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List of works by Aravinda M. de Silva

A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins

scientific article

A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface

scientific article

A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice

scientific article published on 8 January 2018

An Immunogenic and Protective Alphavirus Replicon Particle-Based Dengue Vaccine Overcomes Maternal Antibody Interference in Weanling Mice

scientific article (publication date: October 2007)

An alphavirus vector-based tetravalent dengue vaccine induces a rapid and protective immune response in macaques that differs qualitatively from immunity induced by live virus infection

scientific article published on 9 January 2013

Analysis of Individuals from a Dengue-Endemic Region Helps Define the Footprint and Repertoire of Antibodies Targeting Dengue Virus 3 Type-Specific Epitopes

scientific article published on 19 September 2017

Analyzing the Human Serum Antibody Responses to a Live Attenuated Tetravalent Dengue Vaccine Candidate

article

Antibodies targeting dengue virus envelope domain III are not required for serotype-specific protection or prevention of enhancement in vivo ⬇️

scientific article published on April 25, 2012

Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees

scientific article published on 01 October 2020

Arguments for live flavivirus vaccines

scientific article published on 01 August 2004

Beyond Neutralizing Antibody Levels: The Epitope Specificity of Antibodies Induced by National Institutes of Health Monovalent Dengue Virus Vaccines.

scientific article

Burden of dengue infection and disease in a pediatric cohort in urban Sri Lanka

scientific article

Characterization of Borrelia burgdorferi aggregates

scientific article

Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses

Clinical development and regulatory points for consideration for second-generation live attenuated dengue vaccines

scientific article published on 7 March 2018

Comparison of Plaque- and Flow Cytometry-Based Methods for Measuring Dengue Virus Neutralization

scientific article

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells

scientific article published on 11 April 2013

Correction: In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection

Corrigendum to ''Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model'' [EBioMedicine 41 (2019) 465-478]

scientific article published on 03 April 2020

Corrigendum to “Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes” [Virology 410 (2011) 240–247]

scholarly article by Zhihua Kou published in May 2011

Cutting Edge: Transcriptional Profiling Reveals Multifunctional and Cytotoxic Antiviral Responses of Zika Virus-Specific CD8 T Cells

article

DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

scientific article

Delineating the serotype-specific neutralizing antibody response to a live attenuated tetravalent dengue vaccine

scientific article published on 27 March 2018

Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site

scientific article

Dengue type 1 viruses circulating in humans are highly infectious and poorly neutralized by human antibodies

scientific article published on 05 December 2018

Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity

scientific article published on 02 January 2014

Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity

scientific article published on 20 July 2015

Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibody

scientific article (publication date: 15 September 2009)

Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope

scientific article published on 2 April 2018

Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera

scientific article

Determining dengue virus serostatus by indirect IgG ELISA compared with focus reduction neutralisation test in children in Cebu, Philippines: a prospective population-based study

scientific article published on 13 November 2020

Development and Characterization of a Reverse Genetic System for Studying Dengue Virus Serotype 3 Strain Variation and Neutralization ⬇️

scientific article published on February 28, 2012

Development of envelope protein antigens to serologically differentiate Zika from dengue virus infection

scientific article published on 20 December 2017

Dimerization of dengue virus E-subunits impacts antibody function and domain focus

scientific article published on 01 July 2020

Dissecting Antibodies Induced by a Chimeric Yellow Fever-Dengue, Live-Attenuated, Tetravalent Dengue Vaccine (CYD-TDV) in Naive and Dengue-Exposed Individuals.

scientific article published on 08 December 2016

Dissecting the human serum antibody response to secondary dengue virus infections

scientific article

Does host complement kill Borrelia burgdorferi within ticks?

scientific article

Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies

scientific article published on 28 May 2020

Emergence and global spread of a dengue serotype 3, subtype III virus

scientific article published on July 2003

Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever

scientific article published on June 2002

Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone

scientific article published on January 2017

Estimates of dengue force of infection in children in Colombo, Sri Lanka

scientific article

Evaluation of a new point-of-care test to determine prior dengue infection for potential use in pre-vaccination screening

scientific article published on 28 August 2020

Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1.

scientific article published on 9 March 2016

Genetic Variation between Dengue Virus Type 4 Strains Impacts Human Antibody Binding and Neutralization

scientific article published on 01 October 2018

Genetic analysis of Dengue 3 virus subtype III 5' and 3' non-coding regions

scientific article

Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle

scientific article

Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas

scientific article published on 13 October 2017

Host response: Cross-fit T cells battle Zika virus

scientific article

Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes

scientific article published on 4 December 2010

Human antibody response to Zika targets type-specific quaternary structure epitopes

scholarly article by Matthew H Collins et al published 18 April 2019 in JCI insight

Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes

scientific article

Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics

scientific article published on 22 March 2013

Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

scientific article

Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

article

In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers

scientific article

In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection

scientific article

Innovative and new approaches to laboratory diagnosis of Zika and dengue: a meeting report

scientific article published on 25 December 2017

Insights into HLA-restricted T cell responses in a novel mouse model of dengue virus infection point toward new implications for vaccine design

scientific article

Interactions of OspA monoclonal antibody C3.78 with Borrelia burgdorferi within ticks

scientific article

Isolation of dengue virus-specific memory B cells with live virus antigen from human subjects following natural infection reveals the presence of diverse novel functional groups of antibody clones

scientific article

Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

scientific article (publication date: May 2017)

Longitudinal Analysis of Antibody Cross-Neutralization Following Zika and Dengue Virus Infection in Asia and the Americas

scientific article

Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model

article

Low copy numbers of DC-SIGN in cell membrane microdomains: implications for structure and function

scientific article

Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to DENV4 Infection and Vaccination

scientific article (publication date: 28 December 2016)

Measuring antibody neutralization of dengue virus (DENV) using a flow cytometry-based technique

scientific article published on January 2014

N-linked glycans on dengue viruses grown in mammalian and insect cells

scientific article

Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype

scholarly article by Stefan W Metz et al published September 2018 in PLoS Neglected Tropical Diseases

Natural Strain Variation and Antibody Neutralization of Dengue Serotype 3 Viruses

scientific article (publication date: 19 March 2010)

New dengue virus type 1 genotype in Colombo, Sri Lanka

scientific article published in November 2011

Oligomeric state of the ZIKV E protein defines protective immune responses

scientific article published on 10 October 2019

Optimization of Surface Display of DENV2 E Protein on a Nanoparticle to Induce Virus Specific Neutralizing Antibody Responses

article

Performance of Dried Blood Spots Compared with Serum Samples for Measuring Dengue Seroprevalence in a Cohort of Children in Cebu, Philippines

scientific article published on 02 November 2020

Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection

scientific article published on 14 December 2011

Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins

scientific article

Pichia pastoris-expressed dengue 2 envelope forms virus-like particles without pre-membrane protein and induces high titer neutralizing antibodies

scientific article

Pichia pastoris-expressed dengue 3 envelope-based virus-like particles elicit predominantly domain III-focused high titer neutralizing antibodies.

scientific article published on 23 September 2015

Plasmid requirements for infection of ticks by Borrelia burgdorferi

scientific article published in January 2005

Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses

scientific article

Preexisting neutralizing antibody responses distinguish clinically inapparent and apparent dengue virus infections in a Sri Lankan pediatric cohort

scientific article

Prior Dengue virus exposure shapes T cell immunity to Zika virus in humans

scientific article published on 4 October 2017

Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus

scientific article

Rapid, directed transport of DC-SIGN clusters in the plasma membrane.

scientific article published on 8 November 2017

Reciprocal expression of ospA and ospC in single cells of Borrelia burgdorferi

scientific article published on 21 March 2008

Recombinant dengue type 2 viruses with altered e protein domain III epitopes are efficiently neutralized by human immune sera

scientific article published on 25 January 2012

Role of Borrelia burgdorferi linear plasmid 25 in infection of Ixodes scapularis ticks

scientific article

Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies

scientific article published on 17 September 2019

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

scientific article

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

scientific article published on 27 May 2020

Safety of Dengue Vaccine?

scientific article published in 2022

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

scientific article

Seroepidemiology of Dengue, Zika, and Yellow Fever Viruses among Children in the Democratic Republic of the Congo

scientific article published on 05 July 2018

Serologic surveillance of maternal Zika infection in a prospective cohort in Leon, Nicaragua during the peak of the Zika epidemic

scientific article published on 03 April 2020

Severe Dengue Epidemic, Sri Lanka, 2017

scientific article published on 01 April 2020

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model

scientific article published on 24 August 2015

Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection

scientific article published in June 2015

Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus

scientific article published in 2023

Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

scientific article published on 20 May 2020

The Emerging Zika Virus Epidemic in the Americas: Research Priorities

scientific article

The Human Antibody Response to Dengue Virus Infection ⬇️

scientific article published on November 25, 2011

The Molecular Specificity of the Human Antibody Response to Dengue Virus Infections

scientific article published on 01 January 2018

The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies

scientific article published on 10 May 2020

The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity

scientific article published on September 2010

The mechanism of differential neutralization of dengue serotype 3 strains by monoclonal antibody 8A1.

scientific article published on 28 February 2013

The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein

scientific article

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

scientific article published on 01 June 2020

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

scientific article published on 20 September 2019

Tracking the polyclonal neutralizing antibody response to a dengue virus serotype 1 type-specific epitope across two populations in Asia and the Americas

scientific article published on 07 November 2019

Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype 4.

scientific article published on 7 December 2017

Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua

scientific article (publication date: October 2016)

Unsuspected dengue and acute febrile illness in rural and semi-urban southern Sri Lanka

scientific article published in February 2012

Viral Entry and NS1 as Potential Antiviral Drug Targets.

scientific article published in January 2018

Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials

scientific article published on 17 July 2017

Zika virus infection enhances future risk of severe dengue disease

scientific article

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

scientific article

ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas

scientific article published on 01 January 2019

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