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List of works by Takahiro Ochiya

"Stem cells into liver"--basic research and potential clinical applications.

scientific article published on January 2006

A Challenge to Aging Society by microRNA in Extracellular Vesicles: microRNA in Extracellular Vesicles as Promising Biomarkers and Novel Therapeutic Targets in Multiple Myeloma

scientific article published on 12 March 2018

A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network

scientific article published on 07 July 2018

A combination of circulating miRNAs for the early detection of ovarian cancer

scientific article published on 6 September 2017

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

scientific article published on 19 March 2020

A novel platform to enable inhaled naked RNAi medicine for lung cancer.

scientific article

A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications

scientific article published on January 2014

A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination

scientific article published on August 2006

A robust screening method for dietary agents that activate tumour-suppressor microRNAs

scientific article published on October 2015

A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes

scientific article published on 21 March 2019

A tissue microRNA signature that predicts the prognosis of breast cancer in young women

scientific article published on 15 November 2017

Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes

scientific article published on 10 April 2020

Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes

scientific article published on 01 July 2007

Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake

scientific article published on 13 January 2020

An Insight into the Roles of MicroRNAs and Exosomes in Sarcoma

An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells

scientific article

Antisense oligodeoxynucleotide against HST‐1/FGF‐4 suppresses tumorigenicity of an orthotopic model for human germ cell tumor in nude mice ⬇️

scientific article published on November 1, 2003

Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan

scientific article

Assessment of the Diagnostic Utility of Serum MicroRNA Classification in Patients With Diffuse Glioma

scientific article published on 02 December 2019

Atelocollagen for protein and gene delivery ⬇️

scientific article published on November 28, 2003

Atelocollagen-mediated drug discovery technology ⬇️

scientific article published on February 1, 2007

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

scientific article published on 22 July 2004

Atelocollagen-mediated systemic DDS for nucleic acid medicines

scientific article published on 01 October 2006

Biliary Epithelial Cells Play an Essential Role in the Reconstruction of Hepatic Tissue with a Functional Bile Ductular Network ⬇️

scientific article published on July 16, 2013

Biocompatibility of highly purified bovine milk-derived extracellular vesicles.

scientific article published on 21 February 2018

Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages

scientific article

Brain metastasis-related microRNAs in patients with advanced breast cancer

scientific article published on 11 October 2019

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier

scientific article

CD44 exerts a functional role during EMT induction in cisplatin-resistant head and neck cancer cells

scientific article published on 13 January 2018

CD44s Induces miR-629-3p Expression in Association with Cisplatin Resistance in Head and Neck Cancer Cells

scientific article published on 01 April 2020

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts

scientific article published on 17 June 2020

Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts

scientific article published on 30 May 2019

Cancer stem cells in breast cancer

scientific article published on 15 March 2011

Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma

scientific article published on 07 December 2012

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.

scientific article published on 12 February 2018

Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells

scientific article published on 25 February 2020

Central genetic alterations common to all HCV-positive, HBV-positive and non-B, non-C hepatocellular carcinoma: a new approach to identify novel tumor markers

scientific article published on February 2006

Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice.

scientific article published on 3 June 2016

Chaperon-Mediated Autophagy Receptor Modulates Tumor Growth and Chemoresistance in Non-Small Cell Lung Cancer

scientific article published on 28 August 2020

Chemically Induced Liver Progenitors (CLiPs): A Novel Cell Source for Hepatocytes and Biliary Epithelial Cells

scientific article published on 01 January 2019

Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c

scientific article

Circulating Exosomal miRNA Profiles Predict the Occurrence and Recurrence of Hepatocellular Carcinoma in Patients with Direct-Acting Antiviral-Induced Sustained Viral Response

scientific article published on 03 November 2019

Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma

scientific article published on 7 November 2017

Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer

scientific article published on 12 December 2018

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

scientific article

Circulating microRNAs and extracellular vesicles as potential cancer biomarkers: a systematic review

scientific article published on 27 February 2017

Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?

scientific article published in January 2015

Clinical Application of Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapeutics for Inflammatory Lung Diseases

article

Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells

scientific article published in April 2014

Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma

scientific article

Combined functional genome survey of therapeutic targets for hepatocellular carcinoma

scientific article published on 13 April 2010

Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles

scientific article published on 26 November 2015

Commitment of stem cells into functional hepatocytes

scientific article

Comparative marker analysis of extracellular vesicles in different human cancer types

scientific article published on 18 June 2013

Competitive interactions of cancer cells and normal cells via secretory microRNAs

scientific article published on 28 November 2011

Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.

scientific article

Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease

scientific article

Control of HCV Replication With iMIRs, a Novel Anti-RNAi Agent

scientific article published on January 2015

Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity

scientific article published in November 2016

Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis

DSE-FRET: A new anticancer drug screening assay for DNA binding proteins

scientific article

Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy.

scientific article published on March 2014

Delivery of miR-424-5p via Extracellular Vesicles Promotes the Apoptosis of MDA-MB-231 TNBC Cells in the Tumor Microenvironment ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2021

Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling

scientific article published on 03 May 2019

Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer

scientific article published on 01 June 2005

Development of miRNA-based therapeutic approaches for cancer patients

article

Development of small RNA delivery systems for lung cancer therapy.

scientific article

Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells

scientific article published on 26 April 2018

Differentiation of embryonic stem cells into hepatocytes: Biological functions and therapeutic application ⬇️

scientific article published on May 1, 2003

Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch

scientific article published on 18 November 2020

Direct hepatic fate specification from mouse embryonic stem cells

scientific article published in April 2005

Drug Resistance Driven by Cancer Stem Cells and Their Niche

scientific article published in December 2017

Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer

scientific article published on 09 March 2019

Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas

scientific article

Efficacy of a novel class of RNA interference therapeutic agents

scientific article

Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4.

scientific article published on 21 April 2016

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

scientific article published on 13 November 2017

Emerging roles of long non-coding RNA in cancer.

scientific article published on 28 June 2018

Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor

scientific article published on 01 December 2010

Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation.

scientific article published in March 2002

Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment

scientific article published on 22 November 2017

Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells

scientific article published on 27 April 2018

Epithelial stem cell culture: modeling human disease and applications for regenerative medicine

scientific article published on 6 February 2017

Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.

scientific article published on 15 December 2015

Establishment of embryonic stem cells from rat blastocysts

scientific article

Establishment of rat embryonic stem cells and making of chimera rats

scientific article

Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer

scientific article published on 24 July 2015

Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment

scientific article

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.

scientific article

Exosomes: toward clinical application

scientific article published on January 2017

Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications

scientific article published in 2019

Expression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection

scientific article published on 9 April 2016

Extracellular Vesicles Are Key Regulators of Tumor Neovasculature

scientific article published on 09 December 2020

Extracellular Vesicles from Fibroblasts Induce Epithelial Cell Senescence in Pulmonary Fibrosis

scientific article published on 30 July 2020

Extracellular Vesicles in Bone Metastasis: Key Players in the Tumor Microenvironment and Promising Therapeutic Targets

scientific article published on 12 September 2020

Extracellular Vesicles in Cancer Metastasis: Potential as Therapeutic Targets and Materials

scientific article published on 23 June 2020

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease

scientific article

Extracellular Vesicles: New Players in Lung Immunity

scientific article published on 8 November 2017

Extracellular miRNAs for the Management of Barrett's Esophagus and Esophageal Adenocarcinoma: A Systematic Review

scientific article published on 31 December 2020

Extracellular microRNAs and oxidative stress in liver injury: a systematic mini review

article

Extracellular vesicle transfer of cancer pathogenic components

scientific article published in April 2016

Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma

scientific article published on 27 November 2017

Extracellular vesicles and encapusulated miRNAs as emerging cancer biomarkers for novel liquid biopsy

scientific article published on 01 October 2018

Extracellular vesicles as biomarkers and therapeutic targets for cancer

scientific article published on 06 November 2019

Extracellular vesicles as trans-genomic agents: Emerging roles in disease and evolution.

scientific article

Extracellular vesicles in lung cancer-From bench to bedside

scientific article

Extracellular vesicles in lung microenvironment and pathogenesis

scientific article published on 28 July 2015

Extracellular vesicles in smoking-related lung diseases

scientific article published on 10 December 2015

Extracellular vesicles mediate the horizontal transfer of an active LINE-1 retrotransposon

scientific article published on 23 July 2019

Extracellular vesicles: Toward a clinical application in urological cancer treatment

scientific article published on 03 May 2018

FGF-4 regulates neural progenitor cell proliferation and neuronal differentiation

scientific article published on 24 May 2006

Functional analysis of exosomal microRNA in cell-cell communication research

scientific article published on January 2013

Gene expression profiling of cerebellar development with high-throughput functional analysis

scientific article published on 29 March 2005

Gene-manipulated embryonic stem cells for rat transgenesis

scientific article published on 25 March 2011

Generation of Hepatic Organoids with Biliary Structures

scientific article published on 01 January 2019

Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids

scientific article published on 19 August 2016

Generation of functional human hepatocytes in vitro: current status and future prospects

scientific article published on 02 July 2019

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

scientific article published on 08 August 2019

Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system

scientific article published on 23 December 2013

Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells ⬇️

scientific article published on July 3, 2012

Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma.

scientific article published on 30 April 2016

Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer

scientific article published on July 2006

High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors

scientific article published on 08 October 2015

Highly Sensitive Circulating MicroRNA Panel for Accurate Detection of Hepatocellular Carcinoma in Patients With Liver Disease

scientific article published on 19 December 2019

How cancer cells dictate their microenvironment: present roles of extracellular vesicles

scientific article published on 31 August 2016

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

scientific article

Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors

scientific article

Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells

scientific article

Identification of erythropoietin-induced microRNAs in haematopoietic cells during erythroid differentiation.

scientific article

Identification of serum microRNAs predicting the response of esophageal squamous-cell carcinoma to nivolumab

scientific article published on 01 February 2020

Imaging and Antitumoral Effect of a Cyclo-oxygenase 2-specific Replicative Adenovirus for Small Metastatic Gastric Cancer Lesions.

scientific article published on October 2015

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models ⬇️

scientific article published on August 17, 2012

In Vivo Imaging of Oligonucleotide Delivery ⬇️

scientific article published on January 1, 2012

Induced pluripotent stem cell-derived hepatocytes as an alternative to human adult hepatocytes

scientific article published on January 1, 2012

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis ⬇️

scientific article published on February 27, 2012

Inhibition of nuclear factor‐kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion ⬇️

scientific article published on March 1, 2011

Integrated extracellular microRNA profiling for ovarian cancer screening

scientific article published in Nature Communications

Intercellular communication by extracellular vesicles and their microRNAs in asthma.

scientific article

Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice ⬇️

scientific article published on December 13, 2012

Involvement of Extracellular Vesicles in Vascular-Related Functions in Cancer Progression and Metastasis.

scientific article

In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules

scientific article published on 18 November 2016

LGR5‐Positive Colon Cancer Stem Cells Interconvert with Drug‐Resistant LGR5‐Negative cells and are Capable of Tumor Reconstitution ⬇️

scientific article published on December 1, 2012

Large-scale Circulating microRNA Profiling for the Liquid Biopsy of Prostate Cancer

scientific article published on 26 February 2019

Latest advances in extracellular vesicles: from bench to bedside

scientific article published on 17 June 2019

Local and systemic delivery of siRNAs for oligonucleotide therapy

scientific article published in January 2009

Long-term maintenance of functional primary human hepatocytes using small molecules

scientific article published on 30 August 2019

Long-term maintenance of liver-specific functions in cultured ES cell-derived hepatocytes with hyaluronan sponge

scientific article published in January 2005

Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1.

scientific article published on 12 June 2015

MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells

scientific article published on 18 July 2019

MOZ is essential for maintenance of hematopoietic stem cells

scientific journal article

Maintaining good miRNAs in the body keeps the doctor away?: Perspectives on the relationship between food-derived natural products and microRNAs in relation to exosomes/extracellular vesicles.

scientific article published on 8 June 2017

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

scientific article

Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis resulting from gastric cancer.

scientific article published on February 2014

Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer's disease

scientific article published on 10 February 2017

MiR-1285-5p/TMEM194A axis affects cell proliferation in breast cancer

scientific article published on 23 January 2020

MicroRNA-124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells

scientific article published on 30 December 2019

MicroRNA-125b expression and intrahepatic metastasis are predictors for early recurrence after hepatocellular carcinoma resection

scientific article published on 6 October 2017

MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression ⬇️

scientific article published on March 22, 2011

MicroRNA-493-5p-mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion

scientific article published on 25 January 2020

MicroRNAs in soft tissue sarcomas: overview of the accumulating evidence and importance as novel biomarkers

scientific article

Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins

scientific article

Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair

scientific article

NEK9-dependent proliferation of cancer cells lacking functional p53

scientific article

Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis

scientific article published on 25 February 2013

Novel combination of serum microRNA for detecting breast cancer in the early stage.

scientific article published on 7 January 2016

Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4

scientific article published on 29 May 2020

On-chip immunoelectrophoresis of extracellular vesicles released from human breast cancer cells

scientific article published on 30 April 2015

One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation

scientific article published on 5 April 2007

Pazopanib-induced changes in protein expression signatures of extracellular vesicles in synovial sarcoma

scientific article published on 27 October 2018

Peripheral neuropathy from paclitaxel: risk prediction by serum microRNAs

scientific article published on 14 January 2020

Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application

scientific article published on April 2014

Pleiotropic function of FGF-4: its role in development and stem cells

scientific article published on February 2009

Potential application of extracellular vesicles of human adipose tissue-derived mesenchymal stem cells in Alzheimer's disease therapeutics

scientific article

Potential of atelocollagen-mediated systemic antisense therapeutics for inflammatory disease

scientific article published in March 2004

Profiling of circulating microRNAs for prostate cancer biomarker discovery.

scientific article published on February 2014

Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.

scientific article

Purification of RNA from Milk Whey ⬇️

scientific article published on January 1, 2013

RNAi Therapeutic Platforms for Lung Diseases

scientific article published on 06 February 2013

RNAi Therapeutics and Applications of MicroRNAs in Cancer Treatment ⬇️

scientific article published on April 16, 2013

RNAi-based drug discovery and its application to therapeutics

scientific article published on 01 April 2008

RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis

scientific article

RPN2 gene confers docetaxel resistance in breast cancer

scientific journal article

Re: A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2-10ng/ml at Initial Biopsy

scientific article published on 22 March 2019

Real-time in vivo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents ⬇️

scientific article published on March 15, 2012

Regenerative cells for transplantation in hepatic failure

scientific article published on January 2012

Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer.

scientific article published on 15 May 2018

Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β ⬇️

scientific article published on January 1, 2013

Screening of microRNAs for a repressor of hepatitis B virus replication

Screening of potential molecular targets for colorectal cancer therapy.

scientific article

Secretory mechanisms and intercellular transfer of microRNAs in living cells

scientific article

Secretory microRNAs as a versatile communication tool

scientific article

Sensation of Abdominal Pain Induced by Peritoneal Carcinomatosis Is Accompanied by Changes in the Expression of Substance P and μ-Opioid Receptors in the Spinal Cord of Mice ⬇️

scientific article published on October 1, 2012

Serum MicroRNA-Based Risk Prediction for Stroke

scientific article published on 15 April 2019

Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis.

scientific article published on 05 September 2016

Serum miRNA-based Prediction of Axillary Lymph Node Metastasis in Breast Cancer

scientific article published on 27 November 2018

Serum microRNA profile enables preoperative diagnosis of uterine leiomyosarcoma

scientific article published on 16 November 2019

Serum microRNA-based prediction of responsiveness to eribulin in metastatic breast cancer

scientific article published on 04 September 2019

Single-Cell Analysis Reveals a Preexisting Drug-Resistant Subpopulation in the Luminal Breast Cancer Subtype

scientific article published on 09 July 2019

Stem cell plasticity: learning from hepatogenic differentiation strategies

scientific article published on December 2007

Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells

scientific article published on June 2010

Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity ⬇️

scientific article published on March 15, 2012

Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis

scientific article

Syngeneic Hematopoietic Stem Cell Transplantation Enhances the Antitumor Immunity of Intratumoral Type I Interferon Gene Transfer for Sarcoma ⬇️

scientific article published on January 26, 2012

Synthetic Lethality in Lung Cancer-From the Perspective of Cancer Genomics

Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes

scientific article

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells ⬇️

scientific article published on October 2, 2012

TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion

scientific article

Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner

scientific article

The Functional Role of Exosomes in Cancer Biology and Their Potential as Biomarkers and Therapeutic Targets of Cancer

scientific article published in June 2015

The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity

scientific article published on 12 July 2019

The Roles of MicroRNAs in Breast Cancer

scientific article published on 9 April 2015

The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking neural stem cell-derived extracellular vesicles.

scientific article published on 30 November 2017

The biological role of exosomes in bone remodeling and bone diseases

scientific article published in January 2018

The clinical impact of intra- and extra-cellular miRNAs in ovarian cancer

scientific article published on 04 August 2020

The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer

scientific article

The expression and clinical significance of ribophorin II (RPN2) in human breast cancer

scientific article

The impact of extracellular vesicle-encapsulated circulating microRNAs in lung cancer research

scientific article

The in vivo evaluation of the therapeutic potential of human adipose tissue-derived mesenchymal stem cells for acute liver disease

scientific article published on 01 January 2014

The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas.

scientific article

The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families

scientific article

The role of atelocollagen-based cell transfection array in high-throughput screening of gene functions and in drug discovery

scientific article

The role of extracellular vesicle microRNAs in cancer biology

scientific article published on 23 February 2017

The role of microRNAs in the regulation of cancer stem cells

scientific article published on 03 January 2014

The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers

scientific article published on March 2014

The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

scientific article published on 13 December 2017

The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles ⬇️

scientific article published on February 26, 2013

Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression ⬇️

scientific article published on January 8, 2013

Therapeutic potential of RNA interference against cancer

scientific article

Three-Dimensional Culture of Fetal Mouse, Rat, and Porcine Hepatocytes

scientific article published on 5 December 2012

Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey

scientific article

Towards Circulating-Tumor DNA-Based Precision Medicine

scientific article published on 02 September 2019

Towards the realization of clinical extracellular vesicle diagnostics: challenges and opportunities

scientific article

Transcriptomic Dissection of Hepatocyte Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell Characteristics

scientific article published on 05 September 2019

Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis

scientific article published in July 2002

Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles

scientific article published on 24 October 2016

Transplantation of Thy1+ Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-Like Progenitor Cells via IL17RB Signaling.

scientific article published on 7 December 2016

Transplantation of a fetal liver cell-loaded hyaluronic acid sponge onto the mesentery recovers a Wilson's disease model rat.

scientific article published on 18 June 2010

Trash or Treasure: extracellular microRNAs and cell-to-cell communication

scientific article published in 2013

Two distinct knockout approaches highlight a critical role for p53 in rat development ⬇️

scientific article published on December 10, 2012

Type I collagen gene suppresses tumor growth and invasion of malignant human glioma cells

scientific article published on 20 June 2007

UBL3 modification influences protein sorting to small extracellular vesicles

scientific article published in Nature Communications

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

scientific article

Uncovering temperature-dependent extracellular vesicle secretion in breast cancer

scientific article published on 31 December 2020

Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells ⬇️

scientific article published on January 3, 2012

Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires

scientific article published on 15 December 2017

Update on microRNAs research in sarcoma: review the literature and proposal of the clinical application

scientific article published on March 1, 2013

Usefulness of serum microRNA as a predictive marker of recurrence and prognosis in biliary tract cancer after radical surgery

Versatile Applications of microRNA in Anti-Cancer Drug Discovery: From Therapeutics to Biomarkers ⬇️

scientific article published on June 1, 2010

Versatile roles of extracellular vesicles in cancer

scientific article published on 14 March 2016

[Application of atelocollagen-mediated siRNA delivery for RNAi therapies]

scientific article published on 01 May 2007

[Application of microRNAs to Cancer Therapy]

scientific article published on 01 March 2010

[MicroRNA in Body Fluids - Development of the Novel Plat Form for Cancer Therapeutics and Diagnosis]

scientific article published on 01 June 2018

miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma.

scientific article

miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells

scientific article published on 30 July 2013

miR-22 represses cancer progression by inducing cellular senescence

scientific article

miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases ⬇️

scientific article published on July 12, 2013

microRNA as a new immune-regulatory agent in breast milk

scientific article

microRNAs act as a fine-tuner of liver development, regeneration, and carcinogenesis

scientific article published on August 1, 2012

microRNAs and Hepatitis B.

scientific article

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