List of works by Kees L M C Franken

A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice

scientific article published on 24 October 2012

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

scientific article published on 08 July 2022

Adenovirus-specific CD4+ T cell clones recognizing endogenous antigen inhibit viral replication in vitro through cognate interaction

An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection

scientific article published on 14 January 2013

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa

scientific article

Analysis of immune responses against a wide range of Mycobacterium tuberculosis antigens in patients with active pulmonary tuberculosis

scientific article published on 26 September 2012

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

article

Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells

scientific article published on 01 November 2002

Apparent Lack of BRAF V600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis

scientific article published on 01 January 2019

Application of new host biomarker profiles in quantitative point-of-care tests facilitates leprosy diagnosis in the field

scientific article published on 14 August 2019

Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen

scientific article published on 01 October 2008

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

scientific article

CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.

scientific article published on 10 April 2013

CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity

scientific article published in October 2012

CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity

scientific article

CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis

scientific article

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

scientific article published on 11 February 2020

Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model

scientific article

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method

scientific article

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

scientific article

Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria

scientific article published on 08 September 2009

Cytokine responses to Mycobacterium leprae unique proteins differentiate between Mycobacterium leprae infected and naive armadillos.

scientific article

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

scholarly article

DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg

scientific article published in July 2009

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

scientific article published on 5 August 2013

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+ T cells

scientific article published on 9 November 2017

Detection of IgG1 antibodies against Mycobacterium tuberculosis DosR and Rpf antigens in tuberculosis patients before and after chemotherapy.

scientific article published on 30 November 2015

Detection of Mycobacterium leprae infection employing a combinatorial approach of anti-45 kDa and modified anti-PGL-I antibody detection assays

scientific article published on 01 August 2007

Development of a mouse food pad model for detection of sub clinical leprosy

scientific article published on 01 December 2011

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.

scientific article published in June 2011

Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

scientific article published on 30 August 2011

Dynamics of the T cell response to Mycobacterium tuberculosis DosR and Rpf antigens in a Colombian population of household contacts of recently diagnosed pulmonary tuberculosis patients

scientific article published on 21 January 2016

ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia

scientific article

Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines

scientific article published on 10 May 2011

Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays

scientific article published on 28 April 2010

Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.

scientific article

Evaluation of immunological cross-reactivity between clade A9 high-risk human papillomavirus types on the basis of E6-Specific CD4+ memory T cell responses

scientific article published on October 2010

Evaluation of recombinant serine-rich 45-kDa antigen (ML0411) for detection of antibodies in leprosy patients

scientific article published on 01 October 2006

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

scientific article published on 20 January 2005

Excision Repair Cross-Complementation group 1 (ERCC1) C118T SNP does not affect cellular response to oxaliplatin

scientific article published on 9 November 2013

Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. ⬇️

scientific article

Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.

scientific article

Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter

article

From genome-based in silico predictions to ex vivo verification of leprosy diagnosis

scientific article published on 28 January 2009

Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood

scientific article (publication date: 2011)

Host cytokine responses induced after overnight stimulation with novel M. tuberculosis infection phase-dependent antigens show promise as diagnostic candidates for TB disease

scientific article

Human CD4+ T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirus

scientific article published in September 2006

Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis

scientific article published on 13 June 2006

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection.

scientific article published on February 2017

IL-6-mediated resistance to immunotherapy is linked to impaired myeloid cell function

scientific article published on 01 September 2020

Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis

scientific article published on May 2002

Identification of HLA-E Binding -Derived Epitopes through Improved Prediction Models

scholarly article

Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules

scientific article published on 01 January 1999

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

scientific article published on 13 October 2019

Identification of citrullinated vimentin peptides as T cell epitopes in HLAâ DR4â positive patients with rheumatoid arthritis

scientific article published on 01 January 2010

Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation-promoting factors in long-term latently infected individuals

scientific article

Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8+ T cells in HLA-transgenic mice and humans

scientific article

IgA response to ESAT-6/CFP-10 and Rv2031 antigens varies in patients with culture-confirmed pulmonary tuberculosis, healthy Mycobacterium tuberculosis-infected and non-infected individuals in a tuberculosis endemic setting, Ethiopia.

scientific article published in September 2013

Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells

scientific article published on 01 February 1998

Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and Africa

scientific article published in December 2011

Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice

scientific article

Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa

scientific article published on 24 June 2009

Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis

scientific article published on 01 January 2004

Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy

scientific article

Increased intracellular survival of Mycobacterium smegmatis containing the Mycobacterium leprae thioredoxin-thioredoxin reductase gene.

scientific article

Interferon-gamma production in response to M. tuberculosis antigens in TB patients in Indonesia

scientific article

Interferon-γ responses to Mycobacterium tuberculosis Rpf proteins in contact investigation.

scientific article published on 17 August 2013

Interleukin-6 and Mycobacterium tuberculosis dormancy antigens improve diagnosis of tuberculosis

scientific article published on 02 December 2020

Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction.

scientific article published on February 2004

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination

scientific article published on 14 May 2007

Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma

scientific article

Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer.

scientific article published in January 2001

Longitudinal immune profiles in type 1 leprosy reactions in Bangladesh, Brazil, Ethiopia and Nepal

scientific article published on 28 October 2015

Longitudinal immune responses and gene expression profiles in type 1 leprosy reactions

scientific article published on 27 December 2013

ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria

scientific article published on 24 June 2011

Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors.

scientific article

Monokine induced by interferon gamma and IFN-gamma response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients

scientific article published on 22 July 2005

Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa

scientific article

Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia

scientific article published on 03 August 2016

Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists

scientific article published on 7 November 2006

Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal

scientific article published on December 2012

Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes.

scientific article

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

scientific article

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy

scientific article

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

scientific article published on 05 October 2020

Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls

scientific article published on 29 January 2012

Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection

scientific article

Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia

scientific article published on 8 January 2018

Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area

scientific article

Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

scientific article

Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer

scientific article published in August 2008

Pro- and anti-inflammatory cytokines against Rv2031 are elevated during latent tuberculosis: a study in cohorts of tuberculosis patients, household contacts and community controls in an endemic setting

scientific article published on 21 April 2015

Production and Thermal Exchange of Conditional Peptide-MHC I Multimers

scientific article published on 01 September 2019

Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice.

scientific article published on 3 May 2009

Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis

scientific article

Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent

scientific article published on 01 February 2000

Rapid assessment of the antigenic integrity of tetrameric HLA complexes by human monoclonal HLA antibodies.

scientific article published on 30 August 2006

Rapid enrichment of human papillomavirus (HPV)-specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer.

scientific article published on March 2005

Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection

scientific article published on 16 January 2008

Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection

scientific article published on 19 November 2009

SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity

scientific journal article

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

scientific article

Serological heterogeneity against various Mycobacterium leprae antigens and its use in serodiagnosis of leprosy patients

scientific article published on 01 September 2007

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

scientific article

Simultaneous immunization against tuberculosis

scientific article (publication date: 2011)

Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

scientific article

Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

scientific article

Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis

scientific article published on 22 July 2015

T cell immune responses to mycobacterial antigens in Brazilian tuberculosis patients and controls

article

T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia

scientific article published on 5 January 2012

T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy

scientific article published on 12 July 2011

T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination

scientific article published on 26 March 2007

T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients

scientific article

The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study

scientific article

The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities.

scientific article published on 2 March 2014

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs

scientific article published on 14 May 2014

The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.

scientific article

Therapeutic immunization and local low-dose tumor irradiation, a reinforcing combination

scientific article published on 4 September 2013

Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana

scientific article published on 03 July 2019

Use of resuscitation promoting factors to screen for tuberculosis infection in household-exposed children in The Gambia

scientific article published on 02 July 2020

Use of resuscitation-promoting factor proteins improves the sensitivity of culture-based tuberculosis testing in special samples

scientific article published on 01 March 2014

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application.

scientific article published on 26 February 2018

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