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List of works by William R Schief

A Blueprint for HIV Vaccine Discovery

scientific article

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

scientific article

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

scientific article

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

scientific article published on July 2016

A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses

scientific article

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

scientific article published on 31 October 2019

Advances in structure-based vaccine design ⬇️

scientific article published on June 25, 2013

An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells

scientific article

Anti-HIV B Cell lines as candidate vaccine biosensors

scientific article published on 12 October 2012

Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity

scientific article published on 01 May 2020

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

scientific article published on 07 December 2020

Automatically Fixing Errors in Glycoprotein Structures with Rosetta

scientific article published on 18 October 2018

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

scientific article published on 01 September 2020

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates

scientific article published on 12 August 2013

Better together: Elements of successful scientific software development in a distributed collaborative community

scientific article published on 04 May 2020

Challenges for structure-based HIV vaccine design

scientific article published on September 2009

CoV3D: A database of high resolution coronavirus protein structures

scientific article published on 14 May 2020

CoV3D: a database of high resolution coronavirus protein structures

scientific article published on 05 September 2020

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial

scientific article

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

scientific article

Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design ⬇️

scientific article published on October 20, 2010

Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope

scientific article

Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope

scientific article

Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5.

scientific article published on 31 July 2014

Correction for Ingale et al., Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

scientific article published on June 2015

Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

scientific article published on 14 September 2016

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

scientific article

Design and Characterization of Stabilized Derivatives of Human CD4D12 and CD4D1

article

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

scientific article published in Nature Communications

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction

scientific article

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

scientific article

Elicitation of structure-specific antibodies by epitope scaffolds

scientific article

Engineered immunogen binding to alum adjuvant enhances humoral immunity

scientific article published on 17 February 2020

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

scientific article published on 25 March 2013

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

scientific article published in Scientific Reports

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination

scientific article published on 29 July 2019

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

scientific article published on 29 November 2021

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein

scientific article published on 03 March 2014

Expression of complete SIV p27 Gag and HIV gp120 engineered outer domains targeted by broadly neutralizing antibodies in live rubella vectors

scientific article published on 5 May 2017

From structure to sequence: Antibody discovery using cryoEM

scientific article published on 19 January 2022

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

scientific article published on 31 July 2018

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

scientific article

Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development

scientific article

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

scientific article published on 2 May 2018

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

scientific article published on 07 September 2016

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

scientific article published on 01 April 2020

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

scientific article

HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

scientific article

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

scientific article

Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant

scientific article

High-resolution structure prediction of a circular permutation loop

scientific article

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

scientific article published on 17 August 2016

Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

scientific article

Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10 ⬇️

scientific article published on August 12, 2013

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

scientific article

Immunogenicity of HIV-1 envelope glycoprotein oligomers

scientific article published on September 2009

Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

scientific article published on 19 August 2019

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

scientific article

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

scientific article published on September 2016

Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism.

scholarly article

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

scientific article published on 20 December 2018

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.

scientific article

Liquid-crystalline collapse of pulmonary surfactant monolayers

scientific article

Macromolecular modeling and design in Rosetta: recent methods and frameworks

scientific article published on 01 June 2020

Mapping a common interaction site used by Plasmodium falciparum Duffy binding-like domains to bind diverse host receptors

scientific article

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

scientific article

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

scientific article published on 01 February 2021

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

scientific article published on 16 November 2017

Molecular motors: single-molecule recordings made easy.

scientific article

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

scientific article published on 21 August 2020

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors

scientific article published on 01 December 2020

Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation

scientific article published on 03 September 2013

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

scientific article published on 24 September 2019

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

scientific article published on 26 December 2017

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

scientific article published on 8 September 2016

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

scientific article published on May 2014

Proof of principle for epitope-focused vaccine design

scientific article

PyRosetta Jupyter Notebooks Teach Biomolecular Structure Prediction and Design

scientific article published on 16 April 2021

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization ⬇️

scientific article published on 01 November 2019

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan

scientific article published on 01 July 2019

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

scientific article

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

scientific article (publication date: 13 August 2010)

Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections

scientific article

Refocussing Antibody Responses by Chemical Modification of Vaccine Antigens

article

Residue-centric modeling and design of saccharide and glycoconjugate structures

scientific article

Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency

scientific article

Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization

scientific article published on 24 March 2010

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

scientific article published on 29 June 2020

Rosetta predictions in CASP5: successes, failures, and prospects for complete automation.

scientific article

RosettaAntibodyDesign (RAbD): A General Framework for Computational Antibody Design

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design

scientific article published on 27 April 2018

RosettaRemodel: a generalized framework for flexible backbone protein design.

scientific article

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

scientific article published on September 2016

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

scientific article published on 09 May 2019

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

scientific article published on 01 January 2020

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.

scientific article published on 24 February 2016

Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein

scientific article published on 17 October 2016

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

scientific article

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

scientific article published on September 2016

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

scientific article published on 05 August 2020

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

article

Vaccination induces HIV broadly neutralizing antibody precursors in humans ⬇️

journal article published in 2022

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

scientific article published on 17 November 2020

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells

scientific article published on 06 September 2021

Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates

scientific article published in 2024

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

scientific article

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

scholarly article by Matthias G Pauthner et al published 15 January 2019 in Immunity

When designing vaccines, consider the starting material: the human B cell repertoire

scholarly article by Colin Havenar-Daughton et al published 1 August 2018 in Current Opinion in Immunology

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