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List of works by Roberto P Garofalo

2385 Role of the antioxidant enzyme catalase in respiratory syncytial virus infection

A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis

scientific article published on 03 January 2020

A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein ⬇️

scientific article published on June 1, 2011

Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections

scientific article

Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection

scientific article

Antioxidant mimetics modulate oxidative stress and cellular signaling in airway epithelial cells infected with respiratory syncytial virus

scientific article

Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation

scientific article published on 28 September 2006

Antiviral and Immunomodulatory Activity of Silver Nanoparticles in Experimental RSV Infection

scientific article published on 08 August 2019

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.

scientific article

BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection.

scientific article published on 11 January 2017

Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

scientific article

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

scientific article published on 17 April 2013

Central Role of the NFκB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-induced Airway Inflammation.

scientific article published on 28 March 2018

Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

scientific article

Cigarette Smoke Condensate Exposure Changes RNA Content of Extracellular Vesicles Released from Small Airway Epithelial Cells

scientific article published on 17 December 2019

Cigarette smoke condensate enhances respiratory syncytial virus-induced chemokine release by modulating NF-kappa B and interferon regulatory factor activation

scientific article published on 22 August 2008

Critical role of TLR4 in human metapneumovirus mediated innate immune responses and disease pathogenesis

scientific article

Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke

scientific article published on 15 April 2019

Differential Activation of Human Monocyte-Derived and Plasmacytoid Dendritic Cells by West Nile Virus Generated in Different Host Cells

scientific article

Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection

scientific article published on 05 July 2013

Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus

scientific article

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

scientific article

Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition.

scientific article published on 5 June 2017

Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection

scholarly article by Eun-Jin Choi et al published 15 November 2018 in Journal of Virology

Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection.

scientific article

Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally

scientific article published on 28 July 2020

HIF-1α Modulates Core Metabolism and Virus Replication in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus

scientific article published on 26 September 2020

Human Metapneumovirus Glycoprotein G Inhibits TLR4-Dependent Signaling in Monocyte-Derived Dendritic Cells ⬇️

scientific article published on July 1, 2011

Human metapneumovirus glycoprotein G disrupts mitochondrial signaling in airway epithelial cells

scientific article

Human metapneumovirus glycoprotein G inhibits innate immune responses

scientific article published in May 2008

Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus

scientific article

Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels

scientific article

Human metapneumovirus small hydrophobic protein inhibits NF-kappaB transcriptional activity

scientific article published on 11 June 2008

Hydrogen Sulfide Is an Antiviral and Antiinflammatory Endogenous Gasotransmitter in the Airways. Role in Respiratory Syncytial Virus Infection.

scientific article

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases and Antiviral Defenses

scientific article published on 8 May 2017

IKKε modulates RSV-induced NF-κB-dependent gene transcription

scientific article

Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells

scientific article

IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection.

scientific article published on March 2004

Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway

scientific article published on 27 June 2006

Immunopathogenesis of respiratory syncytial virus bronchiolitis

scientific article published on 12 April 2007

Increased Lung Catalase Activity Confers Protection Against Experimental RSV Infection

scientific article published on 27 February 2020

Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice

scientific article

Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation

scientific article published on June 2002

LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity

scientific article

Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity

scientific article

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

scientific article published in Scientific Reports

MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression

scientific article published on August 2002

Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus

scientific article

Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment

scientific article (publication date: 2010)

MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis

scientific article published on 08 July 2013

Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis

scientific article

Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection

scientific article

Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells

scientific article

Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation

scientific article published in May 2002

Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors

scientific article

Proinflammatory Effects of Respiratory Syncytial Virus-Induced Epithelial HMGB1 on Human Innate Immune Cell Activation

scientific article published on 01 October 2018

Protective Role of Nuclear Factor Erythroid 2-Related Factor 2 Against Respiratory Syncytial Virus and Human Metapneumovirus Infections.

scientific article

RSV-induced prostaglandin E2 production occurs via cPLA2 activation: role in viral replication

scientific article published on 8 September 2005

Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases

scientific article published on 24 October 2003

Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation

scientific article published on 09 August 2002

RelA Ser276 Phosphorylation-Coupled Lys310 Acetylation Controls Transcriptional Elongation of Inflammatory Cytokines in Respiratory Syncytial Virus Infection ⬇️

scientific article published on September 7, 2011

Respiratory Syncytial Virus Infection Induces Chromatin Remodeling to Activate Growth Factor and Extracellular Matrix Secretion Pathways

scientific article published on 26 July 2020

Respiratory Syncytial Virus Infection Triggers Epithelial HMGB1 Release as a Damage-Associated Molecular Pattern Promoting a Monocytic Inflammatory Response.

scientific article published on 17 August 2016

Respiratory Syncytial Virus Infection: Mechanisms of Redox Control and Novel Therapeutic Opportunities ⬇️

scientific article published on September 7, 2012

Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein - ring finger protein 4 dependent pathway

scientific article published on 28 October 2017

Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I⋅NF- kappa B-inducing kinase signaling pathway

scientific article

Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes

scientific article

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2.

scientific article

Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression

scientific article published on 12 August 2009

Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-kappaB2.

scientific article published on July 2005

Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways

scientific article published on 11 October 2002

Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter

scientific article

Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells

scientific article published on 15 November 2006

Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells

scientific article

Robust Cytokine and Chemokine Response in Nasopharyngeal Secretions: Association With Decreased Severity in Children With Physician Diagnosed Bronchiolitis

scientific article published on 18 May 2016

Role of hydrogen sulfide in paramyxovirus infections

scientific article published on 4 March 2015

Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins

scientific article

Selective Blockade of TNFR1 Improves Clinical Disease and Bronchoconstriction in Experimental RSV Infection

scientific article published on 17 October 2020

Subversion of pulmonary dendritic cell function by paramyxovirus infections

scientific article

Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infections

scientific article published on 3 March 2017

T lymphocytes contribute to antiviral immunity and pathogenesis in experimental human metapneumovirus infection

scientific article published on 18 June 2008

TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infection ⬇️

scientific article published on August 10, 2011

The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis

scientific article

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

scientific article published on 2 December 2011

Viral-mediated Inhibition of Antioxidant Enzymes Contributes to the Pathogenesis of Severe Respiratory Syncytial Virus Bronchiolitis ⬇️

scientific article published on March 4, 2011

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