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List of works by Patrick Hwu

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

scientific article (publication date: 28 June 2012)
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

scientific article published on July 2003
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

scientific article
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

scientific article
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.

scientific article published on 2 November 2017
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

scientific article
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.

scientific article published on 10 January 2013
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma

scientific article
T helper 17 cells promote cytotoxic T cell activation in tumor immunity

scientific article
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

scientific article
Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.

scientific article published on 8 December 2015
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer

scientific article
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

scientific article published on 09 September 2016
PD-L1 Expression in Triple-Negative Breast Cancer

scientific article published on January 10, 2014
NRAS mutation status is an independent prognostic factor in metastatic melanoma

scientific article
Chimeric antigen receptor T-cell therapy - assessment and management of toxicities.

scientific article
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

scientific article published on 14 June 2016
Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma

scientific article
Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor

scientific article published on 17 December 2012
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion

scientific article published on 3 March 2013
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines

scientific article
A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma

scientific article
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients

scientific article
Prognostic factors for survival in melanoma patients with brain metastases

scientific article published on October 19, 2010
BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice

scientific article published on November 30, 2012
Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

scientific article published on 5 February 2016
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.

scientific article
Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma

scientific article
Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer

scholarly article
Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice

scientific article published in March 2008
Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2

scientific article published on 01 November 2002
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

article
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

scientific article
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates

scientific article
Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

scientific article published on 8 October 2018
Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.

scientific article published on 12 February 2018
Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook

scientific article
Pathways and therapeutic targets in melanoma

scientific article published on April 15, 2014
Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses

scientific article
IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

scientific article published on January 1, 2014
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

scientific article
Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo.

scientific article
Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy

scientific article published on 7 November 2016
In vivo antitumor activity of interleukin 21 mediated by natural killer cells

scientific article published on 01 December 2003
Correlation of NRAS Mutations With Clinical Response to High-dose IL-2 in Patients With Advanced Melanoma

scientific article published on January 1, 2012
Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma

scientific article
Radiologic manifestations of immune-related adverse events in patients with metastatic melanoma undergoing anti-CTLA-4 antibody therapy

scientific article published in December 2011
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

scientific article published on 05 April 2018
Immunization of patients with metastatic melanoma using both class I- and class II-restricted peptides from melanoma-associated antigens

scientific article

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