List of works - Manuel Ascano

A quantification of pathway components supports a novel model of Hedgehog signal transduction

scientific article published on 28 August 2009

An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling

scientific article published on December 2004

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.

scientific article published on 07 June 2016

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

scientific article

Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway

scientific article

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

scientific article

Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP

scientific article published on 03 May 2020

Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis

scientific article published on 04 July 2019

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

scientific article published on 21 January 2019

Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing

scientific article published on 22 June 2015

Eukaryote-specific insertion elements control human ARGONAUTE slicer activity

scientific article

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease

scientific article

FMRP targets distinct mRNA sequence elements to regulate protein expression

scientific journal article

G3BP1 enhances cytoplasmic DNA pattern recognition

scientific article published on 01 January 2019

Identification of RNA-protein interaction networks using PAR-CLIP

scientific article

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2 ⬇️

scientific article published on November 11, 2003

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

scientific article published on 30 June 2011

Multi-disciplinary methods to define RNA–protein interactions and regulatory networks ⬇️

scientific article published on February 28, 2013

Multimeric assembly and biochemical characterization of the Trax–translin endonuclease complex

scientific article

New insights in the mechanism of microRNA-mediated target repression

scientific article published on 4 November 2011

PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins

scientific article

PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins

scientific article

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

scientific article published on 23 November 2017

Regulation of Hedgehog signaling: a complex story

scientific article

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

scientific article published on 29 September 2017

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

scientific article published on 05 May 2020

Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms

scientific article published on 19 January 2006

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

scientific article

The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner

scientific article published on 28 November 2003

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

scientific article

The full-length unprocessed hedgehog protein is an active signaling molecule

scientific article

Transcriptome-Wide Identification of Protein Binding Sites on RNA by PAR-CLIP (Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation)

scientific article

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

scientific article

Viral crosslinking and solid-phase purification enables discovery of ribonucleoprotein complexes on incoming RNA virus genomes

scientific article published on 02 December 2020

List of works by Manuel Ascano

A quantification of pathway components supports a novel model of Hedgehog signal transduction

An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP

Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing

Eukaryote-specific insertion elements control human ARGONAUTE slicer activity

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease

FMRP targets distinct mRNA sequence elements to regulate protein expression

G3BP1 enhances cytoplasmic DNA pattern recognition

Identification of RNA-protein interaction networks using PAR-CLIP

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2 ⬇️

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

Multi-disciplinary methods to define RNA–protein interactions and regulatory networks ⬇️

Multimeric assembly and biochemical characterization of the Trax–translin endonuclease complex

New insights in the mechanism of microRNA-mediated target repression

PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins

PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Regulation of Hedgehog signaling: a complex story

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

The full-length unprocessed hedgehog protein is an active signaling molecule

Transcriptome-Wide Identification of Protein Binding Sites on RNA by PAR-CLIP (Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation)

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

Viral crosslinking and solid-phase purification enables discovery of ribonucleoprotein complexes on incoming RNA virus genomes