List of works - Mayland Chang

A chemical biological strategy to facilitate diabetic wound healing.

scientific article published on 26 September 2013

A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition

scientific article published on February 2009

Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy

scientific article

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

scholarly article by Sara Ceballos et al published August 2018 in Antimicrobial Agents and Chemotherapy

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor

scientific article

Combined Scaffold Evaluation and Systems-Level Transcriptome-Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes

scientific article published on 01 July 2019

Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

scientific article published on 18 January 2017

Conformational analyses of thiirane-based gelatinase inhibitors

scientific article published on 5 December 2007

Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.

scientific article published in July 2005

Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

scientific article published on 21 February 2014

Discovery of a potent picolinamide antibacterial active against Clostridioides difficile

scientific article published on 07 August 2020

Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

scientific article

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

scientific article

Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice.

scientific article

Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse

scientific article (publication date: 2015)

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background

scientific article published on August 2008

Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells

scientific article

Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases

scientific article

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases

scientific article

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials

scientific article published on 28 April 2020

Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics

scientific article

Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry

scientific article published on 27 February 2011

Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers

scientific article published on 19 July 2018

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

scientific article published on 16 February 2012

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

scientific article

Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9

scientific article published on 03 December 2019

In Search of Selectivity in Inhibition of ADAM10

scientific article published on 11 June 2018

In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams

scientific article published on 11 July 2016

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.

scientific article

Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor

scientific article published on 01 June 2006

Limitations of Knockout Mice and Other Tools in Assessment of the Involvement of Matrix Metalloproteinases in Wound Healing and the Means to Overcome Them

scientific article published on 24 February 2020

MMP-9 inhibitors impair learning in spontaneously hypertensive rats

scientific article published in PLoS ONE

Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor

scientific article published in March 2008

Metabolism of a highly selective gelatinase inhibitor generates active metabolite

scientific article published on 10 October 2007

Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis

scientific article published on 18 October 2018

Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus

scientific article

O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier

scientific article published on 08 October 2013

Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

scientific article

Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study

scientific article

Potent mechanism-based inhibitors for matrix metalloproteinases

scientific article published on 26 July 2005

Regular and irregular sesquiterpenes containing a halogenated hydropyran from Laurencia caespitosa

scientific article published on 25 July 2002

Restructuring of the extracellular matrix in diabetic wounds and healing: A perspective

scientific article published on 23 March 2016

Role of Matrix Metalloproteinases and Therapeutic Benefits of Their Inhibition in Spinal Cord Injury ⬇️

scientific article published on April 1, 2011

Roles of matrix metalloproteinases in flow-induced outward vascular remodeling

scientific article published on 10 June 2009

Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

scientific article published on 23 August 2016

Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier

scientific article

Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury

scientific article (publication date: 2013)

Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease

scientific article

Selective water-soluble gelatinase inhibitor prodrugs.

scientific article

Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

scientific article

Structure of hydroazulenoid diterpenes from a marine alga and their absolute configuration based on circular dichroism

scientific article published on 12 March 2005

Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors

scientific article

Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

scientific article published on 18 April 2016

Structure-Activity Relationship for the Oxadiazole Class of Antibacterials

scientific article published on 03 October 2019

Structure-activity relationship for the oxadiazole class of antibiotics.

scientific article published on 30 January 2015

Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters

scientific article

Sulfonate-containing thiiranes as selective gelatinase inhibitors

scientific article

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

scientific article published on 20 December 2019

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.

scientific article

Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium

scientific article

Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors

scientific article

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

scientific article published on 21 February 2020

Targeting Extracellular Matrix Remodeling restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma

scientific article published on 20 August 2020

Targeting MMP-9 in Diabetic Foot Ulcers

scientific article published on 22 May 2019

Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain

scientific article published in January 2008

The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus

scientific article

The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity

scientific article published on 6 April 2016

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

scientific article published on 25 April 2019

The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).

scientific article

The haustorium and the chemistry of host recognition in parasitic angiosperms

scientific article (publication date: February 1986)

The oxadiazole antibacterials

scientific article published on 27 May 2016

The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination

scientific article

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials

scientific article published on 12 December 2015

Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing

scientific article published on 27 September 2018

Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury

scientific article published on 4 August 2015

Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier

scientific article published on 30 May 2013

List of works by Mayland Chang

A chemical biological strategy to facilitate diabetic wound healing.

A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition

Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor

Combined Scaffold Evaluation and Systems-Level Transcriptome-Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes

Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

Conformational analyses of thiirane-based gelatinase inhibitors

Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.

Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

Discovery of a potent picolinamide antibacterial active against Clostridioides difficile

Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice.

Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background

Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells

Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials

Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics

Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry

Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9

In Search of Selectivity in Inhibition of ADAM10

In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.

Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor

Limitations of Knockout Mice and Other Tools in Assessment of the Involvement of Matrix Metalloproteinases in Wound Healing and the Means to Overcome Them

MMP-9 inhibitors impair learning in spontaneously hypertensive rats

Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor

Metabolism of a highly selective gelatinase inhibitor generates active metabolite

Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis

Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus

O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier

Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study

Potent mechanism-based inhibitors for matrix metalloproteinases

Regular and irregular sesquiterpenes containing a halogenated hydropyran from Laurencia caespitosa

Restructuring of the extracellular matrix in diabetic wounds and healing: A perspective

Role of Matrix Metalloproteinases and Therapeutic Benefits of Their Inhibition in Spinal Cord Injury ⬇️

Roles of matrix metalloproteinases in flow-induced outward vascular remodeling

Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier

Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury

Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease

Selective water-soluble gelatinase inhibitor prodrugs.

Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

Structure of hydroazulenoid diterpenes from a marine alga and their absolute configuration based on circular dichroism

Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors

Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

Structure-Activity Relationship for the Oxadiazole Class of Antibacterials

Structure-activity relationship for the oxadiazole class of antibiotics.

Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters

Sulfonate-containing thiiranes as selective gelatinase inhibitors

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.

Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium

Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

Targeting Extracellular Matrix Remodeling restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma

Targeting MMP-9 in Diabetic Foot Ulcers

Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain

The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus

The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).

The haustorium and the chemistry of host recognition in parasitic angiosperms

The oxadiazole antibacterials

The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials

Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing

Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury

Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier