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List of works by Jay D Horton

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.

scientific article

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

scientific article

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue.

scientific article published on 13 May 2016

Acetate dependence of tumors

scientific article

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

scientific article published in September 2017

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

scientific article

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2 ⬇️

scientific article published on June 1, 1998

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

scientific article published on 2 March 2018

An acetate switch regulates stress erythropoiesis

scientific article

An adipo-biliary-uridine axis that regulates energy homeostasis

scientific article published on 16 March 2017

Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

scientific article

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

scientific article

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

scientific article published on June 2008

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

scientific article published on December 1998

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

scientific journal article

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

scientific article

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver ⬇️

scientific article published on November 11, 1997

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

scientific article

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver

scientific journal article

Crystal structure of Spot 14, a modulator of fatty acid synthesis ⬇️

scientific article published on October 15, 2010

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

scientific journal article

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

scientific journal article

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

scientific article published on 06 October 2008

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

scientific article

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

scientific article

Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c ⬇️

scientific article published on January 8, 2002

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

scientific article

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

scientific article

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

scientific article published on 26 September 2007

Enhanced fatty acid flux triggered by adiponectin overexpression

scientific article published on November 2011

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.

scientific article published on 28 February 2017

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

scientific article

Genetic and metabolic determinants of plasma PCSK9 levels

scientific article

Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice

scientific article published on 14 January 2014

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

scientific article published on 23 May 2018

Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.

scientific article

Human fatty liver disease: old questions and new insights

scientific article published on June 2011

Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade

scientific article

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

scientific journal article

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

scholarly article

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

scientific article published on November 1999

Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice

scientific article published on 15 January 2018

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

scientific article published on March 1997

Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people

scientific article

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors

scientific article

Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model.

scientific article published on 26 December 2012

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

scientific article

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

scientific article published on 15 February 2016

Molecular basis for LDL receptor recognition by PCSK9

scientific article

Molecular biology of PCSK9: its role in LDL metabolism

scientific article (publication date: February 2007)

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

scientific article

Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy

scientific article published on February 2009

Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver

scientific article published on 01 December 1998

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

scientific article

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

scientific article

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

scientific article

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

scientific article published on October 1996

PCSK9: a convertase that coordinates LDL catabolism

scientific article

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

scientific article published on 19 March 2008

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

scientific article

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

scientific article (publication date: December 2004)

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

scientific article published on 19 March 2012

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice ⬇️

scientific article published on May 26, 1998

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

scientific article

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

scientific article published on 16 July 2019

SREBPs: transcriptional mediators of lipid homeostasis

scientific article

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

scientific journal article

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

scientific article

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

scientific article

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals ⬇️

scientific article published on February 8, 2012

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism ⬇️

scientific article published on December 21, 2012

The impact of endotrophin on the progression of chronic liver disease

scientific article published on 27 October 2020

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

scientific article

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

scientific article published in May 2002

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data

scientific article

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