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List of works by Gregg B Fields

A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis

scientific article

A Novel Probe for Spliceosomal Proteins that Induces Autophagy and Death of Melanoma Cells Reveals New Targets for Melanoma Drug Discovery

scientific article published on 01 January 2019

A PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth

scientific article

A Peptide mimicking a region in proliferating cell nuclear antigen specific to key protein interactions is cytotoxic to breast cancer

scientific article

A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold

scientific article

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates

scientific article published on 18 June 2013

AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α.

scientific article

Amino acid residue Val362 plays a critical role in maintaining the structure of C terminus of connexin 50 and in lens epithelial-fiber differentiation

scientific article

Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates

scientific article published on 28 September 2009

Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids

scientific article published on 01 October 2003

Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly

scientific article

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

scientific article

Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems ⬇️

scientific article published on November 14, 2012

Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors

scientific article

Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.

scientific article published on 13 July 2016

Biophysical studies of matrix metalloproteinase/triple-helix complexes

scientific article

Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities ⬇️

scientific article published on February 1, 2004

Characterization and regulation of MT1-MMP cell surface-associated activity.

scientific article published on 27 November 2018

Characterization of Peptide−Amphiphiles Possessing Cellular Activation Sequences ⬇️

scientific article published on May 1, 2003

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

scientific article

Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

scientific article

Chemical Biology for Understanding Matrix Metalloproteinase Function ⬇️

scientific article published on August 30, 2012

Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle.

scientific article

Clinical implications of compounds designed to inhibit ECM-modifying metalloproteinases.

scientific article published on 14 June 2017

Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

scientific article published on 15 July 2004

Collagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical Substrates

scientific article

Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies

scientific article published on 08 May 2017

Comparative proteomic analysis of matched primary and metastatic melanoma cell lines

scientific article

Comparison of metalloproteinase protein and activity profiling ⬇️

scientific article published on October 23, 2010

Conformational Dynamics of Matrix Metalloproteinase-1·Triple-Helical Peptide Complexes.

scientific article published on 21 November 2017

Contributions of the MMP-2 collagen binding domain to gelatin cleavage. Substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides

scientific article published on June 2004

Correction to Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis

scientific article published on 03 November 2020

Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site

scientific article published on 18 September 2011

Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe

scientific article

Determination of penetratin secondary structure in live cells with Raman microscopy

scientific article

Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates

scientific article published on January 2017

Development of a Förster resonance energy transfer assay for monitoring bacterial collagenase triple-helical peptidase activity

scientific article

Development of a convenient peptide-based assay for lysyl hydroxylase

scientific article

Development of a solid-phase assay for analysis of matrix metalloproteinase activity.

scientific article published on December 2004

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.

scientific article

Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study

scientific article published on 20 August 2018

Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.

scientific article

Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences

scientific article published on 06 March 2007

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

scientific article

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

scientific article

Dissecting MMP P' and P' subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library

scientific article published in Journal of Biological Chemistry

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

scientific article published on 13 October 2016

Editorial

Effects of Mutations on Structure-Function Relationships of Matrix Metalloproteinase-1.

scientific article published on 14 October 2016

Effects of drug hydrophobicity on liposomal stability

scientific article

Efficient synthesis of Fmoc-protected phosphinic pseudodipeptides: Building blocks for the synthesis of matrix metalloproteinase inhibitors

scientific article published on January 2011

Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor

scientific article published on 29 December 2006

Engineered sarafotoxins as tissue inhibitor of metalloproteinases-like matrix metalloproteinase inhibitors

scientific article

Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state

scientific article

Evaluation of a triple-helical peptide with quenched FluorSophores for optical imaging of MMP-2 and MMP-9 proteolytic activity

scientific article

Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state.

scientific article published on 11 September 2013

Exosite Interactions Impact Matrix Metalloproteinase Collagen Specificities ⬇️

scientific article published on September 6, 2011

Extracellular proteases as targets for drug development

scientific article

Glycosylation modulates melanoma cell α2β1 and α3β1 integrin interactions with type IV collagen

scientific article

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition

scientific article

Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia

scientific article published on 09 March 2020

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

scientific article

Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2) ⬇️

scientific article published on September 1, 2012

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

scientific article published on 22 September 2011

Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

scientific article published on July 2009

Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression

scientific article published on January 2016

Importance of the Linker Region in Matrix Metalloproteinase-1 Domain Interactions

scientific article published on January 2016

Induction of endothelial cell activation by a triple helical alpha2beta integrin ligand, derived from type I collagen alpha1(I)496-507.

scientific article published on 26 October 2003

Interstitial collagen catabolism

scientific article published on 19 February 2013

Introduction to Peptide Synthesis

scientific article published on 01 August 2002

Introduction to peptide synthesis

scientific article

Introduction to peptide synthesis

scientific article published on 01 May 2002

Introduction to peptide synthesis

scientific article published on 01 August 2012

LETTER FROM THE EDITOR

article published in 2004

Lips symposia in print and other issues

Local conformation and dynamics of isoleucine in the collagenase cleavage site provide a recognition signal for matrix metalloproteinases.

scientific article

Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.

scientific article

MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity

scientific article published on 6 June 2008

MT1-MMP Binds Membranes by Opposite Tips of Its β Propeller to Position It for Pericellular Proteolysis

scientific article published on 21 November 2018

Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability

scientific article published on 16 December 2020

Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11

scientific article published on 28 November 2019

Matrix metalloproteinase collagenolysis in health and disease

scientific article published on 26 April 2017

Matrix metalloproteinase inhibition by heterotrimeric triple-helical Peptide transition state analogues

scientific article published on 12 March 2015

Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability

scientific article published on 01 September 2004

Matrix metalloproteinases and collagen catabolism

scientific article

Matrix metalloproteinases as reagents for cell isolation.

scientific article published on 20 July 2016

Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases.

scientific article published on 4 June 2019

Melanoma cell CD44 interaction with the alpha 1(IV)1263-1277 region from basement membrane collagen is modulated by ligand glycosylation

scientific article

Methods for the Construction of Collagen-Based Triple-Helical Peptides Designed as Matrix Metalloproteinase Inhibitors

scientific article published on 01 January 2019

Modulation of receptor binding to collagen by glycosylated 5-hydroxylysine: Chemical biology approaches made feasible by Carpino's Fmoc group

scientific article published on 19 March 2020

Modulation of triple-helical stability and subsequent melanoma cellular responses by single-site substitution of fluoroproline derivatives

scientific article

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

scientific article published on 17 February 2014

NMR and Bioinformatics Discovery of Exosites That Tune Metalloelastase Specificity for Solubilized Elastin and Collagen Triple Helices ⬇️

scientific article published on July 27, 2010

Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo

scientific article

New strategies for targeting matrix metalloproteinases

scientific article published on 14 January 2015

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis

scientific article published on 05 February 2014

Parallel problems: Applying institutional corruption analysis of Congress to big pharma

scientific article

Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12.

scientific article

Peptide-based selective inhibitors of matrix metalloproteinase-mediated activities

scientific article published on 30 November 2012

Peptide-mediated targeting of liposomes to tumor cells

scientific article published in January 2007

Polypeptide chains containing D-gamma-hydroxyvaline

scientific article

Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

scientific article published on 15 July 2015

Proteolytic profiling of the extracellular matrix degradome

scientific article

Rapid lead discovery through iterative screening of one bead one compound libraries

scientific article

Regenerative Medicine in the State of Florida: Letter Outlining the Florida Organization for Regenerative Medicine

scientific article published on 01 July 2018

Regulation of collagenase activities of human cathepsins by glycosaminoglycans

scientific article

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

scientific article

Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate

scientific article

Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.

scientific article published on 10 April 2017

Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9

scientific article published on 17 March 2003

Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition

scientific article published on 22 May 2008

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases ⬇️

scientific article published on March 21, 2013

Solid-phase synthesis, characterization, and cellular activities of collagen-model nanodiamond-peptide conjugates

scientific article published in May 2015

Stabilization of collagen-model, triple-helical peptides for in vitro and in vivo applications

scientific article published on January 2013

Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis

scientific article

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.

scientific article published on 27 June 2017

Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

scientific article

Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide

scientific article published on 16 November 2017

Synthesis and biological applications of collagen-model triple-helical peptides

scientific article published on 20 January 2010

Synthesis and solid-phase application of suitably protected gamma-hydroxyvaline building blocks

scientific article published on 21 June 2007

Synthesis and solid-phase application of suitably protected gamma-hydroxyvaline building blocks.

scientific article published in January 2009

Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building Blocks

scientific article published on December 2012

TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution

scientific article published on 01 October 2020

Targeted drug delivery utilizing protein-like molecular architecture

scientific article published on 31 March 2007

The Expanding Role of MT1-MMP in Cancer Progression

scientific article published on 20 May 2019

The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells

scientific article

The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma

scientific article published on 26 July 2018

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

scientific article published on 27 August 2019

The Roles of Matrix Metalloproteinases in Pancreatic Cancer

scientific article published on 18 April 2017

The history of matrix metalloproteinases: milestones, myths, and misperceptions ⬇️

scientific article published on August 17, 2012

The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite.

scientific article published on 26 October 2011

The normalization of gene expression data in melanoma: investigating the use of glyceraldehyde 3-phosphate dehydrogenase and 18S ribosomal RNA as internal reference genes for quantitative real-time PCR.

scientific article

The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.

scientific article published on 02 December 2013

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

scientific article published on 25 October 2006

The synthesis and application of Fmoc‐Lys(5‐Fam) building blocks ⬇️

scientific article published on July 1, 2013

Transient collagen triple helix binding to a key metalloproteinase in invasion and development.

scientific article published on February 2015

Tricine as a convenient scaffold for the synthesis of C-terminally branched collagen-model peptides

scientific article published on 5 December 2017

Triple-helical peptide analysis of collagenolytic protease activity

scientific article

Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors

scientific article published on 2 August 2007

Using fluorogenic peptide substrates to assay matrix metalloproteinases

Variability in melanoma metalloproteinase expression profiling

scientific article

δ/ω-Plectoxin-Pt1a: An Excitatory Spider Toxin with Actions on both Ca2+ and Na+ Channels ⬇️

scientific article published on May 14, 2013

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