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List of works by Peter Aplan

"You break it, you fix it.".

scientific article

A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement.

scientific article

A robust in vivo model for B cell precursor acute lymphoblastic leukemia

scientific article

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

scientific article

A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia

scientific article published on 05 December 2019

Accurate Medicine: Indirect Targeting of NPM1-Mutated AML.

scientific article published on October 2016

Age-related epigenetic drift in the pathogenesis of MDS and AML.

scientific article published on 10 January 2014

All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo

scientific article published on 21 April 2016

Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia ⬇️

scientific article published on June 15, 1998

BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation

scientific article

Brief report: Loss of p15Ink4b accelerates development of myeloid neoplasms in Nup98-HoxD13 transgenic mice.

scientific article

Causes of oncogenic chromosomal translocation

scientific article published on 28 October 2005

Chromatin remodeling complex NURF regulates thymocyte maturation

scientific article

Chromosomal aberrations induced by double strand DNA breaks

scientific article

Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects

scientific article

Chromosomal translocations involving the MLL gene: molecular mechanisms

scientific article

Clinical and Molecular Consequences of Fusion Genes in Myeloid Malignancies

scientific article published on 03 August 2020

Cloning and characterization of a murine SIL gene

scientific article

Cloning and characterization of the SIL promoter

scientific article (publication date: 27 January 2003)

Complex MLL rearrangement in a patient with T-cell acute lymphoblastic leukemia

scientific article published on 01 September 1995

Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.

scientific article published on April 2007

Cytogenetics and molecular genetics of acute lymphoblastic leukemia

scientific article published on 01 October 2009

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

scientific article published on July 1997

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

scientific article published on 27 July 2014

Depletion of Cytotoxic T-Cells Does Not Protect NUP98-HOXD13 Mice from Myelodysplastic Syndrome but Reveals a Modest Tumor Immunosurveillance Effect ⬇️

scientific article published on May 11, 2012

Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice

scientific article published on 01 January 2001

Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

scientific journal article

Disruption of T cell regulatory pathways is necessary for immunotherapeutic cure of T cell acute lymphoblastic leukemia in mice.

scientific article published on December 2005

Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia ⬇️

scientific article published on November 1, 1992

Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity

scientific article

Distinct mechanisms lead to HPRT gene mutations in leukemic cells

scientific article published on April 2004

Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

scientific article

Effect of FLT3 ligand on survival and disease phenotype in murine models harboring a FLT3 internal tandem duplication mutation

scientific article published on June 2013

Efficient repair of DNA double-strand breaks in malignant cells with structural instability

scientific article

Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma ⬇️

scientific article published on June 21, 2012

Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish

scientific article

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

scientific article published on 16 April 2019

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

scientific article published on 6 July 2017

Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice

scientific article

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.

scientific article published on 13 January 2016

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes

scientific article

Gene expression profiling of precursor T-cell lymphoblastic leukemia/lymphoma identifies oncogenic pathways that are potential therapeutic targets

scientific article

Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break

scientific article published on 22 February 2017

Genetic interaction between Kit and Scl.

scientific article published on 08 July 2013

Genome Organization Drives Chromosome Fragility

scientific article

Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer

scientific article

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

scientific article published on 23 August 2013

Gradient of E2A activity in B-cell development

scientific article

Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity

scientific article published on 31 August 2018

HoxA9 binds and represses the Cebpa +8 kb enhancer. ⬇️

scientific article published on 23 May 2019

Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy ⬇️

scientific article published on February 15, 2012

Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome.

scientific article published on 04 July 2008

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

scientific article published on 23 January 2003

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

scientific article

Insertion of MLL sequences into chromosome band 5q31 results in an MLL-AF5Q31 fusion and is a rare but recurrent abnormality associated with infant leukemia

scientific article published on 01 July 2003

Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia ⬇️

scientific article (publication date: March 1992)

Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia

scientific article published on 19 February 2013

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

scientific article published on 8 February 2012

Landscape of insertion polymorphisms in the human genome

scientific article published on 4 March 2015

Leukemic transformation

scientific article published on 8 January 2004

Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.

scientific article published on 19 June 2008

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

scientific article

Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13–driven mouse model ⬇️

scientific article published on August 27, 2012

Loss of toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS.

scientific article published on 22 January 2018

MAGOH interacts with a novel RNA-binding protein

scientific article

MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children's Oncology Group Study

scientific article

Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context

scientific article published on 01 October 2001

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

scientific article published on 03 July 2020

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

scientific article

Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL ⬇️

scientific article published on February 1, 1991

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

scientific article

Mouse models of myelodysplastic syndromes

scientific article

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia

scientific article published on 15 February 2018

Myeloablative hematopoietic stem cell transplantation improves survival but is not curative in a pre-clinical model of myelodysplastic syndrome.

scientific article published on 27 September 2017

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

scientific article published on 26 September 2011

NUP98 gene fusions in hematologic malignancies.

scientific article

NUP98-HOX translocations lead to myelodysplastic syndrome in mice and men

scientific article published on January 2008

NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia.

scientific article

NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.

scientific article

NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation

scientific article published on 20 April 2004

Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

scientific article

Notching up MYC gives a LIC.

scientific article published on July 2013

OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1

scientific article

Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome

scientific article published on 16 August 2013

Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations

scientific article published on 01 October 2000

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways

scientific article published on 08 September 2017

Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients ⬇️

scientific article published on April 1, 1998

Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome

scientific article

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.

scientific article

Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.

scientific article published on June 2007

SCL binds the human homologue of DRG in vivo

scientific article

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

scientific article published on 23 August 2018

Short-term storage of blood samples and DNA isolation in serum separator tubes for application in epidemiological studies and clinical research

scientific article published on 01 November 2000

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.

scientific article published in April 1996

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.

scientific article published on 14 February 2017

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia

scientific article

Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis

scientific journal article

Templated Sequence Insertion Polymorphisms in the Human Genome

scientific article

The Mammalian Homologue of Mago Nashi Encodes a Serum-Inducible Protein ⬇️

scientific article published on January 15, 1998

The SCL gene is formed from a transcriptionally complex locus

scientific article

The SCL gene product: a positive regulator of erythroid differentiation ⬇️

scientific article published on November 1, 1992

The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr ⬇️

scientific article published on January 18, 2011

The TLX1 oncogene drives aneuploidy in T cell transformation

scientific article

The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells.

scientific article published in January 2003

The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

scientific article published on 21 September 2013

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif

scientific article

The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?

scientific article

The mitotic checkpoint gene, SIL is regulated by E2F1.

scientific article published on October 2008

The role of CALM-AF10 gene fusion in acute leukemia

scientific article published on 20 December 2007

The role of NUP98 gene fusions in hematologic malignancy

scientific article

The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute myeloid leukemia in children: an evidence-based review

scientific article published on January 2007

The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene

scientific article

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment

scientific article

Therapy-related T cell lymphoblastic lymphoma with t(11;19)(q23;p13) and MLL gene rearrangement

scientific article published on 01 December 1999

Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL

scientific article published on 26 March 2015

Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice

scientific article published on 20 November 2019

Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell

scholarly article

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

scientific article

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

scientific article published on 03 October 2018

p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis

scientific article

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