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List of works by Robert H. Silverman

2-5A ligands--a new concept for the treatment of prostate cancer

scientific article published in January 2007

3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L.

scientific article

A convenient and sensitive fluorescence resonance energy transfer assay for RNase L and 2',5' oligoadenylates

scientific article published on January 2005

A natural human retrovirus efficiently complements vectors based on murine leukemia virus

scientific article

A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

scientific article published on 13 April 2018

A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency

scientific article published on 21 September 2020

A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.

scientific article published on 7 March 2007

A putative loop E motif and an H-H kissing loop interaction are conserved and functional features in a group C enterovirus RNA that inhibits ribonuclease L

scientific article published on 9 October 2008

A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.

scientific article

A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L

scientific article (publication date: June 2008)

Absence of PKR attenuates the anti-HSV-1 activity of an adenoviral vector expressing murine IFN-beta

scientific article published on August 2002

Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1

scientific article (publication date: 2012)

Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon

scientific article published on 6 January 2016

Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.

scientific article published on 12 November 2019

Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

scientific article published on 8 February 2016

Activation of the interferon system by short-interfering RNAs

scientific article (publication date: September 2003)

Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.

scientific article

Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

scientific article

An alternative spliced RNASEL variant in peripheral blood leukocytes

scientific article published on 01 November 2006

An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase

scientific article published on 21 October 2003

An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors

scholarly article

Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus

scientific article published on 21 September 2011

Androgen stimulates transcription and replication of xenotropic murine leukemia virus-related virus

scientific article

Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology

scientific article published on June 2012

Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.

scientific article

Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.

scientific article published on 22 May 2013

Cell-type-specific effects of RNase L on viral induction of beta interferon

scientific article published on 25 February 2014

Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies

scientific article

Correction: Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant ⬇️

scientific article published on September 18, 2012

Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection

scientific article

Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation

scientific article

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux

scientific article

Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat

scientific article published on 01 December 2006

Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome

scientific article published in Science in 2009 and retracted in 2011

Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection.

scientific article published in February 2005

Differential effect of murine alpha/beta interferon transgenes on antagonization of herpes simplex virus type 1 replication

scientific article published on July 2002

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

scientific article

Distinctive roles for 2',5'-oligoadenylate synthetases and double-stranded RNA-dependent protein kinase R in the in vivo antiviral effect of an adenoviral vector expressing murine IFN-beta.

scientific article

Down-regulation of p53 by double-stranded RNA modulates the antiviral response

scientific article published on September 2005

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

scientific article

Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates ⬇️

scientific article published on October 15, 2003

Endowing RNase H-inactive antisense with catalytic activity: 2-5A-morphants

scientific article

Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L

scientific article

Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer

scientific article

Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus

scientific article

Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains.

scientific article

Genetic susceptibility and oxidative stress in prostate cancer: integrated model with implications for prevention

scientific article published on December 2006

HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand.

scientific article

Hepatitis C virus RNA: Dinucleotide frequencies and cleavage by RNase L

scientific article

Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production

scientific article published on January 2009

Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity ⬇️

scientific article published on July 22, 2013

Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models

scientific article published on January 2006

In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins ⬇️

scientific article published on October 6, 2011

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer

scientific article

Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV

scientific article

Inflammation, infection, and prostate cancer

scientific article published on May 2008

Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity ⬇️

scientific article published on June 2, 2011

Inhibition of human parainfluenza virus type 3 infection by novel small molecules

scientific article

Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer

scientific article

Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.

scientific article

Interferon-beta suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway

scientific article

Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice.

scientific article

Interferons at age 50: past, current and future impact on biomedicine

scientific article

Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation.

scientific article published on February 2005

Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.

scientific article published on 21 December 2016

Mapping of the human RNASEL promoter and expression in cancer and normal cells

scientific article published on October 2005

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.

scientific article published on 29 March 2016

Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene.

scientific article

New Insights into the Role of RNase L in Innate Immunity ⬇️

scientific article published on December 29, 2010

No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients

scientific article (publication date: 2012)

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L ⬇️

scientific article published on August 3, 2011

OAS and PKR are not required for the antiviral effect of Ad:IFN-gamma against acute HSV-1 in primary trigeminal ganglia cultures.

scientific article

OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug

scientific article

PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

scientific article (publication date: July 2006)

Partial retraction. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome

scientific article published in October 2011

Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants

scientific article

Phospholipid scramblase 1 potentiates the antiviral activity of interferon

scientific article

Proteasome-Mediated Degradation of RNase L in Response to Phorbol-12-Myristate-13-Acetate (PMA) Treatment of Mouse L929 Cells ⬇️

scientific article published on October 1, 2003

Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.

scientific article published on 14 July 2008

RETRACTED: Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant

retracted scientific article

RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2.

scientific article

RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases

scientific article published on 4 November 2002

RNase L Triggers Autophagy in Response to Viral Infections ⬇️

scientific article published on August 8, 2012

RNase L activates the NLRP3 inflammasome during viral infections

scientific article

RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection.

scientific article published in February 2005

RNase L is a negative regulator of cell migration

scientific article published on 27 October 2015

RNase L mediated protection from virus induced demyelination

scientific article

RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.

scientific article published on 11 February 2003

RNase L plays a role in the antiviral response to West Nile virus

scientific article

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.

scientific article

RNase L restricts the mobility of engineered retrotransposons in cultured human cells

scientific article (publication date: April 2014)

RNase L targets distinct sites in influenza A virus RNAs.

scientific article

RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer

scientific article published on May 2013

Reverse signaling through membrane-bound interleukin-15.

scientific article published on 28 July 2004

Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.

scientific article

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

scientific article

Role of Ribonuclease L in Viral Pathogen-Associated Molecular Pattern/Influenza Virus and Cigarette Smoke–Induced Inflammation and Remodeling ⬇️

scientific article published on 02 August 2013

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

scientific article published on 25 September 2020

Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells

scientific article published on December 2006

Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites

scientific article

Sexual Transmission of XMRV: A Potential Infection Route ⬇️

scientific article published on July 24, 2011

Small self-RNA generated by RNase L amplifies antiviral innate immunity

scientific article published on 25 July 2007

Small-molecule activators of RNase L with broad-spectrum antiviral activity

scientific article

Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.

scientific article published on July 2015

Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death

scientific article published on 23 April 2020

Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death

scientific article published on 01 October 2020

Suppression of Antiviral Innate Immunity by Sunitinib Enhances Oncolytic Virotherapy ⬇️

scientific article published on 04 June 2013

Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1

scientific article (publication date: 15 January 2002)

Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense

scientific article published on January 2002

Targeting RNA for Degradation with a (2', 5')-Oligoadenylate Antisense Chimera

The Use of Triisopropylsilyl-oxymethyl (TOM) in the Synthesis of Anti-telomerase 2-5A Antisense Compound RBI 011 ⬇️

scientific article published on May 1, 2003

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

scientific article published on June 2010

The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection.

scientific article published in August 2006

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

scientific article

The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture

scientific article published in August 2003

Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector.

scientific article published in February 2007

Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A

scientific article

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

scientific article

XMRV Discovery and Prostate Cancer-Related Research ⬇️

scientific article published on June 21, 2011

XMRV replicates preferentially in mucosal sites in vivo: Relevance to XMRV transmission?

scientific article

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