List of works by Lanying Du

A 219-mer CHO-expressing receptor-binding domain of SARS-CoV S protein induces potent immune responses and protective immunity

scientific article

A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV

scholarly article by Guangyu Zhao published in September 2018

A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life

article

A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein.

scientific article

A critical HA1 neutralizing domain of H5N1 influenza in an optimal conformation induces strong cross-protection

scientific article

A new role of neuraminidase (NA) in the influenza virus life cycle: implication for developing NA inhibitors with novel mechanism of action

scientific article published on 8 April 2016

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

scientific article published on 25 July 2017

A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC.

scientific article

A recombinant protein containing highly conserved hemagglutinin residues 81-122 of influenza H5N1 induces strong humoral and mucosal immune responses

scientific article published on June 2013

A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection

scientific article

A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses

scientific article

A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV

scientific article published on 26 August 2013

A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines

scientific article

ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer

scientific article published on 3 January 2014

Adenovirus-based vaccines against avian-origin H5N1 influenza viruses.

scientific article

Advancements in the development of subunit influenza vaccines

scientific article

Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain

scientific article published in 2019

Advances in the research and development of therapeutic antibodies against the Zika virus.

scientific article published on 25 May 2018

An H5N1 M2e-based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus

scientific article

An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses.

scientific article

Anti-HIV antibody and drug combinations exhibit synergistic activity against drug-resistant HIV-1 strains

scientific article

Antibodies induced by receptor-binding domain in spike protein of SARS-CoV do not cross-neutralize the novel human coronavirus hCoV-EMC.

scientific article

Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cells

scientific article published on 05 May 2009

Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocket

scientific article published on 11 January 2013

Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV.

scientific article published on 24 April 2018

CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry

scientific article published on 22 April 2011

Calling for rapid development of a safe and effective MERS vaccine.

scientific article published on 12 June 2014

Cell Entry of Porcine Epidemic Diarrhea Coronavirus Is Activated by Lysosomal Proteases.

scientific article published on 11 October 2016

Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

scientific article

Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity

scientific article published on 22 May 2007

Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice

scientific article published on 02 March 2017

Complement inhibition alleviates paraquat-induced acute lung injury

scientific article

Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses

scientific article published on 24 January 2018

Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses.

scientific article published on 10 November 2017

Current advancements and potential strategies in the development of MERS-CoV vaccines

scientific article

Development of SARS vaccines and therapeutics is still needed

article

Development of a heat-stable and orally delivered recombinant M2e-expressing B. subtilis spore-based influenza vaccine

scientific article published in January 2014

Development of a safe and convenient neutralization assay for rapid screening of influenza HA-specific neutralizing monoclonal antibodies

scientific article published on July 2010

Development of subunit vaccines against severe acute respiratory syndrome

scientific article published on January 2008

Differences in the pathogenicity and inflammatory responses induced by avian influenza A/H7N9 virus infection in BALB/c and C57BL/6 mouse models

scientific article

Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen.

scientific article published on 26 February 2018

Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain

scholarly article by Lei He et al published 19 February 2019 in Viruses

Evaluation of recombinant Onchocerca volvulus activation associated protein-1 (ASP-1) as a potent Th1-biased adjuvant with a panel of protein or peptide-based antigens and commercial inactivated vaccines

scientific article published on 19 August 2008

Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.

scientific article

HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

scientific article published on 21 June 2017

Highly pathogenic avian influenza A(H5N1) mutants transmissible by air are susceptible to human and animal neutralizing antibodies

scientific article published on 18 July 2013

Identification and characterization of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: revealing the critical antigenic determinants in inactivated SARS-CoV vaccine.

scientific article published on 11 May 2006

Identification and structural characterization of a broadly neutralizing antibody targeting a novel conserved epitope on the influenza virus H5N1 hemagglutinin

scientific article

Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development

scientific article

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus.

scientific article

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

scientific article

In silico design of a DNA-based HIV-1 multi-epitope vaccine for Chinese populations

scientific article published in January 2015

Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant ⬇️

scientific article published on August 21, 2010

Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection

scientific article published in August 2013

Intranasal administration of maleic anhydride-modified human serum albumin for pre-exposure prophylaxis of respiratory syncytial virus infection

scientific article

Intranasal vaccination of recombinant H5N1 HA1 proteins fused with foldon and Fc induces strong mucosal immune responses with neutralizing activity: Implication for developing novel mucosal influenza vaccines

scientific article published on 11 August 2015

Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against

scientific article published on January 2008

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines.

scientific article

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

scientific article

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody.

scientific article

MERS-CoV spike protein: a key target for antivirals

scientific article

Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China

scientific article published on 01 February 2020

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein.

scientific article

Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread

scientific article

Middle East respiratory syndrome: current status and future prospects for vaccine development

scientific article published on 28 September 2015

Modulation of HBV replication by microRNA-15b through targeting hepatocyte nuclear factor 1α

scientific article

Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

scientific article published on 23 December 2015

Nelfinavir, an HIV protease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mitochondrial pathway

scientific article published on 29 April 2015

Optimization of antigen dose for a receptor-binding domain-based subunit vaccine against MERS coronavirus

scientific article published in January 2015

Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients ⬇️

scientific article published on November 4, 2010

Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses

scientific article

Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection.

scientific article published on 04 February 2008

Prospects for a MERS-CoV spike vaccine

scientific article published on 09 August 2018

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

scientific article

Protocol for recombinant RBD-based SARS vaccines: protein preparation, animal vaccination and neutralization detection

scientific article

Putative conformations of the receptor-binding domain in S protein of hCoV-EMC in complex with its receptor dipeptidyl peptidase-4.

scientific article

Recent advances in the detection of respiratory virus infection in humans

article published 15 January 2020

Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

scientific article

Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

scientific article published on 18 March 2015

Receptor-binding domain as a target for developing SARS vaccines.

scientific article

Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transgenic mice from MERS-CoV infection

scientific article

Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model

scientific article published on 30 October 2006

Receptor-binding domain-based subunit vaccines against MERS-CoV

scientific article

Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines.

scientific article published on 8 August 2012

Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

scientific article published on 19 October 2016

Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits neutralizing antibodies: Implication for developing SARS vaccines

scientific article published on 21 June 2006

Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity

scientific article published on 15 August 2009

Research and development of universal influenza vaccines

scientific article

Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome

scientific article published on December 2012

Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines

scientific article published on April 2010

Salmonella typhi Ty21a bacterial ghost vector augments HIV-1 gp140 DNA vaccine-induced peripheral and mucosal antibody responses via TLR4 pathway

scientific article

Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments--the importance of immunofocusing in subunit vaccine design

scientific article

Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release

scholarly article

Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection

scientific article published on 13 June 2016

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

scientific article

Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus

scientific article

Testing of Middle East respiratory syndrome coronavirus replication inhibitors for the ability to block viral entry

scientific article published on 20 October 2014

The adjuvanticity of an O. volvulus-derived rOv-ASP-1 protein in mice using sequential vaccinations and in non-human primates

scientific article (publication date: 2012)

The latest advancements in Zika virus vaccine development

scientific article published on 07 August 2017

The spike protein of SARS-CoV--a target for vaccine and therapeutic development

scientific article

Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise

scientific article published in 2019

Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application

scientific article published on 2 January 2018

Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus

scientific article published on 10 June 2015

Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin

scientific article published on October 2015

Vaccines for the prevention against the threat of MERS-CoV.

scientific article published on 17 March 2016

Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

scientific article

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