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List of works by Marcia C. Haigis

A metabolic prosurvival role for PML in breast cancer.

scientific article

A metabolomic signature of the APOE2 allele

scientific article published in February 2023

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

scientific article published on 3 January 2013

Accumulation of succinate controls activation of adipose tissue thermogenesis

scientific article published in Nature

Acetylation-dependent regulation of Skp2 function

scientific article

Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming

scientific article published on 08 May 2019

Altered metabolic requirements in cancer cell migration and metastasis.

scientific article published in June 2012

Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system

scientific article

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

scientific article

An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues

scientific article published on 4 September 2017

Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway

scientific article published on 02 December 2020

Bioinformatic and molecular investigation of Sirt3 expression.

scientific article published in June 2012

Calorie restriction extends yeast life span by lowering the level of NADH.

scientific article

Cellular metabolic response to DNA damage.

scientific article published in June 2012

Chemical and Physiological Features of Mitochondrial Acylation

scientific article published on 01 November 2018

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

scientific article published on 25 May 2021

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

scientific article published on 2 July 2015

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

article published in the Proceedings of the National Academy of Sciences of the United States of America

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

scientific article published on 30 March 2008

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

scientific article published on 01 March 2018

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

scientific article published on 12 June 2013

Evolution of Ribonuclease Inhibitor by Exon Duplication

scientific article published in 2002

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

scientific article published on September 2011

Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein

scientific article

From Sirtuin Biology to Human Diseases: An Update ⬇️

scientific article published on October 18, 2012

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

scientific article published on 27 March 2013

HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS

scientific article published on 30 May 2013

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

scientific article published on 14 March 2019

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

scientific article published on 30 July 2020

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3

scientific article published on 18 June 2018

Intersections between mitochondrial sirtuin signaling and tumor cell metabolism.

scientific article published on 21 April 2015

KFERQ sequence in ribonuclease A-mediated cytotoxicity

scientific article published on 18 January 2002

Leveraging insights into cancer metabolism-a symposium report

scientific article published on 02 December 2019

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

scientific article published in 2021

Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma

scientific article published on 25 November 2019

Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter.

scientific article published in January 2014

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

scientific journal article

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

scientific article (publication date: November 2006)

Mammalian sirtuins: biological insights and disease relevance

scientific article (publication date: 2010)

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

scientific article published on 12 October 2017

Metabolic regulation by SIRT3: implications for tumorigenesis

scientific article published on 27 June 2012

Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism

scientific article published in 2021

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

scientific article

Mitochondria and Cancer.

scientific article published in July 2016

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

scientific article published on July 2016

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.

scientific article published on 27 October 2016

Mitochondrial Sirtuins and Molecular Mechanisms of Aging.

scientific article published on 9 March 2017

Mitochondrial metabolism in T cell activation and senescence: a mini-review

scientific article

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.

scientific article

Nitrogen Metabolism in Cancer and Immunity

scientific article published on 10 March 2020

Nuclear respiratory factor 2 induces SIRT3 expression.

scientific article published on 24 June 2015

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

scientific article published on 07 December 2020

Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function

scientific article published on 30 September 2022

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

scientific article

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

scientific article published on 09 July 2020

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

scientific article published on September 2016

Pancreatic cancers require autophagy for tumor growth

scientific article (publication date: April 2011)

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

scientific article published on 04 December 2020

REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors

scientific article published on 09 April 2020

ROLE OF MITOCHONDRIA IN AGING

Regulation of RAS oncogenicity by acetylation

scientific article

Regulation of metabolism by sirtuins.

scientific article published in June 2012

Ribonuclease inhibitor as an intracellular sentry

scientific article

Ribonuclease inhibitor: structure and function

scientific article

Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimers and Parkinsons Diseases ⬇️

scientific article published on January 1, 2011

SIRT1 shows no substrate specificity in vitro

scientific article published on 6 January 2005

SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis

scientific article

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

scientific article

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.

scientific article published on 09 June 2014

SIRT3 regulation of mitochondrial oxidative stress ⬇️

scientific article published on August 31, 2012

SIRT4 Is a Regulator of Insulin Secretion

scientific article published in June 2017

SIRT4 controls the balance between lipid synthesis and catabolism by repressing malonyl-CoA decarboxylase.

scientific article published in June 2012

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

scientific journal article

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

scientific journal article

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

scientific article

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma

scientific article published on 24 December 2013

SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation

scientific article

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

scientific journal article

Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway

scientific article published on January 2003

Short-term calorie restriction enhances skeletal muscle stem cell function

scientific article

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

scientific article published on 20 September 2010

Sirtuins and the Metabolic Hurdles in Cancer

scientific article published on June 2015

Sirtuins in Aging and Age-Related Diseases

Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism

scientific article

Sirtuins regulate key aspects of lipid metabolism

scientific article published on 02 December 2009

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

scientific article published on 3 February 2012

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.

scientific article published in February 2018

Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity

scholarly article published on 22 January 2024

Strength in numbers: Phosphofructokinase polymerization prevails in the liver.

scientific article

Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity

scientific article

Superoxide dismutase 1 knock-down induces senescence in human fibroblasts

scientific article

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

scientific article published on 3 October 2016

Sweet Temptation: From Sugar Metabolism to Gene Regulation

scientific article published on 01 December 2019

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

scientific article published on 6 March 2012

T Cell Activation Depends on Extracellular Alanine

scientific article published on 01 September 2019

The Aging Stress Response ⬇️

scientific article published on October 22, 2010

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

scientific article

The effects of age and systemic metabolism on anti-tumor T cell responses

scientific article published on 10 November 2020

The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function

scientific article published on 05 May 2020

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

scientific journal article

The multifaceted contributions of mitochondria to cellular metabolism.

scientific article published on 27 June 2018

The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation

scientific article published on 5 November 2013

The role of SIRT3 in regulating cancer cell metabolism.

scientific article published in June 2012

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

scientific article published on 13 September 2018

Translocation of a beta-peptide across cell membranes

scientific article published in January 2002

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

scientific article published in 2022

l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism

scholarly article by Yusuke Adachi published in November 2018

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

scientific article published on 29 September 2017

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