Search filters

List of works by Stefan H I Kappe

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections ⬇️

scientific article published on September 18, 2010

A Plasmodium parasite with complete late liver stage arrest protects against pre-erythrocytic and erythrocytic stage infection in mice

scientific article published on 12 February 2018

A Plasmodium yoelii Mei2-Like RNA Binding Protein Is Essential for Completion of Liver Stage Schizogony

scientific article (publication date: May 2016)

A Plasmodium α/β-hydrolase modulates the development of invasive stages

scientific article (publication date: December 2015)

A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry

article

A clash to conquer: the malaria parasite liver infection

scientific article published on December 2006

A combined transcriptome and proteome survey of malaria parasite liver stages

scholarly article

A dispensable Plasmodium locus for stable transgene expression

scientific article

A genetically attenuated parasite vaccine does not require liver stage persistence to elicit sterile protective immunity against sporozoite-induced malaria in mice

scientific article published in April 2010

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

scientific article published on 19 March 2018

A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites

scientific article published in January 2004

A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion

scientific article published on 14 May 2014

A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway

scientific article (publication date: 8 November 2013)

A novel immune regulator links malaria and inflammatory bowel disease

scientific article

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.

scientific article

A rapid and scalable density gradient purification method for Plasmodium sporozoites

scientific article published on 17 December 2012

A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase

scientific article

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

scientific article published on 10 October 2013

A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii

scientific article published on 31 August 2011

A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle

scientific article published on 27 October 2012

Advances and challenges in malaria vaccine development.

scientific article

Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection

An efficient strategy for gene targeting and phenotypic assessment in the Plasmodium yoelii rodent malaria model

scientific article published on 15 December 2007

Apicomplexan gliding motility and host cell invasion: overhauling the motor model

scientific article

Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysis

scientific article published on July 2008

Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections.

scientific article published in June 2019

Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein

scientific article

CD40 is required for protective immunity against liver stage Plasmodium infection

scientific article

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect

scientific article

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

scientific article

Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects

scientific article published on January 2017

Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites

scientific article

Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

scientific article published in June 2016

Cyclic GMP balance is critical for malaria parasite transmission from the mosquito to the mammalian host

scientific article (publication date: 17 March 2015)

Depletion of the Plasmodium berghei thrombospondin-related sporozoite protein reveals a role in host cell entry by sporozoites

scientific article (publication date: June 2007)

Development of a quantitative flow cytometry-based assay to assess infection by Plasmodium falciparum sporozoites

scientific article published on 8 February 2012

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes

scientific article

Differential transcriptome profiling identifies Plasmodium genes encoding pre-erythrocytic stage-specific proteins

scientific article published in March 2004

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites

scientific article (publication date: August 2011)

Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host

scientific article published on 18 August 2008

Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development

scientific article (publication date: February 2014)

Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: clearance after immunization, susceptibility to primaquine, and contribution to blood-stage infection

scientific article

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

scientific article published on 8 September 2013

Flow Cytometry-Based Assessment of Antibody Function Against Malaria Pre-erythrocytic Infection

scientific article published on January 2015

Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells

scientific article published on 9 July 2007

Genetically attenuated malaria parasites as vaccines

scientific article published on 14 June 2017

Genetically attenuated parasite vaccines induce contact-dependent CD8+ T cell killing of Plasmodium yoelii liver stage-infected hepatocytes

scientific article published on 7 October 2009

Genetically engineered, attenuated whole-cell vaccine approaches for malaria

scientific article published on 29 January 2010

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

scientific article published on 5 December 2004

Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection

scientific article published in May 2008

Host ER stress during malaria parasite infection

scientific article published on 2 July 2015

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

scientific article

Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites

scientific article published on 4 February 2015

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

scientific article

Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity

scientific article published on 19 April 2018

Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice

scientific article published on 9 October 2017

Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein

scientific article (publication date: 2016)

Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies

scientific article published on 8 February 2018

Immunization of mice with live-attenuated late liver stage-arresting Plasmodium yoelii parasites generates protective antibody responses to preerythrocytic stages of malaria

scientific article

Immunization with genetically attenuated P. falciparum parasites induces long-lived antibodies that efficiently block hepatocyte invasion by sporozoites

scientific article

Immunology. Another shot at a malaria vaccine

scientific article published in October 2011

Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stage

scientific article published on 12 August 2002

Interferon-mediated innate immune responses against malaria parasite liver stages

scientific article published on 3 April 2014

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

scientific article (publication date: April 2016)

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites

scientific article

Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum

scientific article published on 25 October 2013

L-FABP is a critical host factor for successful malaria liver stage development.

scientific article published on 14 January 2007

Malaria Parasite Liver Infection and Exoerythrocytic Biology

scientific article

Malaria liver stage culture: in vitro veritas?

scientific article published in May 2006

Malaria parasite development in the mosquito and infection of the mammalian host

scientific article

Malaria parasite pre-erythrocytic infection: preparation meets opportunity

scientific article published on 09 January 2012

Malaria parasite pre-erythrocytic stage infection: gliding and hiding

scientific article published on 11 September 2008

Malaria parasites target the hepatocyte receptor EphA2 for successful host infection

scientific article (publication date: 27 November 2015)

Malaria vaccine development: persistent challenges

scientific article published on 21 April 2012

Malaria: progress, perils, and prospects for eradication

scientific article

Measurement of Antibody-Mediated Reduction of Plasmodium yoelii Liver Burden by Bioluminescent Imaging

scientific article published on January 2015

Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites

scientific article published on 14 May 2015

Microbiology. Malaria's stealth shuttle

scientific article published in September 2006

Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum

scientific article published on 09 December 2013

Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs

scientific article

Myosin A tail domain interacting protein (MTIP) localizes to the inner membrane complex of Plasmodium sporozoites

scientific article published in 2003

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

scientific article published on 28 November 2017

Neuroimmunological blood brain barrier opening in experimental cerebral malaria

scientific article

Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections

scientific article

P. falciparum enhances HIV replication in an experimental malaria challenge system

scientific article (publication date: 2012)

Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

scientific article published on 27 February 2013

PfCap380 as a marker for Plasmodium falciparum oocyst development in vivo and in vitro

article

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood

scholarly article published by Stephen L Hoffman in 2018

Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo.

scientific article

Plasmodium falciparum MAEBL is a unique member of the ebl family

scientific article (publication date: June 2002)

Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages

scientific article (publication date: May 2010)

Plasmodium falciparum genetic crosses in a humanized mouse model

scientific article

Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface

scientific article

Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection.

scientific article published in February 2010

Plasmodium sporozoite molecular cell biology

scientific article published in January 2004

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

scientific article published on 19 March 2015

Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal

scientific article published on 18 December 2017

Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development

scientific article published on 14 March 2013

Plasmodium yoelii macrophage migration inhibitory factor is necessary for efficient liver-stage development

scientific article published on 17 January 2012

Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection

scientific article

Preerythrocytic malaria vaccine development

scientific article published on October 2007

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

scientific article (publication date: 4 August 2009)

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

scientific article (publication date: 9 May 2016)

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

scientific article

Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells.

scientific article

Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii

scientific article

Quantitative isolation and in vivo imaging of malaria parasite liver stages

scientific article published on 12 July 2006

Real-time quantitative reverse transcription PCR for monitoring of blood-stage Plasmodium falciparum infections in malaria human challenge trials

scientific article published on March 2012

Redefining the role of de novo fatty acid synthesis in Plasmodium parasites.

scientific article published on 12 October 2009

Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature

scientific article published in November 2007

SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages.

scientific article published on 22 December 2010

SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility

scientific article

Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge

scientific article

Short-lived effector CD8 T cells induced by genetically attenuated malaria parasite vaccination express CD11c

scientific article published on 26 August 2013

Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice

scientific article published on 20 January 2010

Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites

scientific article

Suppression of host p53 is critical for Plasmodium liver-stage infection

scientific article published on 7 March 2013

Susceptibility to Plasmodium liver stage infection is altered by hepatocyte polyploidy

scientific article

Susceptibility to Plasmodium yoelii Preerythrocytic Infection in BALB/c Substrains Is Determined at the Point of Hepatocyte Invasion ⬇️

scientific article (publication date: 13 October 2014)

Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection

scientific article published on 05 May 2008

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity

scientific article published in November 2017

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity

scientific article published on 01 April 2018

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

scientific article

The Micronemal Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes

article

The Plasmodium sporozoite journey: a rite of passage

scientific article

The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species

scientific article published on 11 October 2011

The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast

scientific article

The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle

scientific article published on 26 November 2016

Total and putative surface proteomics of malaria parasite salivary gland sporozoites.

scientific article published on 16 January 2013

Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection

scientific article published on March 2017

Transformation of Sporozoites into Early Exoerythrocytic Malaria Parasites Does Not Require Host Cells ⬇️

scientific article published on April 21, 2003

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

scientific article

Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes

scientific article (publication date: May 2014)

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

scientific article published on 03 December 2008

Vaccination using radiation- or genetically attenuated live sporozoites

scientific article published in January 2013

Whole parasite vaccination approaches for prevention of malaria infection

scientific article published on 07 March 2012

Paulina is supported by:

About Paulina

Help