientific article

Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes

scientific article

Transcriptomics does not show adverse effects of beta-carotene in A/J mice exposed to smoke for 2 weeks

scientific article published on 18 July 2007

Treatment of cyclosporine induced hypertension: Results from a long-term observational study using different antihypertensive medications

scientific article published on 19 June 2018

Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells

scientific article

Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart

scientific article published in September 2002

Vitamin E in heart transplantation: effects on cardiac gene expression

scientific journal article

Whole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcome

scientific article

c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma

scientific article published on September 2016

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