List of works - Janet R Kumita

A FRET sensor for non-invasive imaging of amyloid formation in vivo

scientific article

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

scientific article

A Water-Soluble Azobenzene Cross-Linker for Photocontrol of Peptide Conformation

scientific article published on 01 July 2003

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

scientific article published on 9 April 2010

A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis

scientific article published on 26 August 2020

ANS binding reveals common features of cytotoxic amyloid species

scientific article published in August 2010

Achieving photo-control of protein conformation and activity: producing a photo-controlled leucine zipper.

scientific article

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies

scientific article published on 23 June 2015

Alpha-helix formation in a photoswitchable peptide tracked from picoseconds to microseconds by time-resolved IR spectroscopy.

scientific article

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

scientific article published on 11 May 2017

Analysis of the native structure, stability and aggregation of biotinylated human lysozyme

scientific article

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.

scientific article

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation

scientific article published on 11 January 2019

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

scientific article published on 07 May 2018

Clusterin protects neurons against intracellular proteotoxicity

scientific article published on 7 November 2017

Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster

scientific article published on 29 September 2011

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

scientific article published on 10 June 2011

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils

scientific article published on 25 September 2008

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

scientific article

Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin

scientific article

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

scientific article published on 23 February 2017

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

scientific article published on 18 February 2014

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution

scientific article

Methods and models in neurodegenerative and systemic protein aggregation diseases

scientific article published on January 2010

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

scientific article published in May 2008

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

scientific article published on 5 September 2014

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

scientific article

Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes.

scientific article published in October 2006

Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants.

scientific article

Origins of helix-coil switching in a light-sensitive peptide.

scientific article published in December 2004

Photo-control of peptide helix content by an azobenzene cross-linker: steric interactions with underlying residues are not critical

scientific article published in July 2002

Population of nonnative states of lysozyme variants drives amyloid fibril formation

scientific article published on 29 April 2011

Prevention of peptide fibril formation in an aqueous environment by mutation of a single residue to Aib.

scientific article published in April 2003

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

scientific article

Protein amyloids develop an intrinsic fluorescence signature during aggregation

scientific article

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

scientific article published on 20 October 2020

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

scientific article published on 25 June 2020

Reversible photocontrol of DNA binding by a designed GCN4-bZIP protein

scientific article

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

scientific article

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

scientific article published on 6 November 2015

Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

scientific article published on 15 August 2020

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

scientific article published on 12 March 2015

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

scientific article

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

scientific article published on 17 March 2020

The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

scientific article published in December 2016

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

scientific article

The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution

scientific article published on 27 April 2015

The kinetics of helix unfolding of an azobenzene cross-linked peptide probed by nanosecond time-resolved optical rotatory dispersion.

scientific article

The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity

scientific article published on 17 July 2010

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

scientific article

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation

scientific article published on 3 November 2009

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

scientific article published on 18 September 2019

Using an azobenzene cross-linker to either increase or decrease peptide helix content upon trans-to-cis photoisomerization.

scientific article

List of works by Janet R Kumita

A FRET sensor for non-invasive imaging of amyloid formation in vivo

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

A Water-Soluble Azobenzene Cross-Linker for Photocontrol of Peptide Conformation

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis

ANS binding reveals common features of cytotoxic amyloid species

Achieving photo-control of protein conformation and activity: producing a photo-controlled leucine zipper.

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies

Alpha-helix formation in a photoswitchable peptide tracked from picoseconds to microseconds by time-resolved IR spectroscopy.

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

Analysis of the native structure, stability and aggregation of biotinylated human lysozyme

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

Clusterin protects neurons against intracellular proteotoxicity

Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution

Methods and models in neurodegenerative and systemic protein aggregation diseases

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes.

Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants.

Origins of helix-coil switching in a light-sensitive peptide.

Photo-control of peptide helix content by an azobenzene cross-linker: steric interactions with underlying residues are not critical

Population of nonnative states of lysozyme variants drives amyloid fibril formation

Prevention of peptide fibril formation in an aqueous environment by mutation of a single residue to Aib.

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

Protein amyloids develop an intrinsic fluorescence signature during aggregation

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

Reversible photocontrol of DNA binding by a designed GCN4-bZIP protein

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution

The kinetics of helix unfolding of an azobenzene cross-linked peptide probed by nanosecond time-resolved optical rotatory dispersion.

The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

Using an azobenzene cross-linker to either increase or decrease peptide helix content upon trans-to-cis photoisomerization.