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List of works by Gary B Huffnagle

"B" for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease

scientific article

A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community

scientific article

A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs

scientific article published on 30 June 2016

Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes

scientific article

Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response

scientific article published in September 2013

Analysis of culture-dependent versus culture-independent techniques for identification of bacteria in clinically obtained bronchoalveolar lavage fluid

scientific article

Analysis of the lung microbiome in the "healthy" smoker and in COPD

scientific article published in 2011

Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals

scientific article

Another piece in the 'research mosaic' that describes the role of the lung microbiome in COPD

scientific article published on 19 July 2016

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

scientific article (publication date: 20 January 2014)

Application of a neutral community model to assess structuring of the human lung microbiome

scientific article

Bacillus anthracis phospholipases C facilitate macrophage-associated growth and contribute to virulence in a murine model of inhalation anthrax

scientific article

Bacterial Dissemination to the Brain in Sepsis

scientific article published on 12 December 2017

Bacterial Topography of the Healthy Human Lower Respiratory Tract

scientific article (publication date: 14 February 2017)

Butyrate increases IL-23 production by stimulated dendritic cells

scientific article

CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans.

scientific article published on July 2008

CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

article

CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death

scientific article

CD8+ T cell contributions to allergen induced pulmonary inflammation and airway hyperreactivity.

scientific article published in July 2005

CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence

scientific article published on March 2004

Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy

scientific article

Cell-associated bacteria in the human lung microbiome

scientific article published on 18 August 2014

Changes in the lung microbiome following lung transplantation include the emergence of two distinct Pseudomonas species with distinct clinical associations

scientific article

Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection

scientific article

Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidia.

scientific article

Comparative genomics of Pseudomonas fluorescens subclade III strains from human lungs

scientific article

Control of mucosal polymicrobial populations by innate immunity

scientific article published on 25 June 2009

Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis

scientific article published on 09 June 2020

Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung

scientific article published on 13 February 2009

Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase

scientific article published on 8 December 2006

Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13

scientific article

Differential roles of CC chemokine ligand 2/monocyte chemotactic protein-1 and CCR2 in the development of T1 immunity

scientific article published on 01 May 2002

Distinct compartmentalization of CD4+ T-cell effector function versus proliferative capacity during pulmonary cryptococcosis

scientific article

Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis

scientific article published on 01 January 2005

Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection.

scientific article

Does the microbiota regulate immune responses outside the gut?

scientific article

Draft Genome Sequences of Five Pseudomonas fluorescens Subclade I and II Strains, Isolated from Human Respiratory Samples

scientific article published on 30 July 2015

Draft Genome Sequences of Seven Pseudomonas fluorescens Subclade III Strains Isolated from Cystic Fibrosis Patients

scientific article

Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung

scientific article

Dysbiosis in the intensive care unit: Microbiome science coming to the bedside

scientific article published on 11 October 2016

Ecological succession of bacterial communities during conventionalization of germ-free mice

scientific article

Effect of a CD4-depleting antibody on the development of Cryptococcus neoformans-induced allergic bronchopulmonary mycosis in mice

scientific article

Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans

scientific article

Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungs

scientific article published on 16 August 2007

Effects of tumor necrosis factor alpha on dendritic cell accumulation in lymph nodes draining the immunization site and the impact on the anticryptococcal cell-mediated immune response

scientific article

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome

scientific article (publication date: 18 July 2016)

GI microbiota and regulation of the immune system. Preface

scientific article published on 01 January 2008

Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection

scientific article published in June 2005

Genome Sequences of 12 Pseudomonas lundensis Strains Isolated from the Lungs of Humans

scientific article published on 15 February 2018

Homeostasis and its disruption in the lung microbiome

scientific article published on 2 October 2015

Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease

scientific article published on 6 May 2015

Host and microbiota factors that control Klebsiella pneumoniae mucosal colonization in mice

scientific article published on 13 August 2008

Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

scientific article

Immune Reconstitution Disease In Crytococcus Neoformans-Infected Mice Associated With An Imbalance Between Inflammatory And Regulatory Cytokines

scientific article published in May 2011

Immune regulation during allergic bronchopulmonary mycosis: lessons taught by two fungi

scientific article

Immunologic homeostasis during infection: coexistence of strong pulmonary cell-mediated immunity to secondary Cryptococcus neoformans infection while the primary infection still persists at low levels in the lungs.

scientific article published in October 2006

Increase in dietary fiber dampens allergic responses in the lung

scientific article published in February 2014

Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection

scientific article

Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model

scientific article published on 7 April 2008

Innate and adaptive determinants of host susceptibility to medically important fungi

scientific article

Innate immunity for biodefense: a strategy whose time has come

scientific article

Inter-Kingdom Communication and Regulation of Mucosal Immunity by the Microbiome

scientific article published on 17 December 2020

Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia.

scientific article published on 17 January 2012

Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production

scientific article published on 09 December 2013

Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice

scientific article published on April 2015

Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice

scientific article

Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis

scientific article published on 10 October 2011

Intraalveolar Catecholamines and the Human Lung Microbiome.

scientific article published on July 2015

Investigating invasive aspergillosis

scientific article published on 01 November 2002

Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia.

scientific article

Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae.

scientific article

Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia

scientific article

Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis

scientific article

Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation

scientific article published on 01 November 2018

Lung Microbiome Is Influenced by the Environment and Asthmatic Status in an Equine Model of Asthma

scientific article published on 01 February 2019

Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis

scientific article published on 01 May 2019

Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients

scientific article published on 01 March 2020

Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice

scientific article published on 01 August 2020

Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study

scientific article

Macrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection

scientific article published on 18 June 2013

Mathematical modeling of primary succession of murine intestinal microbiota.

scientific article

Mechanisms of cryptococcal virulence and persistence

scientific article published on August 2010

Microbes Are Associated with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis

scientific article published in July 2017

Microbes mediated host innate immune response in idiopathic pulmonary fibrosis

article

Microbiology, genomics, and clinical significance of the Pseudomonas fluorescens species complex, an unappreciated colonizer of humans

scientific article

Modulation of post-antibiotic bacterial community reassembly and host response by Candida albicans

scientific article

Modulation of the pulmonary type 2 T-cell response to Cryptococcus neoformans by intratracheal delivery of a tumor necrosis factor alpha-expressing adenoviral vector

scientific article

Novel chemokine responsiveness and mobilization of neutrophils during sepsis

scientific article

Overview of gut immunology

scientific article published on January 2008

Potential contribution of fungal infection and colonization to the development of allergy

scientific article

Preparation of metagenomic DNA from bronchoalveolar lavage fluids of patients with chronic obstructive pulmonary diseases

scientific article

Procalcitonin levels associate with severity of Clostridium difficile infection

scientific article

Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes

scientific article

Production of prostaglandins and leukotrienes by pathogenic fungi

scientific article published on January 2002

Promotion of lung health: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

scientific article

Pulmonary defenses against fungi.

scientific article published in February 2004

Radiographic Honeycombing and Altered Lung Microbiota in Patients with Idiopathic Pulmonary Fibrosis

scientific article published on 01 December 2019

Rapid Pathogen Identification in Bacterial Pneumonia Using Real-Time Metagenomics

scientific article published on 5 May 2017

Regulation of Candida albicans morphogenesis by fatty acid metabolites

scientific article

Repeated exposure to Aspergillus fumigatus conidia results in CD4+ T cell-dependent and -independent pulmonary arterial remodeling in a mixed Th1/Th2/Th17 microenvironment that requires interleukin-4 (IL-4) and IL-10.

scientific article published on 7 November 2011

Reply to Clinical Metagenomics for the Diagnostic of Hospital-acquired Infections: Promises and Hurdles

scientific article published on 5 July 2017

Respiratory Tract Colonization by Candida species Portends Worse Outcomes in Immunocompromised Patients

scientific article published on 01 November 2018

Responders and non-responders to probiotic interventions: how can we improve the odds?

scientific article

Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99

scientific article

Role and development of TH1/TH2 immune responses in the lungs

scientific article

Role of GM-CSF in the inflammatory cytokine network that regulates neutrophil influx into the colonic mucosa during Clostridium difficile infection in mice

scientific article published on 21 July 2014

Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis

scientific article published in May 2005

Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production

scientific article

Role of antibiotics and fungal microbiota in driving pulmonary allergic responses

scientific article published on September 2004

Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans

scientific article published on 29 June 2009

Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis

scientific article published on March 2007

Role of interferon-γ and inflammatory monocytes in driving colonic inflammation during acute Clostridium difficile infection in mice

scientific article published on 20 December 2016

Role of neutrophils in preventing and resolving acute fungal sinusitis

scientific article

Role of oxylipins and other lipid mediators in fungal pathogenesis

scientific article published on August 2006

Significance of the microbiome in chronic obstructive pulmonary disease

scientific article

Significance of the microbiome in obstructive lung disease

scientific article published on 8 February 2012

Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography

scientific article published on June 2015

Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice

scientific article published on 05 March 2013

Symptom-related sputum microbiota in stable chronic obstructive pulmonary disease

article

TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs

scientific article

Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection.

scientific article published on 14 September 2009

The "Microflora Hypothesis" of allergic disease

scientific article published on January 2008

The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease

scientific article published on 9 July 2015

The Lung Microbiota of Healthy Mice Are Highly Variable, Cluster by Environment, and Reflect Variation in Baseline Lung Innate Immunity

scientific article published on 01 August 2018

The Microbiome and the Respiratory Tract

scientific article published on 2 November 2015

The bacterial microbiota in inflammatory lung diseases

scientific article published on 26 June 2015

The effects of intestinal microbial community structure on disease manifestation in IL-10-/- mice infected with Helicobacter hepaticus

scientific article published on 10 May 2013

The emerging world of the fungal microbiome

scientific article

The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans

scientific article

The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection

scientific article published on May 2011

The lung microbiome and viral-induced exacerbations of chronic obstructive pulmonary disease: new observations, novel approaches

scientific article published in November 2013

The microbiome and regulation of mucosal immunity

scientific article

The microbiome in respiratory medicine: current challenges and future perspectives

scientific article

The microbiome in wound repair and tissue fibrosis

scientific article

The microbiome of the lung

scientific article

The microbiota and allergies/asthma

scientific article

The microbiota in respiratory disease

scientific article published on 01 May 2012

The respiratory microbiome: an underappreciated player in the human response to inhaled pollutants?

scientific article

The role of Gr-1(+) cells and tumour necrosis factor-α signalling during Clostridium difficile colitis in mice

scientific article

The role of dendritic cells in the development of acute dextran sulfate sodium colitis

scientific article published on 01 November 2007

The role of laccase in prostaglandin production by Cryptococcus neoformans

scientific article published on 11 April 2008

The role of the bacterial microbiome in lung disease

scientific article

The role of the microbiome in exacerbations of chronic lung diseases

scientific article

The significance of Candida in the human respiratory tract: our evolving understanding

scientific article published in April 2017

The systemic inflammatory response to Clostridium difficile infection

scientific article

Total parenteral nutrition-associated lamina propria inflammation in mice is mediated by a MyD88-dependent mechanism

scientific article published on 10 May 2013

Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis

scientific article published on March 2014

Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells

scientific article

Transport of Bacillus anthracis from the lungs to the draining lymph nodes is a rapid process facilitated by CD11c+ cells

scientific article published on 25 February 2010

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology

scientific article

Understanding the role of the microbiome in chronic obstructive pulmonary disease: principles, challenges, and future directions

scientific article published on 23 June 2016

Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion

scientific article

Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise

scientific article

Use of direct gradient analysis to uncover biological hypotheses in 16s survey data and beyond

scientific article

Whole lung tissue is the preferred sampling method for amplicon-based characterization of murine lung microbiota ⬇️

scientific article published on 05 May 2021

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