List of works - Richard K Plemper

A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

scientific article published on 21 December 2020

A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion

scientific article published on 21 August 2013

A target site for template-based design of measles virus entry inhibitors.

scholarly article

Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus

scientific article published on 10 April 2020

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

scientific article

Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)

scientific article published in 2023

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

scientific article published on 30 January 2013

Atypical fusion peptide of Nelson Bay virus fusion-associated small transmembrane protein

scientific article

Biology must develop herd immunity against bad-actor molecules.

scientific article published on 28 June 2018

Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics

scientific article published on 05 August 2019

Blocking Respiratory Syncytial Virus Entry: A Story with Twists

scientific article published on 11 May 2015

Blue native PAGE and biomolecular complementation reveal a tetrameric or higher-order oligomer organization of the physiological measles virus attachment protein H.

scientific article published on 22 September 2010

Cancer and virus leads by HTS, chemical design and SEA data mining

scientific article published in January 2009

Canine distemper virus envelope protein interactions modulated by hydrophobic residues in the fusion protein globular head

scientific article

Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications

scientific article published on 26 November 2013

Cell entry of enveloped viruses

scientific article

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

scientific article published on 01 October 2019

Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors

scientific article

Design of a small-molecule entry inhibitor with activity against primary measles virus strains

scientific article

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression

scientific article

Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain

scientific article

Envelope protein dynamics in paramyxovirus entry

scientific article published on 02 July 2013

Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein

scientific article

High-throughput screening-based identification of paramyxovirus inhibitors

scientific article

Host-directed Inhibitors of Myxoviruses: Synthesis and in vitro Biochemical Evaluation

scientific article published on August 2011

Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening

scientific article

Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex

scientific article

Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis

scientific article

Independent structural domains in paramyxovirus polymerase protein

scientific article published on 3 January 2012

Measles control--can measles virus inhibitors make a difference?

scientific article published on August 2009

Measles virus entry inhibitors: a structural proposal for mechanism of action and the development of resistance

scientific article

Measles virus glycoprotein complexes preassemble intracellularly and relax during transport to the cell surface in preparation for fusion

scientific article

Mechanism for active membrane fusion triggering by morbillivirus attachment protein

scientific article published on 17 October 2012

Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virus

scientific article published on 26 December 2013

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

scientific article

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics

scientific article

Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity

scientific article

Nonpeptide inhibitors of measles virus entry

scientific article published on August 2006

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity

scientific article

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

scientific article published on 05 November 2021

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

scientific article published on 27 July 2018

Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase

scientific article published on 13 July 2020

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex

scientific article (publication date: 10 September 2016)

Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases

scientific article

Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex

scientific article published on 05 June 2008

Primary Resistance Mechanism of the Canine Distemper Virus Fusion Protein against a Small-Molecule Membrane Fusion Inhibitor

scientific article published on 05 October 2018

Probing the spatial organization of measles virus fusion complexes

scientific article published on 5 August 2009

Promotion of virus assembly and organization by the measles virus matrix protein.

scientific article published on 30 April 2018

Protein degradation in human disease.

scientific article

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

scientific article published on 25 December 2019

Recombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease

scientific article

Releasing the genomic RNA sequestered in the mumps virus nucleocapsid

scientific article published on 31 August 2016

Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens

scientific article published on 26 August 2015

Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process

scientific article (publication date: May 2015)

Structural and mechanistic studies of measles virus illuminate paramyxovirus entry

scientific article

Structural rearrangements of the central region of the morbillivirus attachment protein stalk domain trigger F protein refolding for membrane fusion

scientific article

Structure of the primed paramyxovirus fusion protein

scientific article

Synergizing vaccinations with therapeutics for measles eradication

scientific article

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy

scientific article published on August 2013

Systematic approaches towards the development of host-directed antiviral therapeutics

scientific article

Target analysis of the experimental measles therapeutic AS-136A

scientific article

The Near-to-Native-State Architecture of Measles Virus Assembly Sites and Isolated Measles Virus Particles

scholarly article by Elizabeth R. Wright et al published July 2017 in Microscopy and Microanalysis

The impact of high-resolution structural data on stemming the COVID-19 pandemic

scientific article published in 2021

The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity.

scientific article published on 03 September 2013

The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope

scientific article published on 2 January 2013

The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection

scientific article published on 10 July 2013

The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient

scientific article published on 03 February 2017

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

scientific article published on 03 December 2020

Triggering the measles virus membrane fusion machinery

scientific article

Tunable and reversible drug control of protein production via a self-excising degron.

scientific article

Two domains that control prefusion stability and transport competence of the measles virus fusion protein

scientific article published on February 2006

Viral evolution identifies a regulatory interface between paramyxovirus polymerase complex and nucleocapsid that controls replication dynamics

scientific article published on 04 March 2020

List of works by Richard K Plemper

A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion

A target site for template-based design of measles virus entry inhibitors.

Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

Atypical fusion peptide of Nelson Bay virus fusion-associated small transmembrane protein

Biology must develop herd immunity against bad-actor molecules.

Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics

Blocking Respiratory Syncytial Virus Entry: A Story with Twists

Blue native PAGE and biomolecular complementation reveal a tetrameric or higher-order oligomer organization of the physiological measles virus attachment protein H.

Cancer and virus leads by HTS, chemical design and SEA data mining

Canine distemper virus envelope protein interactions modulated by hydrophobic residues in the fusion protein globular head

Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications

Cell entry of enveloped viruses

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors

Design of a small-molecule entry inhibitor with activity against primary measles virus strains

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression

Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain

Envelope protein dynamics in paramyxovirus entry

Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein

High-throughput screening-based identification of paramyxovirus inhibitors

Host-directed Inhibitors of Myxoviruses: Synthesis and in vitro Biochemical Evaluation

Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening

Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex

Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis

Independent structural domains in paramyxovirus polymerase protein

Measles control--can measles virus inhibitors make a difference?

Measles virus entry inhibitors: a structural proposal for mechanism of action and the development of resistance

Measles virus glycoprotein complexes preassemble intracellularly and relax during transport to the cell surface in preparation for fusion

Mechanism for active membrane fusion triggering by morbillivirus attachment protein

Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virus

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics

Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity

Nonpeptide inhibitors of measles virus entry

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex

Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases

Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex

Primary Resistance Mechanism of the Canine Distemper Virus Fusion Protein against a Small-Molecule Membrane Fusion Inhibitor

Probing the spatial organization of measles virus fusion complexes

Promotion of virus assembly and organization by the measles virus matrix protein.

Protein degradation in human disease.

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

Recombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease

Releasing the genomic RNA sequestered in the mumps virus nucleocapsid

Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens

Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process

Structural and mechanistic studies of measles virus illuminate paramyxovirus entry

Structural rearrangements of the central region of the morbillivirus attachment protein stalk domain trigger F protein refolding for membrane fusion

Structure of the primed paramyxovirus fusion protein

Synergizing vaccinations with therapeutics for measles eradication

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy

Systematic approaches towards the development of host-directed antiviral therapeutics

Target analysis of the experimental measles therapeutic AS-136A

The Near-to-Native-State Architecture of Measles Virus Assembly Sites and Isolated Measles Virus Particles

The impact of high-resolution structural data on stemming the COVID-19 pandemic

The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity.

The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope

The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection

The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

Triggering the measles virus membrane fusion machinery

Tunable and reversible drug control of protein production via a self-excising degron.

Two domains that control prefusion stability and transport competence of the measles virus fusion protein

Viral evolution identifies a regulatory interface between paramyxovirus polymerase complex and nucleocapsid that controls replication dynamics