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List of works by Hideo Yagita

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

scientific article published in Nature Communications

A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis

scholarly article

A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.

scientific article

A novel dendritic cell subset involved in tumor immunosurveillance

scientific article published on 29 January 2006

A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo

scientific article

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

scientific article published in June 2013

ATM-mediated DNA damage signals mediate immune escape through integrin-αvβ3-dependent mechanisms

scientific article

Activation of NK cell cytotoxicity

scientific article

Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi

scientific article

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

scientific article published on 25 April 2019

Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction.

scientific article published on 28 November 2011

Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor.

scientific article

Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity

scientific article

Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis

scientific article published on 01 February 2003

Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis

scientific article published on 01 July 2006

Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease ⬇️

scientific article published on August 3, 2010

Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells

scientific article published on 01 August 2005

Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation

scientific article published on 01 October 2002

Analysis of Ag-presenting cells in the conjunctiva during the development of experimental immune-mediated blepharoconjunctivitis

scientific article published on 01 October 2004

Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy

scientific article (publication date: 26 April 2011)

Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors

article

Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.

scientific article published on 18 February 2010

Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response

scholarly article

Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis

scientific article published on 11 December 2006

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

scientific article published on 11 February 2019

Antigen presented by tumors in vivo determines the nature of CD8+ T-cell cytotoxicity

scientific article published on 04 August 2009

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

article

Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft

scientific article

Autophagy-dependent regulation of tumor metastasis by myeloid cells

scientific article published on 7 July 2017

B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism

article

B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts

scientific article published on 01 November 2006

B7-H3 regulates the development of experimental allergic conjunctivitis in mice

scientific article published on 23 August 2007

B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice

scientific article published on 01 September 2002

Beta2-microglobulin required for cell surface expression of blastocyst MHC.

scientific article

Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo

scientific journal article

Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.

scientific article

Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation ⬇️

scientific article published on October 15, 2003

Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production

scientific article published on August 2005

Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cells

scientific article published on 01 December 2002

Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation

scientific article

Blockade of the OX40 ligand prolongs corneal allograft survival

scientific article published on 01 December 2007

Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity

scientific article

CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors

scientific article

CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity

scientific article published on 16 November 2018

CD27 Agonism Plus PD-1 Blockade Recapitulates CD4+ T-cell Help in Therapeutic Anticancer Vaccination.

scientific article published on 28 March 2016

CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intratracheal delivery of alloantigen ⬇️

scientific article published on September 15, 2003

CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease

scientific article published on 01 September 2004

CD4+ T cells kill Id+ B-lymphoma cells: FasLigand-Fas interaction is dominant in vitro but is redundant in vivo.

scientific article published on December 2004

CD49b-dependent establishment of T helper cell memory.

scientific article published on 30 July 2013

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

scientific article published on 16 March 2012

Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer.

scientific article

Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer

scientific article (publication date: 15 April 2005)

Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice.

scientific article published on 20 June 2017

Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy

scientific article

Combination Anti-CTLA-4 and Anti-RANKL in Metastatic Melanoma

scientific article published on 13 October 2014

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

scholarly article

Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules

Combined natural killer T-cell based immunotherapy eradicates established tumors in mice

scientific article published on August 2007

Concurrent induction of T-cell activation and apoptosis of osteosarcoma cells by adenovirus-mediated B7-1/Fas chimeric gene transfer

scientific article published on September 2003

Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor

scientific article

Correction: Figure 7

Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis

scientific article published on 11 January 2010

Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection

scientific article

Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease

scientific article published on 14 October 2007

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

scientific article

Critical role of OX40 in CD28 and CD154-independent rejection.

scientific article

Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy

scientific article published on 22 January 2008

Critical, but conditional, role of OX40 in memory T cell-mediated rejection

scientific article published in February 2006

Cross-talks of tumor and myeloid cells regulate the therapeutic responses to chemotherapy by modulating innate immune responses.

scientific article published on 7 November 2013

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

scientific article

Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy

scientific article published on 01 November 2008

Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination

scientific article published on December 2003

Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells

scientific article published on 16 August 2006

DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases

scientific article

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

scholarly article

Death receptor ligation or exposure to perforin trigger rapid egress of the intracellular parasite Toxoplasma gondii

scientific article published on December 2007

Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice

scientific article published in April 2008

Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia

scientific article

Differential contributions of B7-1 and B7-2 to the development of murine experimental allergic conjunctivitis

article

Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma

scientific article published on 26 February 2015

Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases.

scientific article

Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands

scientific article published on 30 January 2009

Effects of anti-CD70 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

scientific article

Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis.

scientific article

Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice

scientific article published on 01 October 2005

Eradication of established tumors in mice by a combination antibody-based therapy

scientific article published on 7 May 2006

Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

scientific article published on 01 March 2002

Expression of costimulatory molecules (4-1BBL and Fas) and major histocompatibility class I chain-related A (MICA) in aortic tissue with Takayasu's arteritis

scientific article published on 27 January 2004

Expression of programmed death 1 ligands by murine T cells and APC

scientific article (publication date: 15 November 2002)

Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy

scientific article published on 01 May 2002

FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer

scientific article

Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism.

scientific article

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

scientific article published on February 2013

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

scientific article published on 23 November 2015

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.

scientific article published in July 2013

ICOS costimulates invariant NKT cell activation

scientific article published on 01 February 2005

IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide

scientific article published on 01 September 2002

IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.

scientific article published on 3 March 2005

IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy

scientific article published on May 2006

Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection

scientific article

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

scientific article published in February 2002

Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen

scholarly article

Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy

scientific article

Induction of tumor-specific T cell memory by NK cell–mediated tumor rejection

scientific article published on 17 December 2001

Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion

scientific article published on 22 October 2014

Inhibition of murine corneal allograft rejection by treatment with antibodies to CD80 and CD86

scientific article published on 01 January 2002

Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells

scientific article published on 6 December 2014

Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence

scientific article published on 14 November 2012

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

scientific article

Integrin β1 Promotes the Interaction of Murine IgG3 with Effector Cells

scientific article published on 20 March 2019

Interleukin 21 enhances antibody-mediated tumor rejection

scientific article

Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells

scientific article published on 25 July 2015

Interleukin-10 but not transforming growth factor-beta is essential for generation and suppressor function of regulatory cells induced by intratracheal delivery of alloantigen

scientific article published on 01 March 2005

Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections ⬇️

scientific article published on October 31, 2003

Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis

scientific article published on 01 November 2006

Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis

scientific article (publication date: 15 September 2003)

JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis

scientific article published on 01 November 2007

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

scientific article published on 09 January 2003

Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity

scientific article published on 01 August 2002

Molecular cloning, functional characterization, and enzyme-linked immunosorbent assay of cynomolgus monkey Fas ligand.

scientific article

Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses

scientific article published on 12 September 2013

NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy

scientific article

NK cells contribute to the skin graft rejection promoted by CD4+ T cells activated through the indirect allorecognition pathway.

scientific article

NKG2A inhibits invariant NKT cell activation in hepatic injury

scientific article

NKT cells - conductors of tumor immunity?

scientific article

Natural killer cell lytic activity and CD56(dim) and CD56(bright) cell distributions during and after intensive training

scientific article published on 29 January 2004

Nature's TRAIL--on a path to cancer immunotherapy

scientific article

New aspects of natural-killer-cell surveillance and therapy of cancer

scientific article

Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis

scientific article published on 21 November 2008

Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine

scientific article published on 22 October 2010

OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation

scientific article

Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors.

scientific article

Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.

scientific article published in October 2004

PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism

scientific article

PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells

scientific article

Peptide Vaccine Induces Enhanced Tumor Growth Associated with Apoptosis Induction in CD8+ T Cells ⬇️

scientific article published on August 23, 2010

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

scientific article

Pharmacologic inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia

scientific article published on 16 July 2016

Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy

scientific article

Preferential contribution of B7‐H1 to programmed death‐1‐mediated regulation of hapten‐specific allergic inflammatory responses ⬇️

scientific article published on October 1, 2003

Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease

scientific article published on 01 October 2006

Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen

scientific article

Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies

scientific article published on 8 May 2012

Rapid lethality of hosts by interleukin-12 following H-2 compatible allogeneic bone marrow transplantation: Reminiscence of gut-associated acute graft-versus-host reaction

scientific article published on 01 October 2002

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

scientific article

Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/αCD40 therapy

scientific article

Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates

scientific article published on 9 June 2005

Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3

scientific article published on 01 April 2002

Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade

scientific article

Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen

Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection

scientific article published in May 2005

Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice

scientific article published on 14 December 2007

Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3.

scientific article

Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis

scientific article published on 01 March 2002

Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors.

scientific article published in October 2004

Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer

scientific article

Sequential production of interferon-gamma by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of alpha -galactosylceramide

scientific article published on 01 February 2002

Structure and function of lipid rafts in human activated T cells

scientific article published on 20 June 2005

Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL)

scientific article published on 01 October 2002

Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice

scientific article published in April 2009

Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.

scientific article

T cells require TRAIL for optimal graft-versus-tumor activity

scientific article

T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase

scientific article published on 15 May 2007

TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches

scientific article published in February 2007

TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells

scientific article published on 27 December 2002

TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice

scientific article published on 01 October 2005

TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer

scientific article

TRAIL and its receptors as targets for cancer therapy

scientific article published in October 2004

TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver

scientific article published on 09 November 2004

TRAIL signaling is proinflammatory and proviral in a murine model of rhinovirus 1B infection.

scientific article published on 11 November 2016

TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage

scientific article

TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF.

scientific article published on May 2004

The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease

scientific article published on 31 January 2014

The curative outcome of radioimmunotherapy in a mouse breast cancer model relies on mTOR signaling

scientific article

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

scientific article

The interaction between ICOS and B7RP-1 is not required for the development of experimental murine allergic conjunctivitis

scientific article published on 07 November 2005

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

scientific article

The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo

scientific article published in March 2003

The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis

scientific article published on 01 November 2006

Therapeutic effect of anti-αv integrin mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

scientific article published on 3 January 2014

Therapeutic effects of anti-Delta1 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

scientific article published on 31 August 2012

Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer

scientific article

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

scientific article

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration

scientific article

Transmission of Toxoplasma gondii from infected dendritic cells to natural killer cells

scientific article published on 12 January 2009

Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody

scientific article published on 29 April 2008

Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus

scientific article published on 04 June 2009

Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer

scientific article published on January 2003

Two different transcription factors discriminate the -315C>T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to -315C and of a high mobility group-related molecule to -315T.

scientific article

Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex

scientific journal article

Visceral Adipose Tissue-derived Serine Proteinase Inhibitor Inhibits Apoptosis of Endothelial Cells as a Ligand for the Cell-Surface GRP78/Voltage-dependent Anion Channel Complex

scientific article published on 10 January 2013

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