List of works - Christopher J A Pugh

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

scientific article published in August 2003

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

scientific article published in April 2003

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation

scientific article

Carotid artery wall mechanics in young males with high cardiorespiratory fitness

scientific article published on 01 August 2018

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

scientific article published on 20 May 2013

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

scientific article

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

scientific article

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

scientific article

Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease

scientific article

Ectopic lipid storage in non-alcoholic fatty liver disease is not mediated by impaired mitochondrial oxidative capacity in skeletal muscle

article

Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition

scientific article published in January 2014

Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease

scientific article

Exercise training in polycystic ovarian syndrome enhances flow-mediated dilation in the absence of changes in fatness

scientific article published in December 2013

Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease

scientific article published on November 2014

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

scientific journal article

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

scientific article

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma

article

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

scientific article (publication date: July 2006)

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

scientific article

Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance.

scientific article published on 26 July 2012

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex

scientific article

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

scientific article published on 21 October 2010

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

scientific article

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

scientific article

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

scientific article

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

scientific article published on 03 December 2019

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

scientific article

The influence of habitual endurance exercise on carotid artery strain and strain-rate in young and middle-aged men

scientific article published on 24 June 2020

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

scientific article

List of works by Christopher J A Pugh

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation

Carotid artery wall mechanics in young males with high cardiorespiratory fitness

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease

Ectopic lipid storage in non-alcoholic fatty liver disease is not mediated by impaired mitochondrial oxidative capacity in skeletal muscle

Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition

Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease

Exercise training in polycystic ovarian syndrome enhances flow-mediated dilation in the absence of changes in fatness

Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance.

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

The influence of habitual endurance exercise on carotid artery strain and strain-rate in young and middle-aged men

The use of dioxygen by HIF prolyl hydroxylase (PHD1)