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List of works by Maria Chiara Monti

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis

article

Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei

article published in 2012

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

scientific article published on 16 February 2017

Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach

scientific article published on 29 October 2015

Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin

scientific article published in August 2016

Callipeltins F–I: new antifungal peptides from the marine sponge Latrunculia sp

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite

scientific article published on 02 June 2020

Characterization of a New Mixture of Mono-Rhamnolipids Produced by Pseudomonas gessardii Isolated from Edmonson Point (Antarctica)

scientific article published on 20 May 2020

Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

scientific article published on 24 July 2012

Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.

scientific article published on May 2010

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.

scientific article published on 8 November 2010

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.

scientific article published on 24 May 2013

Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclooxygenase, NF-kappaB and other unidentified targets

scientific article (publication date: 2006)

Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase

scientific article published on 01 November 2018

Concise Synthesis of All Stereoisomers of β-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A

scientific article published on 01 August 2005

Crellastatin A, a PARP-1 Inhibitor Discovered by Complementary Proteomic Approaches

scientific article published on 08 January 2020

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids

article

Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.

scientific article

Determining the Effect of Pterostilbene on Insulin Secretion Using Chemoproteomics

scientific article published on 23 June 2020

Differential in gel electrophoresis (DIGE) comparative proteomic analysis of macrophages cell cultures in response to perthamide C treatment

scientific article published on 17 April 2013

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.

scientific article published on 13 October 2017

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

scientific article published on 21 February 2019

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

scientific article (publication date: 2012)

Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.

scientific article published on 08 July 2013

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones

scientific article published on 04 May 2022

Effects of petrosaspongiolide R on the surface topology of bee venom PLA(2): a limited proteolysis and mass spectrometry analysis

scientific article

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

scientific article

Further insights on the structural aspects of PLA(2) inhibition by gamma-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M-R.

scientific article published in March 2004

Genomics-Metabolomics Profiling Disclosed Marine Vibrio spartinae 3.6 as a Producer of a New Branched Side Chain Prodigiosin ⬇️

scientific article published on 10 April 2020

Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice.

scientific article

Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C.

scientific article published on 10 February 2012

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

scientific article published in January 2014

Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

scientific article

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

scientific article published on 15 July 2015

In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component

scientific article published on 01 June 2015

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists.

scientific article published on 7 January 2016

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

scientific article published on 16 March 2019

Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

scientific article published on 10 January 2019

Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone

scientific article published on 11 June 2021

Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy.

scientific article published on 14 February 2014

Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2

scientific article published on 07 December 2020

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)

scientific article published on 07 September 2014

Modulation of Proteasome Machinery by Natural and Synthetic Analogues of the Marine Bioactive Compound Petrosaspongiolide M ⬇️

scientific article published on March 21, 2012

Modulation of tau protein fibrillization by oleocanthal.

scientific article published on 18 September 2012

N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization

scientific article published on 04 February 2014

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

scientific article

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

scientific article published on 07 July 2011

Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury

scientific article published on 06 December 2018

Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions

scientific article published on 8 November 2014

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis

scientific article published on 01 May 2020

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

scientific article

Proteasome as a New Target for Bio-Inspired Benzo[k,l]xanthene Lignans.

scientific article

Proteomic Analysis of Zn Depletion/Repletion in the Hormone-Secreting Thyroid Follicular Cell Line FRTL-5

scientific article published on 14 December 2018

Quantitative proteomics discloses monacolin K-induced alterations in triple-negative breast cancer cell proteomes and phosphoproteomes

scientific article published on 01 February 2020

Quantum Mechanical Calculation of Coupling Constants in the Configurational Analysis of Flexible Systems: Determination of the Configuration of Callipeltin A

Retracted: Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo

retracted article

Scalaradial, a Dialdehyde-Containing Marine Metabolite That Causes an Unexpected Noncovalent PLA2 Inactivation

scientific article published on 01 September 2007

Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

scientific article

Serum Bile Acid Levels Before and After Sleeve Gastrectomy and Their Correlation with Obesity-Related Comorbidities

scientific article published on 01 August 2019

Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues ⬇️

scientific article published on November 24, 2010

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases

scientific article published on 30 March 2017

The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.

scientific article published on 15 October 2015

The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling.

scientific article published on 3 May 2016

The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy

scientific article published on 01 January 2021

The binding mode of cladocoran A to the human group IIA phospholipase A(2).

scientific article

The binding mode of petrosaspongiolide M to the human group IIA phospholipase A(2): exploring the role of covalent and noncovalent interactions in the inhibition process

scientific article published in January 2009

The inactivation mechanism of human group IIA phospholipase A(2) by Scalaradial

scientific article published on 24 September 2012

The inactivation of phospholipase A2 by scalaradial: a biomimetic study by electrospray mass spectrometry

scientific article published in January 2005

The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone

scientific article published on 01 June 2006

The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone.

scientific article published in November 2009

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate

scientific article

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation.

scientific article

Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH

scientific article published on 17 July 2019

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