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List of works by François Vaillant

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

scientific article published on 05 December 2018

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1.

scientific article

A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

scientific article published on 05 May 2021

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

scientific article published on 2 August 2009

Abstract 1130: First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER+ breast cancer with KAT6A dysregulation

scientific article published in 2021

Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells.

scientific article published in February 2012

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

scientific article published in Nature Communications

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

scientific article

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

scientific article published in Nature Communications

Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain

scientific journal article

Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling.

scientific article published on 20 November 2017

Control of mammary stem cell function by steroid hormone signalling.

scientific article published on 11 April 2010

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary.

scientific article published on 18 July 2014

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

scientific article published on 03 April 2020

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

scientific article

Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection

scientific article published on 01 September 2002

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

scientific article published on 25 October 2018

Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.

scientific article published on 19 September 2011

Generation of a functional mammary gland from a single stem cell

scientific article (publication date: 5 January 2006)

Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2.

scientific article

Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive.

scientific article

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

scientific article published on 01 June 2019

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

scientific article published on 28 March 2019

Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

scientific article published on 25 May 2011

Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers

scientific article

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

scientific article published on 07 October 2019

Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

scientific article published in October 2008

Patient-derived xenograft (PDX) models in basic and translational breast cancer research.

scientific article published on 27 December 2016

Plasma membrane NADH-oxidoreductase in cells carrying mitochondrial DNA G11778A mutation and in cells devoid of mitochondrial DNA (rho0).

scientific article published in January 2004

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

scientific article published on 12 March 2021

Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations.

scientific article

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.

scientific article

Publisher Correction: Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

scientific article published on 24 April 2019

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.

scientific article published on 20 June 2016

RE: Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

scientific article published on 4 April 2017

ROAST: rotation gene set tests for complex microarray experiments

scientific article

Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo

scientific article published on 01 February 2006

Runx2 in normal tissues and cancer cells: A developing story.

scientific article published on 26 June 2010

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

scientific article published on 18 July 2011

Single cell transcriptome atlas of mouse mammary epithelial cells across development

scientific article published on 29 June 2021

Steroid hormone receptor status of mouse mammary stem cells

scientific article

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

scientific article published in August 2017

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

scientific article

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

scientific article published on 27 April 2020

The Runx genes as dominant oncogenes

scientific article

The emerging picture of the mouse mammary stem cell

scientific article published on June 2007

The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis

scientific article published on 01 October 2008

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

scientific article published on 27 April 2020

Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

scientific article

c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.

scientific article

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