List of works - Kevin Wiehe

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

scientific article published on 26 January 2022

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

scientific article published on 19 March 2018

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

scientific article published on 10 March 2014

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved

scientific article

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

scientific article published on 01 January 2019

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

scientific article

Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency

scientific article published on 31 January 2020

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

scientific article

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 02 December 2019

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

scientific article published on 24 January 2020

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

scientific article

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.

scientific article published on 31 May 2018

HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces Gp41 Antibody Immunodominance in Rhesus Macaques

scientific article published on 09 August 2017

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.

scientific article published on 16 March 2018

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

scientific article published on 30 January 2020

HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies

scientific article

HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

scientific article published on 30 July 2015

HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria

scientific article

HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers

scientific article published on 15 July 2019

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria

scientific article

Immune checkpoint modulation enhances HIV-1 antibody induction

scientific article published on 19 February 2020

Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice

scientific article published on 23 December 2016

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

article

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations ⬇️

scientific article published on 23 November 2017

Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages

scientific article published on April 2016

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

scientific article published on 10 March 2020

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

scientific article published on March 2017

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

scientific article published on 28 March 2022

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 17 September 2019

Polyreactivity and autoreactivity among HIV-1 antibodies

scientific article

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

scientific article published on January 2017

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

scientific article published on 19 November 2020

Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

scientific article

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

scientific article published in Nature Communications

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

scientific article published on 03 September 2019

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

scientific article published on March 2017

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

scientific article published on 20 June 2015

Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s

scientific article published on 06 January 2022

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

scientific article

Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques

scientific article published on 08 December 2016

V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity

article

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

scientific article

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

scientific article

List of works by Kevin Wiehe

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.

HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces Gp41 Antibody Immunodominance in Rhesus Macaques

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies

HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria

HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria

Immune checkpoint modulation enhances HIV-1 antibody induction

Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations ⬇️

Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

Polyreactivity and autoreactivity among HIV-1 antibodies

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques

V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2