Search filters

List of works by Tzu-Ping Ko

"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

scientific article published on 7 December 2017

: a comparative study with human GNE.

scientific article

A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products

scientific article

Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase

scientific article

An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells

Antibacterial drug leads: DNA and enzyme multitargeting

scientific article published on 22 January 2015

Binding Modes of Zaragozic Acid A to Human Squalene Synthase and Staphylococcal Dehydrosqualene Synthase

scientific article

Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates

scientific article published on 31 August 2010

Binding mode of the oxidized α-anomer of NAD+ to RSP, a Rex-family repressor

scientific article

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

scientific article

Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton

scientific article (publication date: August 2003)

Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-β-endoglucanase from Thielavia terrestris.

scientific article

Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance

scientific article

Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism

scientific article

Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans

scientific article published on 03 January 2020

Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase.

scientific article published on 16 March 2017

Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination ⬇️

scientific article published on November 15, 2003

Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase fromSaccharomyces cerevisiaeand the Mechanism of Product Chain Length Determination

scientific article published in Journal of Biological Chemistry

Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation

scientific article

Crystal structure and functional analysis of the glutaminyl cyclase from Xanthomonas campestris

scientific article

Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase

scientific article published on 01 May 2021

Crystal structure and substrate specificity of plant adenylate isopentenyltransferase from Humulus lupulus: distinctive binding affinity for purine and pyrimidine nucleotides

scientific article

Crystal structure and substrate-binding mode of a novel pectate lyase from alkaliphilic Bacillus sp. N16-5

scientific article

Crystal structure and substrate-binding mode of cellulase 12A from Thermotoga maritima

scientific article

Crystal structure of D-aminoacylase from Alcaligenes faecalis DA1. A novel subset of amidohydrolases and insights into the enzyme mechanism

scientific article

Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis

scientific article

Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis

scientific article published on 01 February 2019

Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus) ⬇️

scientific article published on March 1, 2004

Crystal structure of infectious bursal disease virus VP2 subviral particle at 2.6A resolution: implications in virion assembly and immunogenicity

scientific article published on 31 March 2006

Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni

scientific article published on 02 March 2019

Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins

scientific article

Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein

scientific article

Crystal structure of vespid phospholipase A(1) reveals insights into the mechanism for cause of membrane dysfunction

scientific article published on 18 November 2015

Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution

scientific article (publication date: 23 May 2003)

Crystal structures of Bacillus alkaline phytase in complex with divalent metal ions and inositol hexasulfate

scientific article

Crystal structures of Staphylococcal SaeR reveal possible DNA-binding modes

scientific article published on 2 May 2016

Crystal structures of d-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars

scientific article

Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation

scientific article

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase fromEscherichia colireveal the catalytic and chain-length determining mechanisms ⬇️

scientific article

Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons

scientific article

Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins

scientific article

Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis

scientific article published on 23 March 2005

Crystallization and preliminary X-ray diffraction analysis of (R)-carbonyl reductase from Candida parapsilosis

scientific article

Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168.

scientific article published on 25 December 2012

Crystallization and preliminary X-ray diffraction analysis of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485

scientific article

Crystallization and preliminary X-ray diffraction analysis of a novel β-L-arabinofuranosidase (HypBA1) from Bifidobacterium longum.

scientific article

Crystallization and preliminary X-ray diffraction analysis of the S-adenosylhomocysteine hydrolase (SAHH) from Thermotoga maritima

scientific article

Current Progresses in Phytase Research: Three-Dimensional Structure and Protein Engineering

Design and characterization of a multimeric DNA binding protein using Sac7d and GCN4 as templates

scientific article published in September 2005

Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues

scientific article

Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling

scientific article published on 15 November 2019

Distinct structural features of Rex-family repressors to sense redox levels in anaerobes and aerobes

scientific article published on 13 November 2014

Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose

scientific article

Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase

scientific article

Enhanced activity of Thermotoga maritima cellulase 12A by mutating a unique surface loop

scientific article

Enhanced specificity of mint geranyl pyrophosphate synthase by modifying the R-loop interactions

scientific article

Enzymatic characterization and crystal structure analysis of Chlamydomonas reinhardtii dehydroascorbate reductase and their implications for oxidative stress

scientific article published on 3 October 2017

Functional and structural analyses of a 1,4-β-endoglucanase from Ganoderma lucidum

scientific article

Functional and structural studies of pullulanase from Anoxybacillus sp. LM18-11.

scientific article published on 22 April 2014

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

scientific article published on 24 March 2017

Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures

scientific article

Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions

scientific article published on 17 May 2019

Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein

scientific article published in November 2004

Improving specific activity and thermostability of Escherichia coli phytase by structure-based rational design.

scientific article

Improving the catalytic performance of a GH11 xylanase by rational protein engineering

scientific article published on 19 June 2015

Improving the specific activity of β-mannanase from Aspergillus niger BK01 by structure-based rational design

scientific article published on 28 January 2014

Inactive S298R disassembles the dodecameric L-aspartate 4-decarboxylase into dimers

scientific article published on 3 July 2008

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †

scientific article

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB fromBacillus subtilisandStaphylococcus aureus

scientific article

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes

scientific article

Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis

scientific article published on 16 March 2016

Mechanism of action and inhibition of dehydrosqualene synthase

scientific article

Mechanism of the maturation process of SARS-CoV 3CL protease

scientific article published on 23 March 2005

Modulation of Substrate Specificities of d-Sialic Acid Aldolase through Single Mutations of Val-251 ⬇️

scientific article published on January 26, 2011

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.

scientific article

NADH/NADPH bi-cofactor-utilizing and thermoactive ketol-acid reductoisomerase from Sulfolobus acidocaldarius.

scientific article

Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein ⬇️

scientific article published on March 26, 2013

Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor

scientific article

Preliminary X-ray diffraction analysis of a thermophilic β-1,3-1,4-glucanase from Clostridium thermocellum

scientific article

Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli

scientific article

Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase from Escherichia coli.

scientific article published on 27 February 2013

Preliminary X-ray diffraction analysis of thermostable β-1,4-xylanase from Streptomyces sp. S9.

scientific article published on 24 December 2013

Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d

scientific article

Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION

scientific article

Purification, crystallization and preliminary X-ray analysis of immunogenic virus-like particles formed by infectious bursal disease virus (IBDV) structural protein VP2.

scientific article published on 27 June 2003

Rational design to improve thermostability and specific activity of the truncated Fibrobacter succinogenes 1,3-1,4-β-d-glucanase ⬇️

scientific article published on September 30, 2011

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Roles of tryptophan residue and disulfide bond in the variable lid region of oxidized polyvinyl alcohol hydrolase

scientific article

SH3-like motif-containing C-terminal domain of staphylococcal teichoic acid transporter suggests possible function

scientific article

Squalene synthase as a target for Chagas disease therapeutics

scientific article

Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor

scientific article

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

scientific article

Structural Insights to the Heterotetrameric Interaction between the Vibrio parahaemolyticus PirAvp and PirBvp Toxins and Activation of the Cry-Like Pore-Forming Domain.

scientific article published on 22 April 2019

Structural analyses and yeast production of the β-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum

scientific article

Structural analysis of a glycoside hydrolase family 11 xylanase from Neocallimastix patriciarum: insights into the molecular basis of a thermophilic enzyme.

scientific article

Structural analysis of the antibiotic-recognition mechanism of MarR proteins ⬇️

scientific article published on May 16, 2013

Structural and Functional Analyses of Five Conserved Positively Charged Residues in the L1 and N-Terminal DNA Binding Motifs of Archaeal RadA Protein

scientific article

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

scientific article published on 10 November 2017

Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485

scientific article

Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production

scientific article

Structural and mutagenetic analyses of a 1,3-1,4-β-glucanase from Paecilomyces thermophila

scientific article

Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2

scientific article

Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein

scientific article published on 17 February 2017

Structural basis for the antibody neutralization ofHerpes simplex virus

scientific article

Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range

scientific article

Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU-HL1

scientific article published on 01 July 2020

Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis

scientific article published on 8 December 2017

Structural insight into catalytic mechanism of PET hydrolase

scientific article published on 13 December 2017

Structural insight into potential cold adaptation mechanism through a psychrophilic glycoside hydrolase family 10 endo-β-1,4-xylanase

scientific article

Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase

scientific article published on 29 May 2020

Structural insights into enzymatic degradation of oxidized polyvinyl alcohol

scientific article

Structural insights into the catalytic mechanism of human squalene synthase

scientific article

Structural insights of the ssDNA binding site in the multifunctional endonuclease AtBFN2 from Arabidopsis thaliana.

scientific article

Structural perspectives of an engineered β-1,4-xylanase with enhanced thermostability

scientific article

Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis

scientific article

Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase.

scientific article published on 29 February 2016

Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis

scientific article

Structure and Mechanism of an Arabidopsis Medium/Long-Chain-Length Prenyl Pyrophosphate Synthase

scientific article

Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.

scientific article

Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase

scientific article published on 11 May 2015

Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase

scientific article

Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation

scientific article

Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec.

scientific article

Structure of the alkalohyperthermophilic Archaeoglobus fulgidus lipase contains a unique C-terminal domain essential for long-chain substrate binding

scientific article

Structure of undecaprenyl pyrophosphate synthase from Acinetobacter baumannii

scientific article published on 16 November 2018

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.

scientific article published on 26 July 2016

Structure, assembly, and mechanism of a PLP-dependent dodecameric L-aspartate beta-decarboxylase

scientific article

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

scientific article

Structure, mechanism and function of prenyltransferases

scientific article

Structure-Based Inhibitors Exhibit Differential Activities againstHelicobacter pyloriandEscherichia coliUndecaprenyl Pyrophosphate Synthases

scientific article

Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+) , NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms.

scientific article

Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets

scientific article published on 23 February 2016

Structures of human MST3 kinase in complex with adenine, ADP and Mn2+

scientific article

Structures of the hyperthermophilic chromosomal protein Sac7d in complex with DNA decamers

scientific article published on 21 July 2004

Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies

scientific article published on April 2004

Substrate binding of a GH5 endoglucanase from the ruminal fungusPiromyces rhizinflata

scientific article

Substrate binding to a GH131 β-glucanase catalytic domain from Podospora anserina

scientific article published on 20 July 2013

Substrate-analogue complex structure of Mycobacterium tuberculosis decaprenyl diphosphate synthase

scientific article published on 13 March 2019

Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase

scientific article published on 20 April 2022

Terpyridine Platinum(II) Complexes Inhibit Cysteine Proteases by Binding to Active-site Cysteine ⬇️

scientific article published on October 1, 2011

Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1

scientific article

The 1.35 A structure of cadmium-substituted TM-3, a snake-venom metalloproteinase from Taiwan habu: elucidation of a TNFalpha-converting enzyme-like active-site structure with a distorted octahedral geometry of cadmium

scientific article

The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA

scientific article

The Hexameric Structures of Human Heat Shock Protein 90 ⬇️

scientific article (publication date: 2011)

The Refined Crystal Structure of an Eel Pout Type III Antifreeze Protein RD1 at 0.62-Å Resolution Reveals Structural Microheterogeneity of Protein and Solvation

scientific article

The T4 phage DNA mimic protein Arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS.

scientific article

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

scientific article published on 8 December 2017

The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

scientific article

The structural interpretations of residue Ser297 in catalytic efficiency of Escherichia coli phenylalanine aminotransferase

scientific article published in April 2003

The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485

scientific article

Three New Structures of Left-Handed RadA Helical Filaments: Structural Flexibility of N-Terminal Domain Is Critical for Recombinase Activity

scientific article

Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase

scientific article

Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase

scientific article published on 02 April 2019

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

scientific article published on 14 March 2016

White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly

scientific article

Paulina is supported by:

About Paulina

Help