List of works - Sandro Santagata

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

scientific article

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

scientific article published on 26 September 2015

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

scientific article

Profiling critical cancer gene mutations in clinical tumor samples

scientific article

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

scientific article published on 20 January 2013

JAGGED1 expression is associated with prostate cancer metastasis and recurrence

scientific article

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

scientific article

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications

scientific article

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

scientific article published on 31 October 2011

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

scientific article

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy

scientific article

Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy

scientific article

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

scientific article published on 30 April 2013

Taxonomy of breast cancer based on normal cell phenotype predicts outcome.

scientific article published on 27 January 2014

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

scientific article

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

scientific article published on 30 June 2013

Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors.

scientific article published on June 2007

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

scientific article

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

scientific article published on 28 January 2016

Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02

scientific article published on 26 January 2014

Using the heat-shock response to discover anticancer compounds that target protein homeostasis

scientific article published on 30 November 2011

Phase II study of protracted daily temozolomide for low-grade gliomas in adults

scientific article

Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis

scientific article

Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.

scientific article published on 23 October 2015

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

scientific article

Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging

scientific article

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

scientific article

Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma

scientific article published on March 2015

Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy

scientific article published on 4 August 2014

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

scientific article

Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.

scientific article published on 30 August 2011

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

scientific article published on 11 July 2018

Inhibiting HSP90 to Treat Cancer: A Strategy in Evolution

scientific article published on November 1, 2012

Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.

scientific article published on 12 April 2016

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

scientific article published on September 2014

Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma

scientific article

ARID1A and TERT promoter mutations in dedifferentiated meningioma

scientific article published on 18 March 2015

The Effect of Me2+ Cofactors at the Initial Stages of V(D)J Recombination

scientific article published on June 26, 1998

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma

scientific article

Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia

scientific article published on 21 November 2014

A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma

scientific article

Mass spectrometry imaging as a tool for surgical decision-making

scientific article

Genomic landscape of high-grade meningiomas.

scientific article published on 26 April 2017

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

scientific article

Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas

scientific article published on 9 November 2016

Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG

scientific article

DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues

scientific article

Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors

scientific article published on 15 September 2016

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

scientific article published on 19 January 2017

Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide

scientific article published on 01 December 2018

List of works by Sandro Santagata

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

Profiling critical cancer gene mutations in clinical tumor samples

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

JAGGED1 expression is associated with prostate cancer metastasis and recurrence

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy

Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

Taxonomy of breast cancer based on normal cell phenotype predicts outcome.

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors.

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02

Using the heat-shock response to discover anticancer compounds that target protein homeostasis

Phase II study of protracted daily temozolomide for low-grade gliomas in adults

Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis

Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma

Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

Inhibiting HSP90 to Treat Cancer: A Strategy in Evolution

Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma

ARID1A and TERT promoter mutations in dedifferentiated meningioma

The Effect of Me2+ Cofactors at the Initial Stages of V(D)J Recombination

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma

Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia

A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma

Mass spectrometry imaging as a tool for surgical decision-making

Genomic landscape of high-grade meningiomas.

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas

Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG

DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues

Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide